Results 101 to 110 of about 1,869 (190)

Engineered nanoparticles bind elapid snake venom toxins and inhibit venom-induced dermonecrosis - Fig 3

, 2018
Nanoparticle binding to elapid snake venoms in concentrated human serum (A) Control experiments using the venom compositions of interest. (1) MW ladder. (1.1) Venom from Naja mossambica. (1.2) Venom from Bungarus caeruleus.
Shih-Hui Lee (1999681), Jeffrey O’Brien (1768237), Kenneth J. Shea (1306059), José María Gutiérrez (62868)   +3 more
core   +1 more source

Optimizing drug discovery for snakebite envenoming via a high-throughput phospholipase A2 screening platform

Frontiers in Pharmacology
Snakebite envenoming is a neglected tropical disease that causes as many as 1.8 million envenomings and 140,000 deaths annually. To address treatment limitations that exist with current antivenoms, the search for small molecule drug-based inhibitors that
Laura-Oana Albulescu, Laura-Oana Albulescu, Adam Westhorpe, Adam Westhorpe, Rachel H. Clare, Rachel H. Clare, Christopher M. Woodley, Nivya James, Jeroen Kool, Neil G. Berry, Paul M. O’Neill, Nicholas R. Casewell, Nicholas R. Casewell   +12 more
doaj   +1 more source

Nanotechnology-based paper microfluidics for rapid point-of-care detection and differentiation of snake venom types

Biosensors and Bioelectronics: X
Snake envenomation is recognized as a neglected tropical disease, contributing to high mortality rates and causing significant organ damage, particularly to the liver, kidneys, and brain.
Lakshmi Narashimhan Ramana, Nitin Salvi, M.V. Khadilkar, Tarun Kumar Sharma   +3 more
doaj   +1 more source

Standard Quality Characteristics and Efficacy of a New Third-Generation Antivenom Developed in Colombia Covering Micrurus spp. Venoms

Toxins
In Colombia, Micrurus snakebites are classified as severe according to the national clinical care guidelines and must be treated with specific antivenoms.
Santiago Tabares Vélez, Lina María Preciado, Leidy Johana Vargas Muñoz, Carlos Alberto Madrid Bracamonte, Angelica Zuluaga, Jeisson Gómez Robles, Camila Renjifo-Ibañez, Sebastián Estrada-Gómez   +7 more
doaj   +1 more source

Determining the Secondary Structure of Elapid Toxins using Multi-Layer Perceptrons and Kohonen Networks

, 2018
In this paper, a two-stage neural network consisting of a feed-forward neural network and a Kohonen self-organizing map, has been used to predict secondary structure.
, Akash Nag, Sunil Karforma
core   +1 more source

Antigenic divergence of cobra short-chain α-neurotoxins: Implications for regional antivenom effectiveness in Southeast Asia. [PDF]

PLoS Negl Trop Dis
Tan CH, Palasuberniam P, Pernee LL, Tan KY.   +3 more
europepmc   +1 more source

Effects of Cape Cobra (<i>Naja nivea</i>) Venom and Its Isolated Protein on the Modulation of Platelet Activation. [PDF]

Toxins (Basel)
Khatibi M, Almeida JR, Al Juwaiser A, Gilabadi S, Patel K, Vaiyapuri S.   +5 more
europepmc   +1 more source

A Paradigm Shift in Snakebite Envenoming Therapy: From Conventional Antivenoms to Rationally Designed, Broadly Neutralizing Combination Therapies. [PDF]

ACS Pharmacol Transl Sci
Shi N, Wang J, Xu C, Jiang X, Ren C, Gao X, Luo L.   +6 more
europepmc   +1 more source

Nanobody-based recombinant antivenom for cobra, mamba and rinkhals bites. [PDF]

Nature
Ahmadi S, Burlet NJ, Benard-Valle M, Guadarrama-Martínez A, Kerwin S, Cardoso IA, Marriott AE, Edge RJ, Crittenden E, Neri-Castro E, Fernandez-Quintero ML, Nguyen GTT, O'Brien C, Wouters Y, Kalogeropoulos K, Thumtecho S, Ebersole TW, Dahl CH, Glegg-Sørensen EU, Jansen T, Boddum K, Manousaki E, Rivera-de-Torre E, Ward AB, Morth JP, Alagón A, Mackessy SP, Ainsworth S, Menzies SK, Casewell NR, Jenkins TP, Ljungars A, Laustsen AH.   +32 more
europepmc   +1 more source

<i>In vitro</i>-<i>in vivo</i> discord: A preclinical study of AZD2716 and its racemate with comparison to varespladib for the development of snake venom sPLA2 inhibitors. [PDF]

Toxicon X
Hearth JL, Surovtseva Y, Karjala Z, Casewell NR, Giang K, Lewin MR.   +5 more
europepmc   +1 more source