Results 101 to 110 of about 31,692 (187)

Efficacy of Biologics in Aspirin Exacerbated Respiratory Disease

Clinical and Translational Allergy, Volume 16, Issue 10, October 2026.
ABSTRACT Background Aspirin‐exacerbated respiratory disease (AERD), also termed nonsteroidal anti‐inflammatory drug exacerbated respiratory disease (NERD), is characterized by asthma, chronic rhinosinusitis with nasal polyposis, and hypersensitivity to cyclooxygenase‐1 inhibitors, frequently resulting in severe, treatment‐refractory airway disease ...
Jennifer K. Priessnitz, Anastasia Hagopian, Alison J. Patev, Joseph K. Han, Kent K. Lam   +4 more
wiley   +1 more source

Cytochrome P450 Eicosanoids are Activators of Peroxisome Proliferator-Activated Receptor ␣ [PDF]

, 2020
: Cytochrome P450 (P450) eicosanoids regulate vascular tone, renal tubular transport, cellular proliferation, and inflammation. Both the CYP4A -hydroxylases, which catalyze 20-hydroxyeicosatetraenoic acid (20-HETE) formation, and soluble epoxide ...

core  

PGE2 Enhances Human ILC3 Function but Constrains ILC2‐to‐ILC3 Plasticity

European Journal of Immunology, Volume 56, Issue 10, October 2026.
Distinct prostaglandin circuits regulate human ILC2 and ILC3 function. ILC3‐derived PGE2 promotes type 3 cytokine production, whereas hybrid ILC2/3 generated during plasticity retain an inhibitory response to PGE2 despite acquiring ILC3‐like features. ABSTRACT Type 2 innate lymphoid cells (ILC2) drive eosinophilic asthma, whereas ILC3 and plastic ILC2 ...
Lorenz Wirth, Whitney Weigel, Efthymia Kokkinou, Johan Kolmert, Anna‐Karin Johnsson, Alessandro Quaranta, Craig Wheelock, Mattias Jangard, Ram V. Pandey, Sven‐Erik Dahlén, Christopher Andrew Tibbitt, Thomas Hochdörfer, Jenny Mjösberg   +12 more
wiley   +1 more source

Inhibition of Soluble Epoxide Hydrolase Reduces Inflammation and Myocardial Injury in Arrhythmogenic Cardiomyopathy

JACC: Basic to Translational Science
Summary: We analyzed the role of pro- and anti-inflammatory eicosanoids in the pathogenesis of arrhythmogenic cardiomyopathy (ACM). Lipidomics revealed reduced levels of anti-inflammatory oxylipins in plasma and increased levels of pro-inflammatory ...
Dipak Panigrahy, MD, Abigail G. Kelly, BA, Katherine M. Quinlivan, BS, Weicang Wang, PhD, Jun Yang, PhD, Sung Hee Hwang, PhD, Michael Gillespie, BA, Isabella V. Howard, Carlos Bueno-Beti, PhD, Angeliki Asimaki, PhD, Vinay Penna, BA, Kory Lavine, MD, PhD, Matthew L. Edin, PhD, Darryl C. Zeldin, MD, Bruce D. Hammock, PhD, Jeffrey E. Saffitz, MD, PhD   +15 more
doaj   +1 more source

Crosstalk Between Parkinson's Disease and Colorectal Cancer: Genetic Mechanisms, Gut Microbiota, and Therapeutic Insights

Health Care Science, Volume 5, Issue 5, Page 495-513, October 2026.
This review elucidates the crosstalk between Parkinson's disease and colorectal cancer, driven by shared genetics (PRKN, PINK1, DJ‐1) involving oxidative stress, cell cycle regulation, and inflammation. It identifies the gut microbiota—via functional amyloids and short‐chain fatty acids (SCFAs)—as a mechanistic bridge, offering insights for dual ...
Jiacheng Ying, Zhengyuan Fang, Cheng Zhang, Xu Liu, Jianzhi Cui, Zezhi Li, Jiayin Tang   +6 more
wiley   +1 more source

Editorial: Eicosanoids in Cancer

Frontiers in Pharmacology, 2021
Nune Markosyan, Emer M. Smyth, Paola Patrignani, Emanuela Ricciotti   +3 more
doaj   +1 more source

NOD2-Mediated Innate Immune Signaling Regulates the Eicosanoids in Atherosclerosis

, 2013
Objective-The activity of eicosanoid pathways is critical to the inflammatory and immune responses that are associated with the progression of atherosclerosis. Yet, the signals that regulate these pathways are poorly understood.
Nijhuis, Manon Oude, Yan, ZQ, Pasterkamp, G, Jakobsson, PJ, Idborg, H, Edfeldt, K, Nijhuis, MO, Zhang, Xiao-Ying, Idborg, Helena, Yan, Zhong-Qun, Roy, J, Hedin, U, Hansson, GK, Back, Magnus, Edfeldt, Kristina, Roy, Joy, Pasterkamp, Gerard, de Kleijn, DP, Hedin, Ulf, Jakobsson, Per-Johan, Hansson, Goran K., Back, M, Laman, Jon, Laman, Jon D., Zhang, XY, Liu, Hui-Qing, de Kleijn, Dominique P., Liu, HQ   +27 more
core   +1 more source

Exploring the Impact of Urolithins A and B on Muscle Health: A Transcriptomic Analysis in Human Myotubes

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Background Urolithin A (UA) and urolithin B (UB) are gut microbiota‐derived metabolites of ellagitannins reported to influence mitochondrial function, inflammation and muscle metabolism. Their comparative transcriptomic effects in human skeletal muscle cells remain undefined.
Yves Henrotin, Antoine Florin, Christelle Sanchez, Prescilia Centonze, Tiago Pinto Coelho, Sophie Bekisz, Jean‐Emile Dubuc, Olivier Galand, Cécile Lambert   +8 more
wiley   +1 more source

The calcineurin–NFATc pathway modulates the lipid mediators in BAL fluid extracellular vesicles, thereby regulating microvascular endothelial cell barrier function

Frontiers in Physiology
Extracellular vesicles mediate intercellular communication by transporting biologically active macromolecules. Our prior studies have demonstrated that the nuclear factor of activated T cell cytoplasmic member 3 (NFATc3) is activated in mouse pulmonary ...
Manjula Karpurapu, Yunjuan Nie, Sangwoon Chung, Jiasheng Yan, Patrick Dougherty, Sonal Pannu, Jon Wisler, Ryan Harkless, Narasimham Parinandi, Evgeny Berdyshev, Dehua Pei, John W. Christman   +11 more
doaj   +1 more source

Cytochrome P450 eicosanoids and cerebral vascular function

, 2011
The eicosanoids 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs), which are generated from the metabolism of arachidonic acid by cytochrome P450 (CYP) enzymes, possess a wide array of biological actions, including the ...
John D. Imig, Marija Renic, Alexis N. Simpkins, David R. Harder   +3 more
core   +1 more source