Results 51 to 60 of about 33,480 (278)

RNF112 Facilitates Ubiquitin‐Mediated Degradation of c‐Myc, Suppressing Proliferation, Migration and Lipid Synthesis in Bladder Cancer

Advanced Science, EarlyView.
RNF112, an E3 ubiquitin ligase, is markedly reduced in bladder cancer (BLCA). It curbs BLCA cell proliferation, migration, and lipid production primarily by enhancing ubiquitin‐dependent degradation of c‐Myc. This degradation inhibits c‐Myc's role in upregulating ACLY, a crucial enzyme for lipid synthesis, highlighting RNF112's potential as a ...
Kangping Xiong, Siming Chen, Huimin Xu, Sheng Tu, Hong Weng, Yejinpeng Wang, Mingxing Li, Jingtian Yu, Kaiyu Qian, Lingao Ju, Yi Zhang, Yu Xiao, Xinghuan Wang, Gang Wang   +13 more
wiley   +1 more source

Inhibitors of Human 5-Lipoxygenase Potently Interfere With Prostaglandin Transport

Frontiers in Pharmacology, 2022
5-Lipoxygenase (5-LO) is the key enzyme in the formation of pro-inflammatory leukotrienes (LT) which play an important role in a number of inflammatory diseases.
Astrid S. Kahnt, Carlo Angioni, Tamara Göbel, Bettina Hofmann, Jessica Roos, Jessica Roos, Svenja D. Steinbrink, Florian Rörsch, Dominique Thomas, Gerd Geisslinger, Kai Zacharowski, Sabine Grösch, Dieter Steinhilber, Thorsten J. Maier, Thorsten J. Maier   +14 more
doaj   +1 more source

Nuclear Translocation of S100A9 Triggers Senescence of Human Amnion Fibroblasts by De‐Repressing LINE1 Via Heterochromatin Erosion at Parturition

Advanced Science, EarlyView.
This study shows that the classical secretory protein S100 calcium‐binding protein A9 (S100A9) can translocate to the nucleus upon de‐phosphorylation at Thr 113 in human amnion fibroblasts at parturition, where S100A9 induces heterochromatin erosion through segregation of the heterochromatin maintenance protein, resulting inLong Interspersed Nuclear ...
Fan Zhang, Meng‐Die Li, Fan Pan, Wen‐Jia Lei, Yang Xi, Li‐Jun Ling, Leslie Myatt, Kang Sun, Wang‐Sheng Wang   +8 more
wiley   +1 more source

Eicosanoid biosynthesis influences the virulence of Candida parapsilosis

Virulence, 2018
Lipid mediators, derived from arachidonic acid metabolism, play an important role in immune regulation. The functions of bioactive eicosanoids range from modulating cytokine signaling and inflammasome formation to anti-inflammatory and pro-resolving ...
T. Chakraborty, Ernst Thuer, M. Heijink, R. Tóth, L. Bodai, C. Vágvölgyi, M. Giera, T. Gabaldón, A. Gácser   +8 more
semanticscholar   +1 more source

Paired Hierarchical Organization of 13-Lipoxygenases in Arabidopsis

Plants, 2016
Embryophyte genomes typically encode multiple 13-lipoxygenases (13-LOXs) that initiate the synthesis of wound-inducible mediators called jasmonates. Little is known about how the activities of these different LOX genes are coordinated.
Adeline Chauvin, Aurore Lenglet, Jean-Luc Wolfender, Edward E. Farmer   +3 more
doaj   +1 more source

Metabolomics and eicosanoid analysis identified serum biomarkers for distinguishing hepatocellular carcinoma from hepatitis B virus-related cirrhosis

OncoTarget, 2017
Hepatocellular carcinoma (HCC) is one of the most common cancers in the world. It is a type of inflammation-related cancer that usually follows liver hepatitis that mostly caused by hepatitis B virus (HBV) in China. However, the metabolism disturbance of
Zhi-Gang Gong, Weijie Zhao, Jianbing Zhang, Xi Wu, Jing Hu, Guo-Chang Yin, Yong-Jiang Xu   +6 more
semanticscholar   +1 more source

Flux Sampling Suggests Metabolic Signatures of High Antibody‐Producing CHO Cells

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Chinese hamster ovary (CHO) cells remain the industry standard for producing numerous therapeutic proteins, particularly monoclonal antibodies (mAbs). However, achieving higher recombinant protein titers remains an ongoing challenge and a fundamental understanding of the cellular mechanism driving improved bioprocess performance remains ...
Kate E. Meeson, Joanne Watson, Susan Rosser, Ellie Hawke, Andrew Pitt, Tessa Moses, Leon Pybus, Magnus Rattray, Alan J. Dickson, Jean‐Marc Schwartz   +9 more
wiley   +1 more source

Seasonal changes in eicosanoid metabolism in the brown bear

SCIENCE NATURE, 2018
Polyunsaturated fatty acids (PUFAs) exert several important functions across organ systems. During winter, hibernators divert PUFAs from oxidation, retaining them in their tissues and membranes, to ensure proper body functions at low body temperature ...
Sylvain Giroud, Alina L. Evans, I. Chery, F. Bertile, G. Tascher, J. Bertrand-Michel, G. Gauquelin‐Koch, J. Arnemo, J. Swenson, E. Lefai, S. Blanc, C. Simon   +11 more
semanticscholar   +1 more source

Lipid Metabolism and Immune Function: Chemical Tools for Insights into T‐Cell Biology

ChemBioChem, EarlyView.
This review explores how lipids regulate immune responses, particularly in T‐cell function. Advances in metabolomics and proteomics provide insights into lipid‐mediated immunity. Fluorescent lipids enable single‐cell analysis of lipid uptake and metabolism.
Luuk Reinalda, Mario van der Stelt, Sander Izaak van Kasteren   +2 more
wiley   +1 more source

Eicosanoid Mediators in the Airway Inflammation of Asthmatic Patients: What is New?

Allergy Asthma and Immunology Research, 2016
Lipid mediators contribute to inflammation providing both pro-inflammatory signals and terminating the inflammatory process by activation of macrophages.
M. Sanak
semanticscholar   +1 more source