Results 71 to 80 of about 33,480 (278)
Convergence of eicosanoid and integrin biology: 12-lipoxygenase seeks a partner
Molecular Cancer, 2015 BackgroundIntegrins and enzymes of the eicosanoid pathway are both well-established contributors to cancer. However, this is the first report of the interdependence of the two signaling systems.
K. Tang +8 more
semanticscholar +1 more source
Eicosanoids in tissue repair [PDF]
Immunology & Cell Biology, 2019 AbstractTrauma or infection can result in tissue damage, which needs to be repaired in a well‐orchestrated manner to restore tissue function and homeostasis. Lipid mediators derived from arachidonic acid (termed eicosanoids) play central and versatile roles in the regulation of tissue repair. Here, I summarize the current state‐of the‐art regarding the
openaire +4 more sources
Cannabinoids and the Endocannabinoid System in the Treatment of Chronic Rhinosinusitis
The Laryngoscope, EarlyView.The objective of this scoping review is to explore the role of the ECS in the pathophysiology of CRS. We identified five studies, all supporting a common conclusion that the ECS is implicated in regulating cellular inflammatory pathways potentially involved in sinonasal disease.
John J. W. Lee +7 more
wiley +1 more source
Journal of Lipid Research, 2015 To determine how the level of dietary n-6 PUFA affects the rate of loss of arachidonic acid (ARA) and DHA in brain phospholipids, male rats were fed either a deprived or adequate n-6 PUFA diet for 15 weeks postweaning, and then subjected to an ...
Lauren E. Lin +5 more
doaj
Eicosanoid pathway in colorectal cancer: Recent updates.
World Journal of Gastroenterology, 2015 Enzymatic metabolism of the 20C polyunsaturated fatty acid (PUFA) arachidonic acid (AA) occurs via the cyclooxygenase (COX) and lipoxygenase (LOX) pathways, and leads to the production of various bioactive lipids termed eicosanoids.
S. Tunçer, Sreeparna Banerjee
semanticscholar +1 more source
Lipids, EarlyView.Abstract Previous in vitro studies have indicated that oxidized phytosterol (OPS) exhibits some toxicity; however, the harmful effects of OPS on fatty acid metabolism are not completely understood yet. Therefore, this study examined the effects of exogenous phytosterol (PS) and OPS on growth parameters and lipid metabolism in rats.
Tomonari Koyama, Kyoichi Osada
wiley +1 more source
Journal of Lipid Research, 2014 Cytochrome P450 (CYP)-dependent metabolites of arachidonic acid (AA) contribute to the regulation of cardiovascular function. CYP enzymes also accept EPA and DHA to yield more potent vasodilatory and potentially anti-arrhythmic metabolites, suggesting ...
R. Fischer +12 more
semanticscholar +1 more source
Adipose triglyceride lipase regulates eicosanoid production in activated human mast cells
Journal of Lipid Research, 2014 Human mast cells (MCs) contain TG-rich cytoplasmic lipid droplets (LDs) with high arachidonic acid (AA) content. Here, we investigated the functional role of adipose TG lipase (ATGL) in TG hydrolysis and the ensuing release of AA as substrate for ...
A. Dichlberger +4 more
semanticscholar +1 more source
Immunomodulatory Effects of Omega‐3 Fatty Acids: Mechanistic Insights and Health Implications
Molecular Nutrition &Food Research, EarlyView.Omega‐3 fatty acids, derived from dietary sources and supplements, serve as bioactive precursors (ALA, EPA, DHA) that integrate into immune cell membranes. These fatty acids enhance cell membrane fluidity, improve immune cell communication, and modulate key transcription factors like NF‐κB.
Mahmut Bodur +3 more
wiley +1 more source
Journal of Lipid Research, 2014 In these studies, the role of ceramide-1-phosphate (C1P) in the wound-healing process was investigated. Specifically, fibroblasts isolated from mice with the known anabolic enzyme for C1P, ceramide kinase (CERK), ablated (CERK−/− mice) and their wild ...
D. Wijesinghe +9 more
semanticscholar +1 more source