Results 41 to 50 of about 5,706 (150)
Molecules, 2020 Nonalcoholic fatty liver disease (NAFLD) is becoming a major public health problem worldwide. The study aimed to evaluate the concentration of eicosanoids in serum and liver tissue during steatosis progression and to assess whether eicosanoid change ...
Dominika Maciejewska +7 more
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Flux Sampling Suggests Metabolic Signatures of High Antibody‐Producing CHO Cells
Biotechnology and Bioengineering, EarlyView.ABSTRACT Chinese hamster ovary (CHO) cells remain the industry standard for producing numerous therapeutic proteins, particularly monoclonal antibodies (mAbs). However, achieving higher recombinant protein titers remains an ongoing challenge and a fundamental understanding of the cellular mechanism driving improved bioprocess performance remains ...
Kate E. Meeson +9 more
wiley +1 more source
Lipid Metabolism and Immune Function: Chemical Tools for Insights into T‐Cell Biology
ChemBioChem, EarlyView.This review explores how lipids regulate immune responses, particularly in T‐cell function. Advances in metabolomics and proteomics provide insights into lipid‐mediated immunity. Fluorescent lipids enable single‐cell analysis of lipid uptake and metabolism.
Luuk Reinalda +2 more
wiley +1 more source
Journal of Lipid Research, 2007 Human 15-lipoxygenase (LOX)-2 and mouse 8-LOX represent orthologous members of the LOX family but display different positional specificities and tissue distribution. To study the functional role of 15-LOX-2 and 8-LOX in keratinocytes, an inducible Tet-On
Dorothea Schweiger +2 more
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Eicosanoids: Atherosclerosis and cardiometabolic health
Journal of Clinical & Translational Endocrinology, 2020 Cardiovascular diseases (CVD) have been the leading causes of death in the U.S. for nearly a century. Numerous studies have linked eicosanoids to cardiometabolic disease.
Kimberly Piper, Mahdi Garelnabi
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Marine Drugs, 2019 The red macroalga Agarophyton chilensis is a well-known producer of eicosanoids such as hydroxyeicosatetraenoic acids, but the alga produces almost no prostaglandins, unlike the closely related A. vermiculophyllum.
Masaki Honda +3 more
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Expression and Function of Eicosanoid-Producing Cytochrome P450 Enzymes in Solid Tumors
Frontiers in Pharmacology, 2020 Oxylipins derived from the oxidation of polyunsaturated fatty acids (PUFAs) act as important paracrine and autocrine signaling molecules. A subclass of oxylipins, the eicosanoids, have a broad range of physiological outcomes in inflammation, the immune ...
Eric A. Evangelista +3 more
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Chemistry–Methods, EarlyView.A deep learning‐based method Siamese transformer reaction pair (STRP) prediction is presented for identifying important pathways in untargeted LC‐MS/MS metabolomics. STRP accurately predicts metabolic reaction pairs from known metabolites and tandem mass spectra of unannotated metabolic features, which enhance the utility of untargeted metabolomics ...
Han Bao +7 more
wiley +1 more source
Lipid and Corticosteroid Biomarkers Under the Influence of Bisphosphonates
Drug Testing and Analysis, EarlyView.The detection of bisphosphonates is important due to the potential integrity and welfare issues associated with use of these substances. Targeted detection of a nitrogenous and non‐nitrogenous bisphosphonate was detected for 8 h and 28 days post‐administration, respectively.
Kathy Tou +8 more
wiley +1 more source
Leukotriene B4 limits the effectiveness of fish oil in an animal model of asthma
Heliyon, 2021 This study aimed to evaluate the levels of eicosanoids derived from arachidonic acid (ARA) in the lungs of asthmatic rats supplemented with fish oil. The present data gives insight into the action of fish oil in asthma, related to its inability to modify
D.T.S.Z. Miranda +4 more
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