Eflornithine for treatment of high-risk neuroblastoma. [PDF]
Trends Pharmacol SciJiang J, Yu Y.
europepmc +3 more sources
Eflornithine is a cost-effective alternative to melarsoprol for the treatment of second-stage human West African trypanosomiasis in Caxito, Angola. [PDF]
, 2008 OBJECTIVE: To compare the cost-effectiveness of eflornithine and melarsoprol in the treatment of human African trypanosomiasis. METHOD: We used data from a Médecins Sans Frontières treatment project in Caxito, Angola to do a formal cost-effectiveness ...
Adam +23 more
core +2 more sources
Human African trypanosomiasis : current status and eradication efforts [PDF]
, 2020 Epidemics of human African trypanosomiasis (HAT) in the 20th century led to millions of deaths. However, since the start of the twenty-first century, there is been a continued decline in the number of reported cases, due to increased investment and ...
Davis, Christopher +2 more
core +1 more source
Mortality trends and risk factors in advanced stage-2 Human African Trypanosomiasis: A critical appraisal of 23 years of experience in the Democratic Republic of Congo. [PDF]
PLoS Neglected Tropical Diseases, 2018 We conducted a retrospective study on mortality trends and risk factors in 781 naïve cases of advanced stage-2 sleeping sickness admitted between 1989 and 2012 at the National Reference Center for Human African Trypanosomiasis (HAT), Department of ...
Léon Mbiyangandu Kazumba +3 more
doaj +1 more source
A molecular mechanism for eflornithine resistance in African trypanosomes.
PLoS Pathogens, 2010 Human African trypanosomiasis, endemic to sub-Saharan Africa, is invariably fatal if untreated. Its causative agent is the protozoan parasite Trypanosoma brucei.
Isabel M Vincent +7 more
doaj +1 more source
Metabolite-dependent regulation of gene expression in trypanosoma brucei [PDF]
, 2013 Mechanisms regulating gene expression in trypanosomatid protozoa differ significantly from those in other eukaryotes. Transcription of the genome appears to be more or less constitutive with the polyadenylation and trans-splicing of large polycistronic ...
Archer +34 more
core +1 more source
CNS Oncology, 2018 This review covers the literature between 1989 and 2007 on studies relevant to the neuro-oncology usage of eflornithine (α-difluoromethylornithine), an oral agent that irreversibly inhibits the enzyme ornithine decarboxylase.
Victor A Levin +2 more
doaj +1 more source
pharma-kritik, 2009 Ein Ornithindekarboxylasehemmer, der in Form einer Crème bei Gesichtshirsutismus lokal appliziert werden kann. Bei etwa einem Drittel der behandelten Frauen lässt sich ein guter Erfolg erreichen, doch muss die Behandlung ständig weitergeführt werden.
openaire +1 more source
Effectiveness of melarsoprol and eflornithine as first-line regimens for gambiense sleeping sickness in nine Médecins Sans Frontières programmes. [PDF]
, 2008 This paper describes the effectiveness of first-line regimens for stage 2 human African trypanosomiasis (HAT) due to Trypanosoma brucei gambiense infection in nine Médecins Sans Frontières HAT treatment programmes in Angola, Republic of Congo, Sudan and ...
Balasegaram, M +5 more
core +1 more source
Parasites & Vectors, 2018 Background While the combination of nifurtimox and eflornithine (NECT) is currently recommended for the treatment of the late stage human African trypansomiasis (HAT), single-agent eflornithine was still the treatment of choice when this trial commenced.
Freddie Kansiime +9 more
doaj +1 more source