Bacterial Efflux Pump Inhibitors Reduce Antibiotic Resistance [PDF]
PharmaceuticsBacterial resistance is a growing problem worldwide, and the number of deaths due to drug resistance is increasing every year. We must pay great attention to bacterial resistance.
Lan Zhang +6 more
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Terpenes as bacterial efflux pump inhibitors: A systematic review [PDF]
Frontiers in Pharmacology, 2022 Managing antibiotic resistance is a significant challenge in modern pharmacotherapy. While molecular analyses have identified efflux pump expression as an essential mechanism underlying multidrug resistance, the targeted drug development has occurred ...
Kaio Jefté Santos De Oliveira Dias +10 more
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Multidrug Efflux Pumps in Bacteria and Efflux Pump Inhibitors
Postępy Mikrobiologii, 2022 Antimicrobial resistance is becoming a paramount health concern nowadays. The increasing drug resistance in microbes is due to improper medications or over usage of drugs. Bacteria develop many mechanisms to extrude the antibiotics entering the cell. The
Sreekantan Abhirami P. +3 more
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Types and Mechanisms of Efflux Pump Systems and the Potential of Efflux Pump Inhibitors in the Restoration of Antimicrobial Susceptibility, with a Special Reference to Acinetobacter baumannii [PDF]
PathogensBacteria express a plethora of efflux pumps that can transport structurally varied molecules, including antimicrobial agents and antibiotics, out of cells.
Kira M. Zack +2 more
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Role of bacterial efflux pumps in antibiotic resistance, virulence, and strategies to discover novel efflux pump inhibitors. [PDF]
Microbiology (Reading), 2023 The problem of antibiotic resistance among pathogenic bacteria has reached a crisis level. The treatment options against infections caused by multiple drug-resistant bacteria are shrinking gradually. The current pace of the discovery of new antibacterial
Gaurav A +4 more
europepmc +4 more sources
Effect of α-Bisabolol and Its β-Cyclodextrin Complex as TetK and NorA Efflux Pump Inhibitors in Staphylococcus aureus Strains [PDF]
Antibiotics, 2020 Efflux pumps are proteins present in the plasma membrane of bacteria, which transport antibiotics and other compounds into the extracellular medium, conferring resistance. The discovery of natural efflux pump inhibitors is a promising alternative. α-
Rafael Pereira da Cruz +14 more
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Advances in the Discovery of Efflux Pump Inhibitors as Novel Potentiators to Control Antimicrobial-Resistant Pathogens. [PDF]
Antibiotics (Basel), 2023 The excessive use of antibiotics has led to the emergence of multidrug-resistant (MDR) pathogens in clinical settings and food-producing animals, posing significant challenges to clinical management and food control.
Zhang S, Wang J, Ahn J.
europepmc +2 more sources
Update on the Discovery of Efflux Pump Inhibitors against Critical Priority Gram-Negative Bacteria. [PDF]
Antibiotics (Basel), 2023 Antimicrobial resistance (AMR) has become a major problem in public health leading to an estimated 4.95 million deaths in 2019. The selective pressure caused by the massive and repeated use of antibiotics has led to bacterial strains that are partially ...
Compagne N +5 more
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Efflux Pump Inhibitors in Controlling Antibiotic Resistance: Outlook under a Heavy Metal Contamination Context. [PDF]
Molecules, 2023 Multi-drug resistance to antibiotics represents a growing challenge in treating infectious diseases. Outside the hospital, bacteria with the multi-drug resistance (MDR) phenotype have an increased prevalence in anthropized environments, thus implying ...
Nguyen THT +10 more
europepmc +2 more sources
Evaluation of ellagic acid and gallic acid as efflux pump inhibitors in strains of Staphylococcus aureus. [PDF]
Biol Open, 2022 The Gram-positive bacterium Staphylococcus aureus is responsible for a number of infections and has been described to exhibit resistance to antibacterial drugs through different resistance mechanisms.
Macêdo NS +9 more
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