Results 101 to 110 of about 167,075 (204)
Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer
Advanced Science, EarlyView.In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen +10 more
wiley +1 more source
A novel inhibitor of multidrug efflux pumps in Staphylococcus aureus
, 2003 GG918, a synthetic inhibitor of P-glycoprotein-mediated mammalian tumour multidrug resistance, was found to be equipotent to reserpine in enhancing the in vitro activity of norfloxacin and ciprofloxacin against strains of Staphylococcus aureus expressing
Kaatz, Glenn W. +2 more
core +1 more source
One‐Step Immobilized Phage Depolymerase Coatings for Catheter‐Related Bloodstream Infections
Advanced Science, EarlyView.Catheter‐related bloodstream infections (CRBSI) caused by drug‐resistant Gram‐negative bacteria remain a major clinical challenge. Here, a polydopamine‐assisted depolymerase coating degrades bacterial capsules and restores serum‐mediated killing, effectively suppressing biofilms and reducing bacterial burden in vitro, ex vivo, and in vivo, presenting a
Lingkai Dong +11 more
wiley +1 more source
Iranian Journal of MicrobiologyBackground and Objectives: Pseudomonas aeruginosa (P. aeruginosa), a multidrug-resistant bacterium, represents a considerable risk in healthcare environments owing to its capacity to induce various infections. The resistance of P.
Fahad Ullah +9 more
doaj +1 more source
Functional analysis and NMR studies of multi-drug efflux pumps [PDF]
Efflux pumps play an important role in bacterial multi-drug resistance by actively expelling antibiotics and toxic compounds from the cell. We describe an integrated workflow for the characterisation of inner membrane efflux pumps, consisting of an in ...
Bonev, Boyan B. +5 more
core +1 more source
Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma
Advanced Science, EarlyView.This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert +8 more
wiley +1 more source
Efflux Pumps in Bacterial Antibiotic Resistance: Mechanisms, Clinical Implications, and Future Directions [PDF]
Due to the discovery of new resistance mechanisms and the decline in effective and high-quality treatments for common pathogenic illnesses, the increased spread of antibiotic resistance across many infectious pathogens has become an increasingly pressing
Mohsin, Sarah Mohammed +2 more
core +1 more source
, 2020 Susceptibility of reference bacterial strains and mutant strains with impaired efflux pumps to ciprofloxacin and NBTI compounds.
Carla Vignaroli (407543) +12 more
core +1 more source
Advanced Science, EarlyView.Heteroatom precursor engineering serves as a molecular‐level strategy to tailor hydrazide monomer reactivity and diffusion kinetics, enabling controlled assembly of highly crystalline COF membranes with ultramicroporous channels. The nitrogen‐enriched nanochannels deliver high water/ion selectivity via simultaneous water transport acceleration and ion ...
Guishan Hu +8 more
wiley +1 more source
Substrate Specificities and Efflux Efficiencies of RND Efflux Pumps of Acinetobacter baumannii
, 2018 Antibiotic-resistant Acinetobacter baumannii causes infections that are extremely difficult to treat. A significant role in these resistance profiles is attributed to multidrug efflux pumps, especially those belonging to the ...
Jon W. Weeks +5 more
core +1 more source