Results 11 to 20 of about 5,186,673 (318)

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Eicosapentaenoic Acid

Definitions, 2020
An essential, polyunsaturated, 20-carbon omega-3 fatty acid with anti-inflammatory and potential antineoplastic and chemopreventive activities. Eicosapentaenoic acid (EPA) may activate caspase 3, resulting in apoptosis in susceptible tumor cell ...

semanticscholar   +1 more source

Discovery of Eicosapentaenoic Acid Esters of Hydroxy Fatty Acids as Potent Nrf2 Activators

Antioxidants, 2020
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are a recently discovered class of biologically active lipids with anti-inflammatory and anti-diabetic properties.
S. G. B. Gowda, H. Fuda, Takayuki Tsukui, H. Chiba, S. Hui   +4 more
semanticscholar   +1 more source

Differential effects of eicosapentaenoic acid and oleic acid on lipid synthesis and secretion by HepG2 cells.

Journal of Lipid Research, 1991
The effects of eicosapentaenoic acid and oleic acid on lipid synthesis and secretion by HepG2 cells were examined to identify fatty acid specific changes in lipid metabolism that might indicate a basis for the hypolipidemic effect attributed to ...
R Homan, JE Grossman, HJ Pownall
doaj   +1 more source

A New E-Series Resolvin: RvE4 Stereochemistry and Function in Efferocytosis of Inflammation-Resolution

Frontiers in Immunology, 2021
The resolution of the acute inflammatory response is governed by phagocytes actively clearing apoptotic cells and pathogens. Biosynthesis of the specialized pro-resolving mediators (SPMs) is pivotal in the resolution of inflammation via their roles in ...
Stephania Libreros, Ashley E. Shay, Robert Nshimiyimana, David Fichtner, Michael J. Martin, Nicholas Wourms, Charles N. Serhan   +6 more
doaj   +1 more source

Diurnal rhythm of plasma EPA and DHA in healthy adults [PDF]

, 2020
Knowledge of the diurnal variation in circulating omega-3 polyunsaturated fatty acids (n-3 PUFAs) may be an important consideration for the development of dosing protocols designed to optimise tissue delivery of these fatty acids.
Avery, Hannah, Calder, Philip C., Forster, Joanne, Husberg, Cathrine, Hustvedt, Svein-Olaf, Jackson, Philippa, Kennedy, David, Khan, Julie   +7 more
core   +2 more sources

Effect of EPA and Vitamin C on Superoxide Dismutase, Glutathione Peroxidase, Total Antioxidant Capacity and Malondialdehyde in Type 2 Diabetic Patients

Oman Medical Journal, 2014
Objectives: The aim of this study is to investigate the effect of eicosapentaenoic acid combined with vitamin C in comparison with the pure form of eicosapentaenoic acid on the serum concentration of malondialdehyde, erythrocyte activity of superoxide ...
Mohammad Mehdi Shakouri Mahmoudabadi, Ali Reza Rahbar   +1 more
doaj   +1 more source

Dietary N-3 polyunsaturated fatty acids decrease biliary cholesterol saturation in gallstone disease [PDF]

, 1992
Because fatty acid composition of biliary phospholipids influences cholesterol secretion into bile, we investigated whether replacement of n-1 monounsaturated or n-6 polyunsaturated fatty acids with n-3 polyunsaturated fatty acids in biliary ...
Abell, Ahlberg, Balasubramaniam, Barlett, Bernd Seifferth, Berr, Berr, Berr, Berr, Carey, Carey, Carulli, Cohen, Cohen, Coleman, Dam, Delchier, Dieter Jüngst, Everson, Frieder Berr, Glenn, Goodnight, Gustav Paumgartner, Harris, Hofmann, Holan, Holzbach, Joseph Holl, Juniper, Kaludzny, Kelly, Kuroki, Leaf, Lee, Lippel, Lorenz, Magnuson, Marks, Nestel, Nestel, O'Leary, Parhofer, Paul, Phillipson, Pomeranz, Ramond, Robins, Robins, Sanders, Scobey, Sedaghat, Snedecor, Strasberg, Sven Fischer, Sömjen, Ventura, von Schacky, Wagner, Wechsler, Werner O. Richter   +59 more
core   +1 more source

Effects of Eicosapentaenoic Acid during In Vitro Maturation of Porcine Oocytes: Hormone Synthesis and Embryonic Developmental Potential

Journal of Animal Reproduction and Biotechnology, 2019
Among fatty acid families, the polyunsaturated fatty acids were demonstrated to be mediators in various reproductive processes as precursor of steroid hormone (via cholesterol) and prostaglandins (via arachidonic acid), and in the last decade, major ...
Kang-Sig Kim, Hum-Dai Park
doaj   +1 more source

Role of EPA in Inflammation: Mechanisms, Effects, and Clinical Relevance

Biomolecules, 2022
Many chronic inflammatory processes are linked with the continuous release of inflammatory mediators and the activation of harmful signal-transduction pathways that are able to facilitate disease progression.
Rosalia Crupi, Salvatore Cuzzocrea
doaj   +1 more source