Results 71 to 80 of about 3,610 (188)

Short-course eflornithine in Gambian trypanosomiasis: a multicentre randomized controlled trial

Bulletin of the World Health Organization, 2000
OBJECTIVE: A randomized controlled trial was conducted to determine whether 7 days of intravenous eflornithine (100 mg/kg every 6 h) was as effective as the standard 14-day regimen in the treatment of late-stage Trypanosoma brucei gambiense ...
Jacques Pépin, Nzambi Khonde, Faustine Maiso, Félix Doua, Shabbar Jaffar, Stéphane Ngampo, Bokelo Mpia, Dawson Mbulamberi, Felix Kuzoe   +8 more
doaj  

Human African trypanosomiasis in two historical foci of the estuaire province, gabon: A case report

SAGE Open Medical Case Reports, 2020
Human African Trypanosomiasis (HAT) is an infectious disease due to a protozoa parasite of the Trypanosoma genus. In West and Central Africa, this disease is caused by the subspecies Trypanosoma brucei gambiense .
Berthe Amélie Iroungou, Larson Boundenga, Laurette Guignali Mangouka, Berthold Bivigou-Mboumba, Jean Raymond Nzenze, Gael Darren Maganga   +5 more
doaj   +1 more source

Adaptation and therapeutic exploitation of the plasma membrane of African trypanosomes [PDF]

, 2018
African trypanosomes are highly divergent from their metazoan hosts, and as part of adaptation to a parasitic life style have developed a unique endomembrane system.
Canavate Del Pino, Ricardo, Field, Mark, Quintana , Juan F., Yamada, Kayo, Zhang, Ning   +4 more
core   +3 more sources

Exploration of Novel “Ferroxazide/Ferrazone” Derivatives as Antitrypanosomatid Agents: Design, Synthesis, and Biological Efficacy

Applied Organometallic Chemistry, Volume 39, Issue 1, January 2025.
A series of novel ferrocene derivatives, mimics of the clinical antibiotics, nifuroxazide and nitrofurazone, termed ferroxazides and ferrazones, respectively, were synthesized and evaluated for antitrypanosomatid activities. The ferroxazide 15 bearing dimethylamino moiety was identified in vitro as hit against Trypanosoma congolense strain but ...
Christina Kannigadu, Helena D. Janse van Rensburg, Janine Aucamp, Keisuke Suganuma, David D. N'Da   +4 more
wiley   +1 more source

Human colonic organoids for understanding early events of familial adenomatous polyposis pathogenesis

The Journal of Pathology, Volume 265, Issue 1, Page 26-40, January 2025.
Abstract Patients with familial adenomatous polyposis (FAP) harbor mutations in the APC gene and will develop adenoma and early colorectal cancer. There is no validated treatment, and animal models are not sufficient to study FAP. Our aim was to investigate the early events associated with FAP using the intestinal organoid model in a single‐center ...
Nolwenn Laborde, Alexandre Barusseaud, Muriel Quaranta, Corinne Rolland, Amélie Arrouy, Delphine Bonnet, Sylvain Kirzin, Nuria Sola‐Tapias, Dimitri Hamel, Karl Barange, Jean‐Pierre Duffas, Marie‐Pierre Gratacap, Julie Guillermet‐Guibert, Anne Breton, Nathalie Vergnolle, Laurent Alric, Audrey Ferrand, Frédérick Barreau, Claire Racaud‐Sultan, Emmanuel Mas   +19 more
wiley   +1 more source

Evaluation of pyrrolidine and pyrazolone derivatives as inhibitors of trypanosomal phosphodiesterase B1 (TbrPDEB1) [PDF]

, 2015
Author Posting. © The Author(s), 2015. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution.
Amata, Emanuele, Bland, Nicholas D., Campbell, Robert K., Pollastri, Michael P.   +3 more
core   +1 more source

Dermatological care of gender‐diverse patients in Australia

Australasian Journal of Dermatology, Volume 65, Issue 8, Page 601-609, December 2024.
Abstract In recent years, there has been an increasing recognition of the unique healthcare needs of gender‐diverse patients in Australia. With the continuous growth of referrals to gender health services, there is an increased demand for specialised dermatological care.
Roy Kingsley Wong, Jenny Harrington, Annabel Irene Stevenson   +2 more
wiley   +1 more source

