Results 11 to 20 of about 65,238 (230)
Current Neuropharmacology, 2015 Arachidonic acid (AA)-derived lipid mediators are called eicosanoids. Eicosanoids have emerged as key regulators of a wide variety of physiological responses and pathological processes, and control important cellular processes.
Kunio Yui, Hiroyuki Nakamura
exaly +2 more sources
Cytosolic Phospholipase A2α and Eicosanoids Regulate Expression of Genes in Macrophages Involved in Host Defense and Inflammation [PDF]
, 2013 Acknowledgments: We thank Dr. Robert Barkley and Charis Uhlson for mass spectrometry analysis. Funding: This work was supported by grants from the National Institutes of Health HL34303 (to C.C.L., R.C.M. and D.L.B), DK54741 (to J.V.B.), GM5322 (to D.L.W.)
Bonventre, Joseph V. +9 more
core +14 more sources
Control of Coronary Vascular Resistance by Eicosanoids via a Novel GPCR.
American Journal of Physiology - Cell Physiology, 2022 Arachidonic acid metabolites epoxyeicosatrienoates (EETs) and hydroxyeicosatetraenoates (HETEs) are important regulators of myocardial blood flow and coronary vascular resistance (CVR), but their mechanisms of action are not fully understood.
N. Alkayed +14 more
semanticscholar +1 more source
Infection and Immunity, 2021 Eicosanoids are lipid-based signaling molecules that play a unique role in innate immune responses. The multiple types of eicosanoids, such as prostaglandins (PGs) and leukotrienes (LTs), allow the innate immune cells to respond rapidly to bacterial ...
Austin E. F. Sheppe, Mariola J. Edelmann
semanticscholar +1 more source
The association between eicosanoids and incident atrial fibrillation in the Framingham Heart Study
Scientific Reports, 2022 Chronic inflammation is a continuous low-grade activation of the systemic immune response. Whereas downstream inflammatory markers are associated with atrial fibrillation (AF), upstream inflammatory effectors including eicosanoids are less studied.
Jelena Kornej +11 more
doaj +1 more source
Stress, inflammation, and eicosanoids: an emerging perspective
Cancer and Metastasis Reviews, 2018 Sujanitha Umamaheswaran +2 more
exaly +2 more sources
Scientific Reports, 2021 The association between matrix metalloproteinases (MMPs), tissue inhibitor of metalloproteinases (TIMPs) and obesity as well as obesity-related disease including metabolic syndrome is not fully explored.
Soumaya Boumiza +5 more
doaj +1 more source
Eicosanoid profiling in an orthotopic model of lung cancer progression by mass spectrometry demonstrates selective production of leukotrienes by inflammatory cells of the microenvironment. [PDF]
PLoS ONE, 2013 Eicosanoids are bioactive lipid mediators derived from arachidonic acid(1) (AA), which is released by cytosolic phospholipase A2 (cPLA2). AA is metabolized through three major pathways, cyclooxygenase (COX), lipoxygenase (LO) and cytochrome P450, to ...
Joanna M Poczobutt +9 more
doaj +1 more source
Hepatology, EarlyView., 2022 Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog +12 more
wiley +1 more source