Results 81 to 90 of about 3,610 (188)
Evaluating 5-nitrofurans as trypanocidal agents [PDF]
, 2013 The nitroheterocycle nifurtimox, as part of a nifurtimox-eflornithine combination therapy, represents one of a limited number of treatments targeting Trypanosoma brucei, the causative agent of human African trypanosomiasis.
Alvarez, G +6 more
core +1 more source
Hydrazinated geraniol derivatives as potential broad‐spectrum antiprotozoal agents
Archiv der Pharmazie, Volume 357, Issue 10, October 2024.Hydrazinated geraniol derivatives were synthesised and tested in vitro against different parasitic protozoans of clinical relevance, including Trypanosoma brucei brucei, Trypanosoma brucei rhodesiense, Trypanosoma cruzi and Leishmania infantum. Compounds 6, 8, 13, 14 and 15 demonstrated low micromolar activity against the different parasites.
Joelien Jooste +4 more
wiley +1 more source
ChemistrySelect, Volume 9, Issue 35, September 18, 2024.A series of trifluoromethylthiolated cinnamate derivatives have demonstrated promising potential applications as topical antidermatophytic agents. In particular, two derivatives have a lower propensity for cytotoxicity at low concentrations and a low irritant potential profile, even at concentrations 6–30 times higher than the Minimum Inhibitory ...
Luana Candice Genz Bazana +8 more
wiley +1 more source
Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1997 De la difluorométhylornithine (DFMO, eflornithine) a été donnée par voie intraveineuse (lV) à des chiens infectés expérimentalement par Trypanosoma brucei.
B.M. Anene, S.M. Anika, C.C. Chukwu
doaj +1 more source
Metabolomics and lipidomics reveal perturbation of sphingolipid metabolism by a novel anti-trypanosomal 3-(oxazolo[4,5-b]pyridine-2-yl)anilide [PDF]
, 2016 Introduction: Trypanosoma brucei is the causative agent of human African trypanosomiasis, which is responsible for thousands of deaths every year. Current therapies are limited and there is an urgent need to develop new drugs.
Avery, Vicky M. +11 more
core +2 more sources
Medicinal Research Reviews, Volume 44, Issue 5, Page 2078-2111, September 2024.Abstract As the world population ages, there will be an increasing need for effective therapies for aging‐associated neurodegenerative disorders, which remain untreatable. Dementia due to Alzheimer's disease (AD) is one of the leading neurological diseases in the aging population.
Viswanath Das +6 more
wiley +1 more source
A 3D Bioprinted Human Neurovascular Unit Model of Glioblastoma Tumor Growth
Advanced Healthcare Materials, Volume 13, Issue 15, June 13, 2024.A high‐throughput amenable 3D bioprinted neurovascular unit (NVU) creates a patient‐derived glioblastoma (GBM) growth assay using human primary brain cells and patient‐derived GBM cells in a 96‐well plate with real‐time readouts of angiogenesis and GBM growth for drug screening.
Yen‐Ting Tung +5 more
wiley +1 more source
The challenging problem of disease staging in human African trypanosomiasis (sleeping sickness): a new approach to a circular question [PDF]
, 2017 Human African trypanosomiasis (HAT), also known as sleeping sickness, puts millions of people at risk in sub-Saharan Africa and is a neglected parasitic disease that is almost always fatal if untreated or inadequately treated. HAT manifests itself in two
Gettinby, George +2 more
core +1 more source
Polycystic ovary syndrome and risk of pre‐eclampsia: A national register‐based cohort study
BJOG: An International Journal of Obstetrics &Gynaecology, Volume 131, Issue 7, Page 985-995, June 2024.Abstract Objective To explore whether the association between polycystic ovary syndrome (PCOS) and pre‐eclampsia depends on treated clinical hyperandrogenism and whether PCOS is associated with different subtypes of pre‐eclampsia. Design Nationwide register‐based cohort study. Setting Sweden.
Ragnheidur Valdimarsdottir +7 more
wiley +1 more source