Results 41 to 50 of about 33,480 (278)
Nature Reviews Cancer, 2010 Eicosanoids, including prostaglandins and leukotrienes, are biologically active lipids that have been implicated in various pathological processes, such as inflammation and cancer. This Review highlights our understanding of the intricate roles of eicosanoids in epithelial-derived tumours and their microenvironment.
Raymond N. DuBois, Dingzhi Wang
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Total synthesis of the endogenous inflammation resolving lipid resolvin D2 using a common lynchpin
Beilstein Journal of Organic Chemistry, 2013 The total synthesis of the endogenous inflammation resolving eicosanoid resolvin D2 (1) is described. The key steps involved a Wittig reaction between aldehyde 5 and the ylide derived from phosphonium salt 6 to give enyne 17 and condensation of the same ...
John Li +3 more
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Prostanoid Metabolites as Biomarkers in Human Disease
Metabolites, 2022 Prostaglandins (PGD2, PGE2, PGF2α), prostacyclin (PGI2), and thromboxane A2 (TXA2) together form the prostanoid family of lipid mediators. As autacoids, these five primary prostanoids propagate intercellular signals and are involved in many physiological
Helena Idborg, Sven-Christian Pawelzik
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Eicosanoids in carcinogenesis [PDF]
4open, 2019 Inflammation is the body's reaction to pathogenic (biological or chemical) stimuli and covers a burgeoning list of compounds and pathways that act in concert to maintain the health of the organism. Eicosanoids and related fatty acid derivatives can be formed from arachidonic acid and other polyenoic fatty acids via the cyclooxygenase and lipoxygenase ...
Björn L.D.M. Brücher, Ijaz S. Jamall
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Membranes, 2023 There has been an almost exponential increase in the use of molecular dynamics simulations in basic research and industry over the last 5 years, with almost a doubling in the number of publications each year.
Stephan L. Watkins
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Regulation of Eicosanoid Pathways by MicroRNAs
Frontiers in Pharmacology, 2019 Over the last years, many microRNAs (miRNAs) have been identified that regulate the formation of bioactive lipid mediators such as prostanoids and leukotrienes.
Meike J. Saul +3 more
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S1R agonist modulates rat platelet eicosanoid synthesis and aggregation
Platelets, 2022 Sigma-1 receptor (S1R) is detected in different cell types and can regulate intracellular signaling pathways. S1R plays a role in the pathomechanism of diseases and the regulation of neurotransmitters. Fluvoxamine can bind to S1R and reduce the serotonin
Sándor Váczi +12 more
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A review on the role of fatty acids in colorectal cancer progression
Frontiers in Pharmacology, 2022 Colorectal cancer (CRC) is the third leading cause of mortality in cancer patients. The role of fatty acids (FA) and their metabolism in cancer, particularly in CRC raises a growing interest.
Malvina Hoxha, Bruno Zappacosta
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House dust mite drives proinflammatory eicosanoid reprogramming and macrophage effector functions
Allergy. European Journal of Allergy and Clinical Immunology, 2018 Eicosanoid lipid mediators play key roles in type 2 immune responses, for example in allergy and asthma. Macrophages represent major producers of eicosanoids and they are key effector cells of type 2 immunity. We aimed to comprehensively track eicosanoid
Fiona D. R. Henkel +11 more
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Journal of Pathology, 2018 Eicosanoids comprise a diverse group of bioactive lipids which orchestrate inflammation, immunity, and tissue homeostasis, and whose dysregulation has been implicated in carcinogenesis.
M. Cummings +12 more
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