Results 81 to 90 of about 24,894 (189)

Insights Into the Biological Mechanisms and Multifunctional Health Benefits of Morelloflavone

open access: yeseFood, Volume 7, Issue 4, August 2026.
Morelloflavone (MF), a biflavonoid from Garcinia and related species, exhibits broad human health benefits through antioxidant, anti‐inflammatory, anticancer, and metabolic regulatory effects. This review highlights its molecular mechanisms, biosynthesis, and emerging roles in chronic disease prevention, emphasizing systems biology and machine learning
Yi Liu   +4 more
wiley   +1 more source

Time Dependent Production of Cytokines and Eicosanoids by Human Monocytic Leukaemia U937 Cells; Effects of Glucocorticosteroids

open access: yesMediators of Inflammation, 1999
In the present study the human monoblast cell line U937 has been used as a model to study the function of human mononuclear phagocytes in asthma. The kinetics of the production of eicosanoids and cytokines, which are thought to play a role in the ...
Ingrid M. Garrelds   +5 more
doaj   +1 more source

Effects of sodium humate and zinc oxide used in prophylaxis of post-weaning diarrhoea on the health, oxidative stress status and fatty acid profile in weaned piglets

open access: yesVeterinární Medicína, 2017
The aim of this study was to investigate the effects of sodium humate (HNa), applied to feed or drinking water as a partial substitution for pharmacological doses of ZnO, on clinical, biochemical and haematological indicators of health status, oxidative ...
M. Trckova   +4 more
doaj   +1 more source

Vitamin E‐Related Molecular Signatures in Adolescent Idiopathic Scoliosis: A Hypothesis‐Generating Multi‐Omics Analysis

open access: yesFood Science &Nutrition, Volume 14, Issue 8, August 2026.
Integrative analysis of plasma miRNA data (GSE235203) and BM‐MSC transcriptomic data (GSE110359), combined with database‐derived VE/tocopherol target mapping, prioritized SOD1, GCLC, PTGS1, PTGS2, and KDR. Single‐cell localization, CellChat analysis, structural simulation, NHANES contextualization, and GSE286204 supported hypothesis‐generating links to
Ying Ma   +8 more
wiley   +1 more source

Cytochrome P450-derived epoxyeicosatrienoic acids and coronary artery disease in humans: a targeted metabolomics study

open access: yesJournal of Lipid Research, 2016
Cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) exhibit potent cardiovascular protective effects in preclinical models, and promoting the effects of EETs has emerged as a potential therapeutic strategy for coronary artery disease (CAD ...
Akinyemi Oni-Orisan   +12 more
doaj   +1 more source

The Role of Immunoresolvents in Atherosclerosis: A Mini‐Review on Their Biology and Therapeutic Opportunities

open access: yesHealth Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aims Atherosclerosis is a lipid‐induced chronic inflammatory cardiovascular disorder denoted by the infiltration of immune cells and the agglomeration of lipids in the intima, the innermost layer, of the arteries of large and medium sizes.
Ramin Lotfi   +4 more
wiley   +1 more source

Role of omega-3 unsaturated acids in prevention and treatment of different diseases (part 1)

open access: yesЛечащий Врач, 2021
Currently, one of the most discussed issue in medicine is importance of omega-3 fatty acids for human body. There are several types of omega fatty acids: omega-9, omega-6 and omega-3 polyunsaturated lipids.
E. Yu. Plotnikova   +2 more
doaj  

Myocardial Lipid Metabolism Imbalance: The Pathological Core and Novel Diagnostic‐Therapeutic Directions of Cardiovascular Diseases

open access: yesJournal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
In cardiac cells, Plin5/AMPK regulate lipid homeostasis; excess CD36‐mediated uptake drives lipotoxicity, mitochondrial dysfunction, and CVDs (e.g., heart failure). Biomarkers (ApoB/ApoA‐1) and therapies (SGLT2 inhibitors) target this cascade. ABSTRACT Cardiac lipid metabolism is fundamental to myocardial energy homeostasis, with fatty acid oxidation ...
Peiyun Xie   +3 more
wiley   +1 more source

Early and Divergent Lipid Mediator Remodelling in Fast Versus Slow Skeletal Muscles of Female hSOD1G93A Mice

open access: yesJournal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Skeletal muscle atrophy in amyotrophic lateral sclerosis (ALS) drives loss of muscle strength, function and quality of life in ALS patients. The endocannabinoid system (ECS) regulates muscle homeostasis via regenerative and metabolic processes, and although ECS alterations have been reported in ALS neural tissues, ECS remodelling ...
Sebastiaan Dalle   +7 more
wiley   +1 more source

A PLA2 deletion mutant using CRISPR/Cas9 coupled to RNASeq reveals insect immune genes associated with eicosanoid signaling.

open access: yesPLoS ONE
Eicosanoids mediate insect immune responses and synthesized by the catalytic activity of phospholipase A2 (PLA2). A uniquely encoded secretory PLA2 (sPLA2) is associated with immune responses of a lepidopteran insect, Spodoptera exigua.
Mohammad Vatanparast   +3 more
doaj   +1 more source

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