In-hospital safety in field conditions of nifurtimox eflornithine combination therapy (NECT) for T. b. gambiense sleeping sickness. [PDF]
PLoS Neglected Tropical Diseases, 2012 BackgroundTrypanosoma brucei (T.b.) gambiense Human African trypanosomiasis (HAT; sleeping sickness) is a fatal disease. Until 2009, available treatments for 2(nd) stage HAT were complicated to use, expensive (eflornithine monotherapy), or toxic, and ...
Caecilia Schmid +14 more
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Identification of transport systems involved in eflornithine delivery across the blood-brain barrier [PDF]
Frontiers in Drug Delivery, 2023 Human African Trypanosomiasis (HAT) is a neglected parasitic disease that continues to persist in sub-Saharan Africa. It is fatal if untreated. The first stage of the disease is associated with the presence of the parasite in the periphery and the second
Christopher P. Watson +2 more
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Melarsoprol versus eflornithine for treating late-stage Gambian trypanosomiasis in the Republic of the Congo [PDF]
Bulletin of the World Health Organization, 2006 OBJECTIVE: To compare the effectiveness of melarsoprol and eflornithine in treating late-stage Gambian trypanosomiasis in the Republic of the Congo. METHODS: We analysed the outcomes of death during treatment and relapse within 1 year of discharge for ...
Manica Balasegaram +5 more
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Enantiospecific antitrypanosomal in vitro activity of eflornithine.
PLoS Neglected Tropical Diseases, 2021 The polyamine synthesis inhibitor eflornithine is a recommended treatment for the neglected tropical disease Gambian human African trypanosomiasis in late stage.
Mikael Boberg +5 more
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The impact of thermophysical properties on eflornithine drug solute in acetone and ethyl acetate solvent interactions at varying concentrations and temperatures [PDF]
BMC ChemistryThe study was conducted on the impact of thermophysical properties on eflornithine drug solute–solvent interactions in aqueous ethyl acetate and acetone at different concentrations and temperatures.
Dereje Fedasa Tegegn, Shuma Fayera Wirtu
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Genotypic status of the TbAT1/P2 adenosine transporter of Trypanosoma brucei gambiense isolates from Northwestern Uganda following melarsoprol withdrawal. [PDF]
PLoS Neglected Tropical Diseases, 2009 BackgroundThe development of arsenical and diamidine resistance in Trypanosoma brucei is associated with loss of drug uptake by the P2 purine transporter as a result of alterations in the corresponding T.
Anne J N Kazibwe +5 more
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Systematic Review and Meta-Analysis on Human African Trypanocide Resistance [PDF]
Pathogens, 2022 Background Human African trypanocide resistance (HATr) is a challenge for the eradication of Human African Trypansomiaisis (HAT) following the widespread emergence of increased monotherapy drug treatment failures against Trypanosoma brucei gambiense and ...
Keneth Iceland Kasozi +2 more
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Eflornithine Hydrochloride-Loaded Electrospun Nanofibers as a Potential Face Mask for Hirsutism Application [PDF]
Pharmaceutics, 2023 Hirsutism is a distressing condition that can affect women’s self-esteem due to the excessive amount of hair growth in different body parts, including the face. A temporary managing option is to develop a self-care routine to remove unwanted hair through
Shuruq S. Almuwallad +8 more
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Evolution, composition and functions of cullin E3 ubiquitin ligases in trypanosomes [PDF]
Scientific ReportsPost-translational modifications (PTMs) modulate protein functions, with ubiquitylation a pre-eminent example, and playing major roles in protein turnover.
Ricardo Canavate del Pino +3 more
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Effects of Synthetic Ligustrazine-Based Chalcone Derivatives on Trypanosoma brucei brucei and Leishmania spp. Promastigotes [PDF]
Molecules, 2023 Current medication therapy for leishmaniasis and trypanosomiasis remains a major challenge due to its limited efficacy, significant adverse effects, and inaccessibility.
Abdulsalam A. M. Alkhaldi
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