Results 111 to 120 of about 33,480 (278)

Disruption of FADS2 gene in mice impairs male reproduction and causes dermal and intestinal ulceration

Journal of Lipid Research, 2009
Delta-6 desaturase (D6D) catalyzes the first step in the synthesis of highly unsaturated fatty acids (HUFA) such as arachidonic (AA), docosapentaenoic (DPAn-6), and docosahexaenoic (DHA) acids, as well as the last desaturation of DPAn-6 and DHA.
Chad K. Stroud, Takayuki Y. Nara, Manuel Roqueta-Rivera, Emily C. Radlowski, Peter Lawrence, Ying Zhang, Byung H. Cho, Mariangela Segre, Rex A. Hess, J. Thomas Brenna, Wanda M. Haschek, Manabu T. Nakamura   +11 more
doaj  

Advancements in Ambient Ionisation Mass Spectrometry in 2024: An Annual Review

Analytical Science Advances, Volume 6, Issue 1, June 2025.
ABSTRACT The introduction of ambient ionisation mass spectrometry (AIMS) is among the most important developments in analytical chemistry in recent years. Enabling the direct analysis of samples in their native state with neither sample preparation nor chromatographic separation provides chemical characterisation in a matter of seconds.
Alisha Henderson, Liam M. Heaney, Stephanie Rankin‐Turner   +2 more
wiley   +1 more source

Thromboxane A synthase-independent production of 12-hydroxyheptadecatrienoic acid, a BLT2 ligand[S]

Journal of Lipid Research, 2013
12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid (12-HHT) has long been considered a by-product of thromboxane A2 (TxA2) biosynthesis with no biological activity.
Takehiko Matsunobu, Toshiaki Okuno, Chieko Yokoyama, Takehiko Yokomizo   +3 more
doaj  

Vascular responsiveness and eicosanoid production in diabetic rats [PDF]

, 1983
David M. Roth, Diane Reibel, Allan M. Lefer   +2 more
openalex   +1 more source

Single‐cell sequencing reveals a regulatory role of WT1 in mast cell proliferation in endometrial polyps

The FASEB Journal, Volume 39, Issue 9, 15 May 2025.
We used single‐cell and bulk RNA sequencing to analyze ectopic endometrial polyps (EPs) and adjacent eutopic endometrial tissues (EUs), identifying alterations in cell composition and transcriptional dynamics. Notably, mast cells showed increased activation with distinct transcriptional changes.
Yu Lin, Yiwen Qi, Yutong Yao, Huan Tong, Lan Chen, Weizhou Song, Guojing Li, Hong Xu, Xiaoying He   +8 more
wiley   +1 more source

PGE2 release is independent of upregulation of Group V phospholipase A2 during long-term stimulation of P388D1 cells with LPS1

Journal of Lipid Research, 2005
P388D1 cells release arachidonic acid (AA) and produce prostaglandin E2 (PGE2) upon long-term stimulation with lipopolysaccharide (LPS). The cytosolic Group IVA (GIVA) phospholipase A2 (PLA2) has been implicated in this pathway.
Ursula A. Kessen, Ralph H. Schaloske, Daren L. Stephens, Karin Killermann Lucas, Edward A. Dennis   +4 more
doaj  

Polyunsaturated fatty acids and inflammation

Oléagineux, Corps gras, Lipides, 2004
The n-6 polyunsaturated fatty acid arachidonic acid gives rise to the eicosanoid family of inflammatory mediators (prostaglandins, leukotrienes and related metabolites) and through these regulates the activities of inflammatory cells, the production of ...
Calder Philip C.
doaj   +1 more source

A phospholipase A2-activating protein (PLAP) stimulates human neutrophil aggregation and release of lysosomal enzymes, superoxide, and eicosanoids. [PDF]

, 1989
John S. Bomalaski, Daniel G. Baker, L Brophy, N. V. Resurreccion, Isaias Spilberg, Miguel A. Muniain, M A Clark   +6 more
openalex   +1 more source

A Case Study of a Female Infant With Primary Hypertrophic Osteoarthropathy Demonstrates That Early Initiation of Celecoxib Slows but Does Not Prevent Symptom Progression

American Journal of Medical Genetics Part A, Volume 197, Issue 5, May 2025.
ABSTRACT Primary Hypertrophic Osteoarthropathy (PHOAR1) is characterized by autosomal recessive loss of function variants in 15‐hydroxyprostaglandin dehydrogenase (HPGD) leading to digital clubbing, periostosis, pachydermia, and severe hyperhidrosis. HPGD catalyzes the first step of prostaglandin E2 (PGE2) degradation.
Kara Zehr, Morgan Buckley, Joshua W. Owens, Tomas Vanagunas, Patricia Vega Fernandez, Robert J. Hopkin, Amelle Shillington   +6 more
wiley   +1 more source

Maternal IgE Influence on Fetal and Infant Health

Immunological Reviews, Volume 331, Issue 1, May 2025.
ABSTRACT Immunoglobulin E (IgE) is the most recently discovered and evolved mammalian antibody type, best known for interacting with mast cells (MCs) as immune effectors. IgE‐mediated antigen sensing by MC provides protection from parasites, venomous animals, bacteria, and other insults to barrier tissues exposed to the environment.
Jozef Balla, Abhay P. S. Rathore, Ashley L. St. John   +2 more
wiley   +1 more source