Results 71 to 80 of about 31,692 (187)
Allergy, EarlyView.ABSTRACT Basophils, the least abundant leukocytes, are increasingly recognised as potent immunomodulators. Upon activation, they rapidly release preformed granule‐associated mediators including histamine and lipid mediators such as LTC4, while cytokine production occurs over a longer timescale, contributing to downstream immune responses.
Jitesh Chauhan +5 more
wiley +1 more source
Nomenclature on Immune‐Mediated Drug Reactions: An EAACI Position Paper
Allergy, EarlyView.ABSTRACT Over the past several decades, there have been significant advances in our understanding of both immunological and pharmacological mechanisms of adverse drug reactions (ADRs). Immune‐mediated drug reactions (IMDRs) represent a small proportion of ADRs and are caused by a pathological activation of the immune system or inflammatory pathways ...
Maria J. Torres +19 more
wiley +1 more source
Multiple eicosanoids are increased in tumor bearing mice.
, 2013 LLC-Luc cells or matrigel (control) were injected into left lung lobes of WT C57Bl/6 mice and tumor-bearing and control lungs were harvested 2 or 3 weeks after injection.
Dwight Hanson (482165) +9 more
core +1 more source
EPHX2 Loss Promotes CRC Migration via EET‐Dependent Chemokine Elevation and Mitochondrial Defect
Cancer Science, EarlyView.Loss of EPHX2 promotes EET accumulation, which in turn enhances CXCL and ROS production, thereby promoting the migratory and invasive abilities of CRC cells. ABSTRACT Epoxide hydrolase 2 (EPHX2) is a key enzyme in fatty acid metabolism that metabolizes epoxyeicosatrienoic acids (EETs), lipid mediators involved in inflammation, angiogenesis, and ...
Jianjun Zhu +10 more
wiley +1 more source
Eicosanoids and Eosinophilic Inflammation of Airways in Stable COPD
International Journal of COPD, 2021 Natalia Celejewska-Wójcik,1 Aleksander Kania,1 Karolina Górka,1 Paweł Nastałek,1 Krzysztof Wójcik,2 Anna Gielicz,3 Lucyna Mastalerz,1 Marek Sanak,3 Krzysztof Sładek1 1Department of Pulmonology, 2nd Department of Internal Medicine ...
Celejewska-Wójcik N +8 more
doaj
Insects, 2019 Eicosanoids are bioactive signaling lipids derived from the oxidation of fatty acids that act as important regulators of immune homeostasis and inflammation.
Hyeogsun Kwon, Ryan C. Smith
doaj +1 more source
Role of eicosanoids on intestinal epithelial homeostasis [PDF]
, 2010 International audienceThe intestinal epithelium is a highly dynamic system that is continuously renewed by a process involving cell proliferation and differentiation.
Juan J. Moreno +3 more
core +1 more source
The FEBS Journal, EarlyView.Using 1H NMR metabolomics, we measured polar and lipid metabolites from human blood neutrophils from people with frailty (n = 31, mean age 84Y), people with rheumatoid arthritis (n = 16, mean age 55Y), robust older (n = 24, mean age 66Y) and healthy younger people (n = 21, mean age 22Y).
Genna Ali Abdullah +5 more
wiley +1 more source
Mediators of Inflammation, 2014 During colitis, activation of two inflammatory T cell subsets, Th17 and Th1 cells, promotes ongoing intestinal inflammatory responses. n-6 polyunsaturated fatty acid- (PUFA-) derived eicosanoids, such as prostaglandin E2 (PGE2), promote Th17 cell ...
Jennifer M. Monk +7 more
doaj +1 more source
Journal of Fish Biology, EarlyView.Abstract High‐latitude ecosystems are simultaneously warming and acidifying under ongoing climate change. Arctic cod (Boreogadus saida) are a key species in the Arctic Ocean and have demonstrated sensitivity to ocean warming and acidification as adults and embryos, but their larval sensitivity to the combined stressors is unknown. In a laboratory multi‐
Emily Slesinger +6 more
wiley +1 more source