Chronic Diseases and Translational Medicine, EarlyView.PRISMA 2020 flow diagram of included studies. ABSTRACT Purpose Immune checkpoint inhibitors have transformed treatment strategies for metastatic non‐small cell lung cancer (mNSCLC). This study aimed to assess the efficacy and safety of durvalumab combined with tremelimumab compared with those of standard chemotherapy, particularly in patients with low ...
Ikhwan Rinaldi +2 more
wiley +1 more source
Correction to: Public assistance and survival equality in patients with EGFR mutation-positive lung cancer. [PDF]
Jpn J Clin Oncoleuropepmc +1 more source
CT-based nomogram for predicting EGFR mutation status in ground-glass nodules of lung adenocarcinoma. [PDF]
Front ImmunolLi L +10 more
europepmc +1 more source
Cancer Nexus, EarlyView.ABSTRACT Objective This single‐center retrospective cohort study evaluated whether, among patients with stage IV cancer who participated in a pragmatic “alkalization therapy”—defined as a low potential renal acid load diet plus oral sodium bicarbonate and/or potassium/sodium citrate—urinary pH was associated with long‐term survival.
Shion Kachi +5 more
wiley +1 more source
Prediction of EGFR mutation status in non-small cell lung cancer based on multiparametric MRI radiomics. [PDF]
BMC Med ImagingWang Y +10 more
europepmc +1 more source
Toward Fit‐for‐Purpose Data for Drug Assessment in Non‐small Cell Lung Cancer: A Core Dataset
Clinical Pharmacology &Therapeutics, EarlyView.Considering the high unmet medical need in people with non‐small cell lung cancer (NSCLC), the drug assessment for targeted therapies often rely on small populations and single‐arm trials, challenging the evaluation by regulatory authorities, health technology assessment bodies (HTAb), and clinicians.
Geeske F. Grit +6 more
wiley +1 more source
Non-enzymatic function of QSOX2 directly regulates the JUNB-ITGB4 axis and enhanced resistance to osimertinib in EGFR-mutation lung adenocarcinoma. [PDF]
Cell Death DiscovLiu C +11 more
europepmc +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Exposure‐response analyses supported a favorable benefit‐risk profile of Dato‐DXd at 6 mg/kg Q3W in patients with advanced nonsquamous NSCLC. Datopotamab deruxtecan (Dato‐DXd) is a trophoblast cell‐surface antigen‐2 (TROP2)‐directed antibody‐drug conjugate (ADC) that has demonstrated clinical activity in patients with NSCLC who have received prior ...
Ying Hong +10 more
wiley +1 more source
Liquid Biopsy for EGFR Mutation Detection in NSCLC: Evaluation of Plasma ctDNA and Comparison with Plasma exoDNA. [PDF]
Iran Biomed JMashayekhi P +5 more
europepmc +1 more source
Drosophila male genitalia rotation depends on permissive remodeling of the posterior abdomen
Developmental Dynamics, EarlyView.Abstract Background One of the most characteristic morphogenetic processes in Drosophila is the 360° rotation of the male pupal genital disc. This movement is driven by the myosin Myo1D, whose expression in the genital disc is controlled by the Hox gene Abdominal‐B (Abd‐B).
Nuria Prieto +6 more
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