Results 61 to 70 of about 5,706 (150)

Longevity Humans Have Youthful Erythrocyte Function and Metabolic Signatures

Aging Cell, EarlyView.
Longevity humans have “a youthful erythrocyte function and metabolism” with a youth‐like oxygen release and anti‐oxidative capability to combat tissue hypoxia and improve healthspan. ABSTRACT Longevity individuals have lower susceptibility to chronic hypoxia, inflammation, oxidative stress, and aging‐related diseases.
Fang Yu, Changhan Chen, Wuping Liu, Zhixiang Zhao, Yuhua Fan, Zhenjiang Li, Weilun Huang, Tingting Xie, Cheng Luo, Zhouzhou Yao, Qi Guo, Zhiyu Yang, Juan Liu, Yujin Zhang, Rodney E. Kellems, Jian Xia, Ji Li, Yang Xia   +17 more
wiley   +1 more source

Protein succinylome analysis identifies citrate synthase as a central regulator of osteoclast metabolic activity

The FEBS Journal, EarlyView.
RANKL treatment induces expression of the aconitate decarboxylase (ACOD1) in differentiating osteoclasts, which increases succinate levels. The initially high expression of ACOD1 decreases towards the end of differentiation when the levels of the desuccinylase SIRT5 increase. Succinylation of citrate synthase (CS) was detected exclusively in stimulated
Dayoung Yu, Yue Gao, Marcin Luzarowski, Elisabeth Seebach, Thomas Heitkamp, Michael Börsch, Thomas Ruppert, Katharina F. Kubatzky   +7 more
wiley   +1 more source

n‐3 PUFAs docosahexaenoic acid and eicosapentaenoic acid are effective natural pro‐resolution ingredients for topical skin applications

International Journal of Cosmetic Science, EarlyView.
Skin encounters many challenges that lead to an inflammatory response. Resolution of this inflammation is needed to return the skin to a healthy state. A review of the role of topical n‐3 PUFAs, particularly DHA and EPA, in resolving skin inflammation and promoting skin health is presented.
John Nip, Kevin Hermanson, Jian‐ming Lee   +2 more
wiley   +1 more source

Thematic Review Series: Exosomes and Microvesicles: Lipids as Key Components of their Biogenesis and Functions Extracellular vesicles and their content in bioactive lipid mediators: more than a sack of microRNA

Journal of Lipid Research, 2018
Extracellular vesicles (EVs), such as exosomes and microvesicles, are small membrane-bound vesicles released by cells under various conditions. In a multitude of physiological and pathological conditions, EVs contribute to intercellular communication by ...
Eric Boilard
doaj  

Evaluation of the performance of ChatGPT‐4 and ChatGPT‐4o as a learning tool in endodontics

International Endodontic Journal, EarlyView.
Abstract Aims The aim of this study was to evaluate the accuracy and consistency of responses given by two different versions of Chat Generative Pre‐trained Transformer (ChatGPT), ChatGPT‐4, and ChatGPT‐4o, to multiple‐choice questions prepared from undergraduate endodontic education topics at different times of the day and on different days ...
Esra Arılı Öztürk, Ceren Turan Gökduman, Burhan Can Çanakçi   +2 more
wiley   +1 more source

Antagonizing Arachidonic Acid-Derived Eicosanoids Reduces Inflammatory Th17 and Th1 Cell-Mediated Inflammation and Colitis Severity

Mediators of Inflammation, 2014
During colitis, activation of two inflammatory T cell subsets, Th17 and Th1 cells, promotes ongoing intestinal inflammatory responses. n-6 polyunsaturated fatty acid- (PUFA-) derived eicosanoids, such as prostaglandin E2 (PGE2), promote Th17 cell ...
Jennifer M. Monk, Harmony F. Turk, Yang-Yi Fan, Evelyn Callaway, Brad Weeks, Peiying Yang, David N. McMurray, Robert S. Chapkin   +7 more
doaj   +1 more source

Role of CYP eicosanoids in the regulation of pharyngeal pumping and food uptake in Caenorhabditis elegans[S]

Journal of Lipid Research, 2015
Cytochrome P450 (CYP)-dependent eicosanoids comprise epoxy- and hydroxy-metabolites of long-chain PUFAs (LC-PUFAs). In mammals, CYP eicosanoids contribute to the regulation of cardiovascular and renal function. Caenorhabditis elegans produces a large set
Yiwen Zhou, John R. Falck, Michael Rothe, Wolf-Hagen Schunck, Ralph Menzel   +4 more
doaj  

Health Implications of High Dietary Omega-6 Polyunsaturated Fatty Acids

Journal of Nutrition and Metabolism, 2012
Omega-6 (n-6) polyunsaturated fatty acids (PUFA) (e.g., arachidonic acid (AA)) and omega-3 (n-3) PUFA (e.g., eicosapentaenoic acid (EPA)) are precursors to potent lipid mediator signalling molecules, termed “eicosanoids,” which have important roles in ...
E. Patterson, R. Wall, G. F. Fitzgerald, R. P. Ross, C. Stanton   +4 more
doaj   +1 more source

Eicosanoid Profile of Influenza A Virus Infected Pigs

Metabolites, 2019
Respiratory tract infections caused by the Influenza A virus (IAV) are a worldwide problem for human and animal health. Within this study, we analyzed the impact of IAV infection on the immune-related lipidome (eicosanoids) of the pig as new infection ...
Daniel Schultz, Karen Methling, KoInfekt Study Group, Michael Rothe, Michael Lalk   +4 more
doaj   +1 more source

The gut‐microbiota‐brain axis: Focus on gut steroids

Journal of Neuroendocrinology, EarlyView.
Abstract There are over 1000 varieties of steroids that have been reported in nature, including the endogenous sex steroid hormones (i.e., progesterone, testosterone, and 17β‐estradiol) and corticosteroids which are mainly synthesized by gonads and adrenals, respectively.
Silvia Diviccaro, Silvia Giatti, Lucia Cioffi, Gabriela Chrostek, Roberto Cosimo Melcangi   +4 more
wiley   +1 more source