Current and Future Prospects of Nitro-compounds as Drugs for Trypanosomiasis and Leishmaniasis [PDF]

, 2018
Interest in nitroheterocyclic drugs for the treatment of infectious diseases has undergone a resurgence in recent years. Here we review the current status of monocyclic and bicyclic nitroheterocyclic compounds as existing or potential new treatments for ...
Alan H. Fairlamb, Alliance T.B., Altcheh J., Andrade H.M., Andrade S.G., Andrade S.G., Andrews K.T., Ang C.W., Araldi R.P., Aubé J., Bahia M.T., Bahia M.T., Balasubramanian B., Barreto-Bergter E., Berriman M., Bisser S., Blumenstiel K., Boiani M., Brener Z., Bruhn D.F., Bustamante J.M., Campos M.C., Campos M.C., Chung M.C., Collins A.R., Darsaud A., de Andrade A.L., Deavall D.G., Dikhit M.R., Docampo R., Docampo R., Docampo R., Dodd M.C., Dogra M., El-Sayed N.M., Enanga B., Eperon G., Fabbro D.L., Fairlamb A.H., Fairlamb A.H., Fairlamb A.H., Fernández M.L., Ferreira R.C., Filardi L.S., Fonseca-Berzal C., Garavaglia P.A., Goijman S.G., Gupta S., Gurumurthy M., Hall B.S., Hall B.S., Hayashi M., Henderson G.B., Henderson G.B., Henriques C., Ivens A.C., Jacobs R.T., Janssens P.G., Jeganathan S., Jennings F.W., Kaiser M., Kubata B.K., Lewis M.D., Lewis M.D., Lewis M.D., Likeufack A.C.L., Maina N., Makarov V., Marin-Neto J.A., Marin-Neto J.A., Matsumoto M., Maya J.D., Mejia A.M., Mejía-Jaramillo A.M., Mesu V.K.B.K., Miura K., Moens F., Molina I., Moreno M., Moreno S.N.J., Morillo C.A., Morillo C.A., Mortelmans K., Mukherjee T., Mukkavilli R., Murta S.M., Murta S.M.F., Murta S.M.F., Neal R.A., Nesslany F., Nogoceke E., Nogueira F.B., Nogueira F.B., Olmo F., Panicucci R., Papadopoulou M.V., Papadopoulou M.V., Papadopoulou M.V., Patterson S., Patterson S., Patterson S., Portal P., Priotto G., Priotto G., Pépin J., Pépin J., Raether W., Repetto Y., Rodriques Coura J., Romero A.H., Ryan N.J., Sasahara K., Shimokawa Y., Singh R., Smith D.A., Sokolova A.Y., Stephen Patterson, Stover C.K., Stuart K., Tarleton R.L., Tarral A., Temperton N.J., Thompson A.M., Thompson A.M., Thompson A.M., Thompson A.M., Thompson A.M., Torreele E., Trochine A., Trochine A., Trunz B.B., Tweats D., Urbina J.A., Viodé C., Walsh J.S., Wilkinson S.R., Winkelmann E., Wyllie S., Wyllie S., Wyllie S., Wyllie S., Zhou L.   +141 more
core   +2 more sources

Characterization of the Link between Ornithine, Arginine, Polyamine and Siderophore Metabolism in Aspergillus fumigatus. [PDF]

PLoS ONE, 2013
The opportunistic fungal pathogen Aspergillus fumigatus produces siderophores for uptake and storage of iron, which is essential for its virulence. The main precursor of siderophore biosynthesis (SB), ornithine, can be produced from glutamate in the ...
Nicola Beckmann, Lukas Schafferer, Markus Schrettl, Ulrike Binder, Heribert Talasz, Herbert Lindner, Hubertus Haas   +6 more
doaj   +1 more source

Human African trypanosomiasis in endemic populations and travellers [PDF]

, 2018
Human African trypanosomiasis (HAT) or sleeping sickness is caused by the protozoan parasites Trypanosoma brucei (T.b.) gambiense (West African form) and T.b.
Blum, J., Hatz, C., Neumayr, A.
core