Distinct regulatory networks control toxin gene expression in elapid and viperid snakes. [PDF]
BMC GenomicsBackground Venom systems are ideal models to study genetic regulatory mechanisms that underpin evolutionary novelty. Snake venom glands are thought to share a common origin, but there are major distinctions between venom toxins from the medically ...
Modahl CM +8 more
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Rapid Radiations and the Race to Redundancy: An Investigation of the Evolution of Australian Elapid Snake Venoms [PDF]
Toxins, 2016 Australia is the stronghold of the front-fanged venomous snake family Elapidae. The Australasian elapid snake radiation, which includes approximately 100 terrestrial species in Australia, as well as Melanesian species and all the world's true sea snakes,
Timothy N. W. Jackson +16 more
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The evolution of scale sensilla in the transition from land to sea in elapid snakes [PDF]
Open Biology, 2016 Scale sensilla are small tactile mechanosensory organs located on the head scales of many squamate reptiles (lizards and snakes). In sea snakes and sea kraits (Elapidae: Hydrophiinae), these scale organs are presumptive scale sensilla that purportedly ...
Jenna M. Crowe-Riddell +5 more
doaj +2 more sources
Differential Effects of Marimastat and Prinomastat on the Metalloprotease Activity of Various Snake Venoms. [PDF]
Toxins (Basel)Snakebite envenoming is a neglected tropical disease, responsible for approximately 140,000 deaths globally each year. Vipers and elapid snakes represent the most significant snake families in medical contexts, exhibiting a variety of venom components ...
Khatibi M +6 more
europepmc +2 more sources
Heterologous expression, protein folding and antibody recognition of a neurotoxin from the Mexican coral snake Micrurus laticorallis [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2016 Background The cysteine-rich neurotoxins from elapid venoms are primarily responsible for human and animal envenomation; however, their low concentration in the venom may hamper the production of efficient elapid antivenoms.
Herlinda Clement +5 more
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Venom Down Under: Dynamic Evolution of Australian Elapid Snake Toxins [PDF]
Toxins, 2013 Despite the unparalleled diversity of venomous snakes in Australia, research has concentrated on a handful of medically significant species and even of these very few toxins have been fully sequenced.
Timothy N. W. Jackson +9 more
doaj +2 more sources
Diversification rates and phenotypic evolution in venomous snakes (Elapidae) [PDF]
Royal Society Open Science, 2016 The relationship between rates of diversification and of body size change (a common proxy for phenotypic evolution) was investigated across Elapidae, the largest radiation of highly venomous snakes.
Michael S. Y. Lee +3 more
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An immunoinformatic approach to assessing the immunogenic capacity of alpha-neurotoxins in elapid snake venoms [PDF]
Frontiers in Pharmacology, 2023 Introduction: Most elapid snakes produce venoms that contain alpha-neurotoxins (α-NTXs), which are proteins that cause post-synaptic blockade and paralysis in snakebite envenoming.
Yi Wei Chan +3 more
doaj +2 more sources
Identification and Characterization of Novel Serpentoviruses in Viperid and Elapid Snakes. [PDF]
VirusesViruses in the subfamily Serpentovirinae (order Nidovirales, family Tobaniviridae) can cause significant morbidity and mortality in captive snakes, but documented infections have been limited to snakes of the Boidae, Colubridae, Homalopsidae, and ...
Tillis SB +11 more
europepmc +2 more sources
From Venom to Vein: Factor VII Activation as a Major Pathophysiological Target for Procoagulant Australian Elapid Snake Venoms. [PDF]
Toxins (Basel)Australian elapid snake venoms are uniquely procoagulant, utilizing blood clotting enzyme Factor Xa (FXa) as a toxin, which evolved as a basal trait in this clade.
Chandrasekara U +5 more
europepmc +2 more sources