Results 91 to 100 of about 31,692 (187)

Inhibition of the MALT1-LPCAT3 axis protects cartilage degeneration and osteoarthritis

Cell Communication and Signaling
The proinflammatory cytokines and arachidonic acid (AA)-derived eicosanoids play a key role in cartilage degeneration in osteoarthritis (OA). The lysophosphatidylcholine acyltransferase 3 (LPCAT3) preferentially incorporates AA into the membranes.
Vijay Kondreddy, Rajkumar Banerjee, B. L. A. Prabhavathi Devi, Kathirvel Muralidharan, Selvakumar Piramanayagam   +4 more
doaj   +1 more source

Role of omega-3 unsaturated acids in prevention and treatment of different diseases (part 1)

Лечащий Врач, 2021
Currently, one of the most discussed issue in medicine is importance of omega-3 fatty acids for human body. There are several types of omega fatty acids: omega-9, omega-6 and omega-3 polyunsaturated lipids.
E. Yu. Plotnikova, M. N. Sinkova, L. K. Isakov   +2 more
doaj  

Systemic Lipid Peroxidation and Colorectal Cancer Risk: A Time‐Varying Relationship

International Journal of Cancer, Volume 159, Issue 9, Page 2170-2183, 1 November 2026.
Experimental studies in animals suggest that oxidative stress (OxS) declines as cancer progresses. Whether this occurs in humans, however, remains unclear. The authors of the present study addressed this question by analyzing lipid, DNA, and RNA oxidation biomarkers in relation to colorectal cancer (CRC) risk in patients from Shanghai and the United ...
Gong Yang, Ginger L. Milne, Marina S. Nogueira, Yu‐Tang Gao, Qing Lan, Haoyang Yi, Xiao‐Ou Shu, Wei Zheng, Qingxia Chen   +8 more
wiley   +1 more source

4‐Octyl Itaconate Attenuates Age‐Induced Parotid Gland Dysfunction Through the Suppression of Fibrosis and Lipid Deposition by AMPKα/PPARα and the Inhibition of Oxidative Stress via the AMPKα/Nrf2 Signaling Pathway

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
4‐Octyl itaconate (4‐OI) attenuates age‐induced parotid gland dysfunction through the suppression of fibrosis and lipid deposition by AMPKα/PPARα and the inhibition of oxidative stress via the AMPKα/Nrf2 signaling pathway. 4‐OI activates AMPKα, which in turn stimulates both the PPARα and Nrf2 pathways. Activation of PPARα enhances FAO and reduces lipid
Yun Chen, Tianyuan Gong, Zhongyan Shan, Jing Lai, Yiming Xu, Han Zhao, Lilei Zhu   +6 more
wiley   +1 more source

Dodonaea viscosa in Breast Cancer: Phytochemistry, Anticancer Mechanisms, and Emerging Immunotherapeutic and Translational Perspectives

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Breast cancer remains a leading cause of cancer‐related mortality among women worldwide, with treatment resistance, disease heterogeneity, and therapy‐associated toxicities limiting clinical outcomes. Its major clinically relevant subtypes, including oestrogen receptor‐positive (ER+), human epidermal growth factor receptor 2‐positive (HER2 ...
Nireshini Reddy, Catherine H. Kaschula, Nokwanda P. Makunga, Willem Jacobus Perold, Sanjeev Rambharose, Anna‐Mart Engelbrecht   +5 more
wiley   +1 more source

A PLA2 deletion mutant using CRISPR/Cas9 coupled to RNASeq reveals insect immune genes associated with eicosanoid signaling.

PLoS ONE
Eicosanoids mediate insect immune responses and synthesized by the catalytic activity of phospholipase A2 (PLA2). A uniquely encoded secretory PLA2 (sPLA2) is associated with immune responses of a lepidopteran insect, Spodoptera exigua.
Mohammad Vatanparast, Mojtaba Esmaeily, David Stanley, Yonggyun Kim   +3 more
doaj   +1 more source

Optimized scheduled MRM pairs and parameters for eicosanoids.

, 2016
Optimized scheduled MRM pairs and parameters for eicosanoids.
D. Kvaskoff (2141107), G. E. Rice (2141116), K. Vaswani (2141113), M. D. Mitchell (2141104), H. N. Peiris (2141110)   +4 more
core   +1 more source

Synergistic Phytochemicals From Mitracarpus frigidus (Willd. ex Roem. & Schult.) K. Schum. and Lantana camara Linn. in Chitosan Biofilms: Antioxidant and Anti‐Inflammatory Activities With Wound‐Healing Potential

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Biodegradable chitosan films loaded with a 1:1 combination of Mitracarpus frigidus and Lantana camara extracts demonstrated potent antioxidant, anti‐inflammatory, and wound‐healing properties, while exhibiting low cytotoxicity and favorable physicochemical characteristics.
Natasha Silva Mayrink, Julia Bertolini Fajardo, Mariane Rocha Cordeiro Comitre, Lucas de Araújo Carvalho, Mariana Iasbeck Dalcol, Priscila de Lima Paula, Lara Melo Campos, Maria Clara Machado Resende Guedes, Luiz Fernando Cappa de Oliveira, Elaine Soares Coimbra, Gilson Costa Macedo, Ângelo Márcio Leite Denadai, Ari Sérgio de Oliveira Lemos, Rodrigo Luiz Fabri   +13 more
wiley   +1 more source

Role of Polyunsaturated Fatty Acids (PUFAs) and Eicosanoids on Dry Eye Symptoms and Signs

Biomolecules
Polyunsaturated fatty acids (PUFAs) generate pro- and anti-inflammatory eicosanoids via three different metabolic pathways. This study profiled tear PUFAs and their metabolites and examined the relationships with dry eye (DE) and meibomian gland ...
Simran Mangwani-Mordani, Amanda Prislovsky, Daniel Stephenson, Charles E. Chalfant, Anat Galor, Nawajes Mandal   +5 more
doaj   +1 more source

Capybara Oil‐Based Nanoemulsion Attenuates Obesity‐Induced Renal Injury Through Modulation of Inflammation, Oxidative Stress, and Fibrosis in Mice

Cell Biochemistry and Function, Volume 44, Issue 10, October 2026.
ABSTRACT Obesity is a multifactorial disorder associated with systemic metabolic alterations and increased risk of renal injury, largely driven by chronic inflammation and oxidative stress. Bioactive lipids, particularly polyunsaturated fatty acids, have been shown to exert protective effects; however, their instability and susceptibility to oxidation ...
Priscila G. Pereira, Luciana L. Alves, Bianca T. Ciambarella, Stela R. Ferrarini, Ana Lúcia R. Nascimento, Cherley B. V. Andrade, Alan Cesar N. Moraes, Andressa Bernardi, Fernanda V. Guimarães, Miguel P. Campos, Denia M. S. Valladão, Letícia Cruz, Jemima F. R. da Silva, Kíssila Rabelo, Jorge J. de Carvalho   +14 more
wiley   +1 more source