Results 151 to 160 of about 71,664 (294)

Emerging Therapeutic Strategies for Hearing Loss

open access: yesAdvanced Therapeutics, Volume 8, Issue 7, July 2025.
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han   +9 more
wiley   +1 more source

Determinants of restenosis and lack of effect of dietary supplementation with eicosapentaenoic acid on the incidence of coronary artery restenosis after angioplasty

open access: bronze, 1989
Leeanne Grigg   +9 more
openalex   +1 more source

Altering 15‐Lipoxygenases to 18‐Lipoxygenases and Their Application to the Production of 5,18‐Dihydroxyeicosapentaenoic Acids

open access: yesBiotechnology and Bioengineering, Volume 122, Issue 7, Page 1759-1769, July 2025.
15R‐ and 15S‐lipoxygenases (15R‐ and 15S‐LOXs) were engineered into 18R‐ and 18S‐LOXs, respectively. Escherichia coli expressing these enzymes converted eicosapentaenoic acid into 18R‐ and 18S‐hydroxyeicosapentaenoic acids (18R‐ and 18S‐HEPEs), respectively.
Jin Lee   +3 more
wiley   +1 more source

Eicosapentaenoic Acid and 12-Lipoxygenase Pathway in Human Platelets

open access: bronze, 1985
Mitsuko Takenaga   +5 more
openalex   +2 more sources

Efficient One‐Step Production of 7S,17S‐ and 10S,17S‐Dihydroxydocosahexaenoic Acids by a Double‐Oxygenating 15S‐Lipoxygenase From Chlamydomonas incerta

open access: yesBiotechnology and Bioengineering, Volume 122, Issue 7, Page 1747-1758, July 2025.
Biotransformation pathway from polyunsaturated fatty acids into dihydroxy fatty acids as lipid mediators by Escherichia coli expressing Chlamydomonas incerta 15S‐lipoxygenase with double oxygenating activity. The 15S‐lipoxygenase was the most efficient for the simultaneous production of resolvin D5 (7S,17S‐dihydroxydocosahexaenoic acid, 7S,17S‐DiHDHA ...
Hyun‐Ah Park, Jin Lee, Deok‐Kun Oh
wiley   +1 more source

Binding modes of the metabolites docosahexaenoic acid, eicosapentaenoic acid, and eicosapentaenoic acid ethyl ester from Caulerpa racemosa as COX-2 inhibitors revealed via metabolomics and molecular dynamics

open access: yesInformatics in Medicine Unlocked
A total of 116 metabolites of Caulerpa racemosa were identified. However, only three (DHA, EPA, and EPAS) were found to have high anti-inflammatory potential, with Pa scores ranging from 0.764 to 0,827.
Turmidzi Fath   +5 more
doaj  

The effects of the unsaturated degree of long-chain fatty acids on the rumen microbial protein content and the activities of transaminases and dehydrogenase in vitro

open access: yesJournal of Integrative Agriculture, 2016
: This study investigated the effects of the degree of unsaturation (unsaturity) of long-chain fatty acids on microbial protein content and the activities of transaminases and dehydrogenase in vitro using goat rumen fluid as the cultural medium.
Jian GAO   +4 more
doaj  

Eicosapentaenoic Acid (EPA) in Atheroscrelosis

open access: bronze, 1983
Masashi Sakai   +9 more
openalex   +2 more sources

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