Results 111 to 120 of about 33,906 (210)

A novel role for activating transcription factor-2 in 15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis*

Journal of Lipid Research, 2009
To investigate the mechanisms underlying 15(S)-HETE-induced angiogenesis, we have studied the role of the small GTPase, Rac1. We find that 15(S)-HETE activated Rac1 in human retinal microvascular endothelial cells (HRMVEC) in a time-dependent manner ...
Tieqiang Zhao, Dong Wang, Sergey Y. Cheranov, Manjula Karpurapu, Koteswara R. Chava, Venkatesh Kundumani-Sridharan, Dianna A. Johnson, John S. Penn, Gadiparthi N. Rao   +8 more
doaj   +1 more source

Antibiotic‐mediated immune modulation in periodontitis

Periodontology 2000, EarlyView.
Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez, R. M. Arce, Camila Pinheiro Furquim, Cristiane Gonçalves, Alpdogan Kantarci, Magda Feres, Nidia C. Castro dos Santos   +6 more
wiley   +1 more source

Synopsis: Special Issue on “Disruption of signaling homeostasis induced crosstalk in the carcinogenesis paradigm Epistemology of the origin of cancer”

4 open, 2019
It is increasingly evident that carcinogenesis, in the vast majority of cancers, cannot be explained simply through an accumulation of somatic mutations, or epigenetics, the stem cell theory, or the Warburg effect.
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

Excessive hypercholesterolaemia during pregnancy as a risk factor for endothelial dysfunction in pre‐eclampsia

The Journal of Physiology, EarlyView.
Abstract figure legend Excessive hypercholesterolaemia during pregnancy impairs maternal endothelial function, which, in turn, drives the development of pre‐eclampsia and may also contribute to the increased risk of later‐life cardiovascular disease in women.
Amanda A. de Oliveira, Floor Spaans, Christy‐Lynn M. Cooke, Sandra T. Davidge   +3 more
wiley   +1 more source

Mitochondrial control of ciliary gene expression and structure in striatal neurons

The Journal of Physiology, EarlyView.
Abstract figure legend Neurons drive animal behaviour by receiving and transmitting information and require energy, primarily supplied by mitochondria, to function. Additionally, neurons need to sense environmental changes to adapt, a function that is locally played by the primary cilia.
Dogukan H. Ulgen, Alessandro Chioino, Olivia Zanoletti, Albert Quintana, Elisenda Sanz, Carmen Sandi   +5 more
wiley   +1 more source

The proteomic differences and expression of fatty acid‐binding protein 6 (FABP6) associated with gastrointestinal injury in horses with oral administration of a clinical dose of phenylbutazone

Equine Veterinary Journal, Volume 58, Issue 3, Page 845-856, May 2026.
Abstract Background Phenylbutazone (PBZ) can potentially induce gastrointestinal ulceration, and early detection of PBZ‐induced gastroenteropathy will be useful for the diagnosis, treatment, and prevention of PBZ toxicity. Objectives To identify putative proteins associated with equine gastric ulcer syndrome after clinical dose (4.4 mg/kg ...
Ruethaiwan Vinijkumthorn, Nawarus Prapaiwan, Thanapon Chotikaprakal, Phirom Prompiram, Narumon Phaonakrop, Sittiruk Roytrakul, Parichart Tesena   +6 more
wiley   +1 more source

Radioiodination of Two Carborane‐Based Dual Cyclooxygenase‐2/5‐Lipoxygenase Inhibitors and Their In Vitro and In Vivo Evaluation

ChemBioChem, Volume 27, Issue 7, 14 April 2026.
Two dicarbadodecaborane(12)‐based dual cyclooxygenase‐2/5‐lipoxygenase (COX‐2/5‐LO) inhibitors were 123I‐labeled. Refinement of labeling and formulation conditions and extensive in vitro characterization are presented. Cell uptake studies in COX‐2‐ and 5‐LO‐overexpressing cell lines showed COX‐2‐independent and partly 5‐LO‐dependent uptake.
Jonas Schädlich, Martin Ullrich, Cathleen Haase‐Kohn, Robert Wodtke, Sebastian Braun, Maximilian Molitor, Bettina Hofmann, Dieter Steinhilber, Klaus Kopka, Evamarie Hey‐Hawkins, Jens Pietzsch, Markus Laube   +11 more
wiley   +1 more source

Mechanisms of Aristolochic Acid Resistance in Specialist Butterflies and Evolutionary Insights for Potential Protective Pathways

Advanced Science, Volume 13, Issue 19, 2 April 2026.
The study provides an extreme example of insect adaptation to highly toxic defenses of host plants, and investigates the complex strategies to resist carcinogenic aristolochic acids, including physical isolation, metabolic detoxification, and DNA repair.
Yang Luan, Yubo Zhang, Jingjing Li, Jianqing Zhu, Yuyang Lei, Yushi Hu, Zhenqiang Xin, Tianpei Xie, Jiang Zheng, Yuanyuan Lin, Jingjing Shen, Yiyi Cao, Xinyue You, Jing Xi, Jiaying Wu, Weiying Liu, Xinyu Zhang, Yuanting Zheng, David J. Lohman, Leming Shi, Wei Zhang   +20 more
wiley   +1 more source

Lipid Metabolism and Obesity in Early Life: Drivers of Chronic Lung Disease From Development to Adulthood

Molecular Nutrition &Food Research, Volume 70, Issue 7, 15 April 2026.
Metabolic and nutritional stressors are a growing global health concern. This review discusses how obesity, lipids, and lipid derivatives influence lung development, homeostasis, and chronic lung disease progression, highlighting roles of alveolar surfactant and sphingolipids.
Jaco Selle, Natascha Mierswa, Leon Saschin, Jana Niehues, Jörg Dötsch, Eva Nüsken, Kai‐Dietrich Nüsken, Julia Schipke, Miguel A. Alejandre Alcazar   +8 more
wiley   +1 more source

In Silico, In Vitro, and In Vivo Antinociceptive Potential of S‐Naproxen Derivatives

ChemistryOpen, Volume 15, Issue 4, April 2026.
Selected naproxen derivatives were investigated for their antinociceptive effects, using in vitro (COX‐I/COX‐II antagonistic effect), in vivo (acetic acid and hot plate assay), and in silico (molecular simulation studies) approaches. The COX inhibition studies revealed that the maximum percent effect exhibited by GMO‐I‐111a 96.01 and 92% against COX‐2 ...
Ubaidullah, Naveed Muhammad, Abad Khan, Rahaf Ajaj, Abdur Rauf, Umer Rashid, Fahad Hussain, Rashid Khan, Faiza Seraj, Uzma Uzma, Basharat Ali, Abdul Sadiq, Khalid Mohammed Khan, Marcello Iriti   +13 more
wiley   +1 more source