Results 91 to 100 of about 24,894 (189)

Amino Acid and Lipid Metabolism in Cancer: Mechanisms and Therapeutic Opportunities

MedComm, Volume 7, Issue 8, August 2026.
Amino Acid and lipid metabolism in cancer: (A) Regulation of Amino acid transportation and metabolism in cancer. (B) The core organization of lipid metabolic reprogramming in cancer and their functional consequences. ABSTRACT Metabolic reprogramming is a defining feature of cancer and a major contributor to immune escape.
Zixu Wang, Xin Fu, Jingchao Bai, Yanguo Liu, Kai Huang   +4 more
wiley   +1 more source

The Dietary Protein Source Modulates Obesity Development and Induces Distinct Plasma Lipid Profiles and Transcriptome Profiles in Liver and Adipose Tissue

Molecular Nutrition &Food Research, Volume 70, Issue 15, 17 August 2026.
By performing plasma metabolomics analyses combined with RNA sequencing and gene set enrichment analyses of liver, muscle, white‐ and brown‐adipose tissue in mice, we aimed to decipher the metabolic output and pathways modulated by intake of different dietary proteins.
Lene S. Myrmel, Even Fjære, Annette Bernhard, Josef D. Rasinger, Ole Jakob Nøstbakken, Helene Søiland, Philipp Rausch, Martin von Bergen, Ulrike Rolle‐Kampzcyk, Liang Xiao, Hanlin Zhou, Guibo Li, Karsten Kristiansen, Lise Madsen   +13 more
wiley   +1 more source

Role of Polyunsaturated Fatty Acids (PUFAs) and Eicosanoids on Dry Eye Symptoms and Signs

Biomolecules
Polyunsaturated fatty acids (PUFAs) generate pro- and anti-inflammatory eicosanoids via three different metabolic pathways. This study profiled tear PUFAs and their metabolites and examined the relationships with dry eye (DE) and meibomian gland ...
Simran Mangwani-Mordani, Amanda Prislovsky, Daniel Stephenson, Charles E. Chalfant, Anat Galor, Nawajes Mandal   +5 more
doaj   +1 more source

Opposing roles of DGAT‐mediated lipid droplet biogenesis in the regulation of ferroptosis sensitivity

The FEBS Journal, Volume 293, Issue 15, Page 4508-4532, August 2026.
Ferroptosis is driven by unrestricted peroxidation of polyunsaturated fatty acyl (PUFA) chains in membrane phospholipids. In triple‐negative breast cancer cells, lipid droplets (LDs) sequester dietary PUFAs, limiting their incorporation into membrane phospholipids, preventing mitochondrial damage, and reducing lipid peroxidation and ferroptosis.
Ana Kump, Leja Perne, Špela Koren, Eva Jarc Jovičić, Nastja Feguš, Carina Pinto Kozmus, Michele Wölk, Kristyna Brejchova, Maria Fedorova, Ondrej Kuda, Toni Petan   +10 more
wiley   +1 more source

Steroidogenic compensation and lipid deficiency with enhanced NAD+ salvage in small‐for‐gestational‐age placenta

The FEBS Journal, Volume 293, Issue 15, Page 4554-4577, August 2026.
Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo, Lorenza Driul, Vanessa Tolotto, Eros Di Giorgio, Luigi E. Xodo   +4 more
wiley   +1 more source

Inhibition of Soluble Epoxide Hydrolase Reduces Inflammation and Myocardial Injury in Arrhythmogenic Cardiomyopathy

JACC: Basic to Translational Science
Summary: We analyzed the role of pro- and anti-inflammatory eicosanoids in the pathogenesis of arrhythmogenic cardiomyopathy (ACM). Lipidomics revealed reduced levels of anti-inflammatory oxylipins in plasma and increased levels of pro-inflammatory ...
Dipak Panigrahy, MD, Abigail G. Kelly, BA, Katherine M. Quinlivan, BS, Weicang Wang, PhD, Jun Yang, PhD, Sung Hee Hwang, PhD, Michael Gillespie, BA, Isabella V. Howard, Carlos Bueno-Beti, PhD, Angeliki Asimaki, PhD, Vinay Penna, BA, Kory Lavine, MD, PhD, Matthew L. Edin, PhD, Darryl C. Zeldin, MD, Bruce D. Hammock, PhD, Jeffrey E. Saffitz, MD, PhD   +15 more
doaj   +1 more source

eicosanoids

, 2019
Citation: 'eicosanoids' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.E01912 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Editorial: Eicosanoids in Cancer

Frontiers in Pharmacology, 2021
Nune Markosyan, Emer M. Smyth, Paola Patrignani, Emanuela Ricciotti   +3 more
doaj   +1 more source

The calcineurin–NFATc pathway modulates the lipid mediators in BAL fluid extracellular vesicles, thereby regulating microvascular endothelial cell barrier function

Frontiers in Physiology
Extracellular vesicles mediate intercellular communication by transporting biologically active macromolecules. Our prior studies have demonstrated that the nuclear factor of activated T cell cytoplasmic member 3 (NFATc3) is activated in mouse pulmonary ...
Manjula Karpurapu, Yunjuan Nie, Sangwoon Chung, Jiasheng Yan, Patrick Dougherty, Sonal Pannu, Jon Wisler, Ryan Harkless, Narasimham Parinandi, Evgeny Berdyshev, Dehua Pei, John W. Christman   +11 more
doaj   +1 more source

Gut microbiota in chronic inflammation: the interplay with lipid mediators. [PDF]

Gut Microbes
Bao S, Yao C.
europepmc   +1 more source