In-hospital safety in field conditions of nifurtimox eflornithine combination therapy (NECT) for T. b. gambiense sleeping sickness. [PDF]
PLoS Neglected Tropical Diseases, 2012 BackgroundTrypanosoma brucei (T.b.) gambiense Human African trypanosomiasis (HAT; sleeping sickness) is a fatal disease. Until 2009, available treatments for 2(nd) stage HAT were complicated to use, expensive (eflornithine monotherapy), or toxic, and ...
Caecilia Schmid +14 more
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Identification of transport systems involved in eflornithine delivery across the blood-brain barrier [PDF]
Frontiers in Drug Delivery, 2023 Human African Trypanosomiasis (HAT) is a neglected parasitic disease that continues to persist in sub-Saharan Africa. It is fatal if untreated. The first stage of the disease is associated with the presence of the parasite in the periphery and the second
Christopher P. Watson +2 more
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Enantiospecific antitrypanosomal in vitro activity of eflornithine.
PLoS Neglected Tropical Diseases, 2021 The polyamine synthesis inhibitor eflornithine is a recommended treatment for the neglected tropical disease Gambian human African trypanosomiasis in late stage.
Mikael Boberg +5 more
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The impact of thermophysical properties on eflornithine drug solute in acetone and ethyl acetate solvent interactions at varying concentrations and temperatures [PDF]
BMC ChemistryThe study was conducted on the impact of thermophysical properties on eflornithine drug solute–solvent interactions in aqueous ethyl acetate and acetone at different concentrations and temperatures.
Dereje Fedasa Tegegn, Shuma Fayera Wirtu
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Eflornithine Hydrochloride-Loaded Electrospun Nanofibers as a Potential Face Mask for Hirsutism Application [PDF]
Pharmaceutics, 2023 Hirsutism is a distressing condition that can affect women’s self-esteem due to the excessive amount of hair growth in different body parts, including the face. A temporary managing option is to develop a self-care routine to remove unwanted hair through
Shuruq S. Almuwallad +8 more
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Evolution, composition and functions of cullin E3 ubiquitin ligases in trypanosomes [PDF]
Scientific ReportsPost-translational modifications (PTMs) modulate protein functions, with ubiquitylation a pre-eminent example, and playing major roles in protein turnover.
Ricardo Canavate del Pino +3 more
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Conformational analysis of difluoromethylornithine: factors influencing its gas-phase and bioactive conformations [PDF]
Beilstein Journal of Organic ChemistryDifluoromethylornithine (DFMO, eflornithine) is a fluorinated analogue of ornithine that serves both as an inhibitor of ornithine decarboxylase and as a therapeutic agent against African trypanosomiasis.
Matheus P. Freitas
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Insights into antitrypanosomal drug mode-of-action from cytology-based profiling. [PDF]
PLoS Neglected Tropical Diseases, 2018 Chemotherapy continues to have a major impact on reducing the burden of disease caused by trypanosomatids. Unfortunately though, the mode-of-action (MoA) of antitrypanosomal drugs typically remains unclear or only partially characterised.
James A Thomas +7 more
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Frontiers in Chemistry, 2021 Targeting the polyamine biosynthetic pathway by inhibiting ornithine decarboxylase (ODC) is a powerful approach in the fight against diverse viruses, including SARS-CoV-2.
Joanna Bojarska +8 more
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Royal Society Open Science, 2021 Eflornithine (EFN) is an anti-Trypanosoma brucei agent for the medication of sleeping sickness and widely distributed for the treatment of hirsutism (unwanted facial hair in women).
Albandary Almahri +1 more
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