Results 61 to 70 of about 3,601 (193)

Comparison of the Pharmacokinetics of Eflornithine after Application of Eflornithine Cream and “Eflornithine: Armenicum” Composition in Rates

, 2023
This chapter reports the study results to determine percutaneous absorption and pharmacokinetics of eflornithine following topical treatment with eflornithine hydrochloride 13.9% cream and “eflornithine–armenicum” composition in rats. The model of aerobic wounds was developed. Eflornithine hydrochloride cream (dose of 460 mg/kg) was applied in group I,
Hovhannes, Ghazaryan,, Areg, Hovhannisyan,   +1 more
openaire   +2 more sources

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Safety and efficacy of hydroxyurea and eflornithine against most blood parasites Babesia and Theileria.

PLoS ONE, 2020
BACKGROUND:The plenteous resistance to and undesirable consequences of the existing antipiroplasmic therapies have emphasized the urgent need for new chemotherapeutics and drug targets for both prophylaxis and chemotherapy.
Gaber El-Saber Batiha, Amany Magdy Beshbishy, Oluyomi Stephen Adeyemi, Eman Nadwa, Eman Rashwan, Naoaki Yokoyama, Ikuo Igarashi   +6 more
doaj   +1 more source

Single‐Cell Atlas of Aging Human Skin Reveals FOSB‐Related Transcriptional Programs and Druggable Targets

Journal of Cosmetic Dermatology, Volume 24, Issue 12, December 2025.
ABSTRACT Background While human skin aging involves complex transcriptional alterations, the cell‐type‐specific regulatory mechanisms and therapeutic targets remain incompletely defined. The study aims to investigate aging‐associated transcriptional programs and drug‐responsive signatures at single‐cell resolution.
Youcheng Zhang, Yimin Wang, Dongze Lyu, Yinv Gong, Renpeng Zhou   +4 more
wiley   +1 more source

Effectiveness of melarsoprol and eflornithine as first-line regimens for gambiense sleeping sickness in nine Médecins Sans Frontières programmes [PDF]

, 2017
This paper describes the effectiveness of first-line regimens for stage 2 human African trypanosomiasis (HAT) due to Trypanosoma brucei gambiense infection in nine Médecins Sans Frontières HAT treatment programmes in Angola, Republic of Congo, Sudan and ...
Balasegaram, Manica, Chappuis, François, Checchi, Francesco, Priotto, Gerardo, Raguenaud, Marie-Eve, Young, Heather   +5 more
core  

The challenging problem of disease staging in human African trypanosomiasis (sleeping sickness): a new approach to a circular question [PDF]

, 2017
Human African trypanosomiasis (HAT), also known as sleeping sickness, puts millions of people at risk in sub-Saharan Africa and is a neglected parasitic disease that is almost always fatal if untreated or inadequately treated. HAT manifests itself in two
Gettinby, George, Kennedy, Peter G.E., Njamnshi, Alfred K.   +2 more
core   +1 more source

Melarsoprol versus eflornithine for treating late-stage Gambian trypanosomiasis in the Republic of the Congo

Bulletin of the World Health Organization, 2006
OBJECTIVE: To compare the effectiveness of melarsoprol and eflornithine in treating late-stage Gambian trypanosomiasis in the Republic of the Congo. METHODS: We analysed the outcomes of death during treatment and relapse within 1 year of discharge for ...
Manica Balasegaram, Steve Harris, Francesco Checchi, Sara Ghorashian, Catherine Hamel, Unni Karunakara   +5 more
doaj  

Eflornithine for chemoprevention in the high-risk population of colorectal cancer: a systematic review and meta-analysis with trial sequential analysis

Frontiers in Oncology, 2023
ObjectivesTo evaluate the efficacy of Difluoromethylornithine (DFMO) chemoprevention in the high-risk population for colorectal cancer (CRC).MethodsMeta-analysis was conducted to assess the caliber of the included literature by searching five databases ...
Lifeng Yang, Yan Wang, Shasha Hu, Xiaoyan Wang   +3 more
doaj   +1 more source

Evaluation of pyrrolidine and pyrazolone derivatives as inhibitors of trypanosomal phosphodiesterase B1 (TbrPDEB1) [PDF]

, 2015
Author Posting. © The Author(s), 2015. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution.
Amata, Emanuele, Bland, Nicholas D., Campbell, Robert K., Pollastri, Michael P.   +3 more
core   +1 more source

Integrating Metabolic Modulation and Nanomedicine for Cancer Immunotherapy

Advanced Science, Volume 12, Issue 40, October 27, 2025.
Metabolic rewiring in cancer is mapped across glucose, amino acid, lipid, nucleotide, and mitochondrial pathways, with emphasis on immune regulation. The review integrates mechanisms linking these pathways to tumor progression and therapy resistance, and profiles nanomaterial platforms that both deliver therapeutics and actively reprogram ...
Xiaosu Zhou, Ruibing Deng, Zunde Liao, Xiaoyu Huang, Junting Huang, Hanlou Yang, Kam W. Leong, Yiling Zhong   +7 more
wiley   +1 more source