Results 51 to 60 of about 71,588 (336)

Malarial proteases and host cell egress: an 'emerging' cascade. [PDF]

, 2008
Malaria is a scourge of large swathes of the globe, stressing the need for a continuing effort to better understand the biology of its aetiological agent. Like all pathogens of the phylum Apicomplexa, the malaria parasite spends part of its life inside a
Blackman, Michael J
core   +1 more source

An Extracellular Redox Signal Triggers Calcium Release and Impacts the Asexual Development of Toxoplasma gondii

Frontiers in Cellular and Infection Microbiology, 2021
The ability of an organism to sense and respond to environmental redox fluctuations relies on a signaling network that is incompletely understood in apicomplexan parasites such as Toxoplasma gondii.
Eduardo Alves, Henry J. Benns, Henry J. Benns, Lilian Magnus, Caia Dominicus, Tamás Dobai, Joshua Blight, Ceire J. Wincott, Matthew A. Child   +8 more
doaj   +1 more source

Egress of Alphaherpesviruses [PDF]

Journal of Virology, 2006
In their recent papers on the assembly of alphaherpesviruses, Wild et al. ([13][1]) and Leuzinger et al. ([3][2]) propose that the egress of herpesvirus capsids from the nucleus and formation of the enveloped herpesvirus virion occur by two alternative routes.
Thomas C. Mettenleiter, Tony Minson
openaire   +1 more source

The host exosome pathway underpins biogenesis of the human cytomegalovirus virion

eLife, 2020
Human Cytomegalovirus (HCMV) infects over half the world's population, is a leading cause of congenital birth defects, and poses serious risks for immuno-compromised individuals.
Declan L Turner, Denis V Korneev, John G Purdy, Alex de Marco, Rommel A Mathias   +4 more
doaj   +1 more source

Bunyavirus SFTSV exploits autophagic flux for viral assembly and egress

Autophagy, 2021
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging negatively stranded enveloped RNA bunyavirus that causes SFTS with a high case fatality rate of up to 30%.
Jia-Min Yan, Wen-kang Zhang, Li-na Yan, Yong-jun Jiao, Chuan-Min Zhou, Xue-Jie Yu   +5 more
semanticscholar   +1 more source

Phosphoinositide metabolism links cGMP-dependent protein kinase G to essential Ca²⁺ signals at key decision points in the life cycle of malaria parasites [PDF]

, 2014
This work was funded by grants from the Wellcome Trust (WT098051 and 079643/Z/06/Z) and the Medical Research Council (G0501670) to OB, a Wellcome Trust project grant to DB (WT094752), a Wellcome Trust Grant (WT093228) to TKS, a Marie Curie Fellowship ...
Katrin Volkmann, Chappell, Lia, Brochet, M., Oliver Billker, Eloise Thompson, Billker, Oliver,, Mathieu Brochet, Berriman, Matthew, Jyoti Choudhary (261900), Frank Schwach, Rayner, Julian C., Rayner, Julian C, Jyoti Choudhary, Lia Chappell (530631), Sebastian, Sarah, Lia Chappell, Chappell, L., Terry K. Smith (112550), Gomes, Ana Rita, Frank Schwach (530630), Ana Rita Gomes, Oliver Billker (92636), Smith, T.K., Thompson, E., Schwach, F., Sebastian, S., Baker, David A, Volkmann, K., Sarah Sebastian (530629), Volkmann, Katrin, David A Baker, Terry K Smith, Ana Rita Gomes (220735), Collins, Mark O., Smith, Terry K., Mark O Collins, Gomes, A.R., Collins, M.O., David A. Baker (122252), Choudhary, J., Julian C Rayner, Brochet, Mathieu, Mathieu Brochet (149272), Billker, Oliver, Collins, Mark O, Mark O. Collins (131229), Billker, O., Schwach, Frank, Berriman, M., Sarah Sebastian, Rayner, J.C., Matthew Berriman (5353), Baker, David A., Thompson, Eloise, Smith, Terry K, Matthew Berriman, Choudhary, Jyoti, Eloise Thompson (376344), Baker, D.A., Julian C. Rayner (121198), Katrin Volkmann (149256)   +60 more
core   +1 more source

Calcium-Dependent Protein Kinase 5 Is Required for Release of Egress-Specific Organelles in Plasmodium falciparum

mBio, 2018
The human malaria parasite Plasmodium falciparum requires efficient egress out of an infected red blood cell for pathogenesis. This egress event is highly coordinated and is mediated by several signaling proteins, including the plant-like P.
Sabrina Absalon, Karin Blomqvist, Rachel M. Rudlaff, Travis J. DeLano, Michael P. Pollastri, Jeffrey D. Dvorin   +5 more
doaj   +1 more source

iTRAQ-Based Phosphoproteomic Analysis of Toxoplasma gondii Tachyzoites Provides Insight Into the Role of Phosphorylation for its Invasion and Egress

Frontiers in Cellular and Infection Microbiology, 2020
The invasion and egress are two key steps in lytic cycle vital to the propagation of Toxoplasma gondii infection, and phosphorylation is believed to play important roles in these processes. However, the phosphoproteome of T.
Cheng He, Mei-zhen Xu, Shuai Pan, Hui Wang, Hong-juan Peng, Zhuan-zhuan Liu   +5 more
doaj   +1 more source

NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress

Nature Communications, 2019
Transport of dietary cholesterol from endocytic organelles to the endoplasmic reticulum (ER) is essential for cholesterol homoeostasis, but the mechanism and regulation of this transport remains poorly defined.
D. Höglinger, T. Burgoyne, E. Sanchez-Heras, P. Hartwig, A. Colaco, J. Newton, C. Futter, S. Spiegel, F. Platt, E. R. Eden   +9 more
semanticscholar   +1 more source

Epstein-Barr Virus Exploits the Secretory Pathway to Release Virions

Microorganisms, 2020
Herpesvirus egress mechanisms are strongly associated with intracellular compartment remodeling processes. Previously, we and other groups have described that intracellular compartments derived from the Golgi apparatus are the maturation sites of Epstein-
Asuka Nanbo
doaj   +1 more source