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Elastase inhibition by natural flavonoids: mechanistic insights and potential therapeutic applications [PDF]

Frontiers in Nutrition
Overproduction of elastase plays an important role in the progression of inflammatory diseases. In this study, we compared the inhibitory effects of structurally similar bioactive flavonoids (quercetin, hyperoside, luteolin, and luteoloside) on elastase ...
Lihao Lin, Hongliu Yao, Jinfeng Fu, Wenhui Zhang, Yongxue Li, Yan Wang, Haoyu Shen, Jingang Mo, Yi Guan   +8 more
doaj   +2 more sources

Elastase and Elastase-Inhibitor [PDF]

Nature, 1949
WE have reported in earlier communications1,2 that the extract of fresh pancreas as well as that of acetone-dried pancreas powder contains a specific enzyme which we called 'elastase'. This enzyme had not been found before in the human or animal organism ; but it was studied first by Eijkman3 so early as 1904 as a product of bacteria.
J, BALO, I, BANGA
openaire   +5 more sources

SARS-CoV-2 Dysregulates Neutrophil Degranulation and Reduces Lymphocyte Counts

Biomedicines, 2022
SARS-CoV-2, the virus that causes COVID-19, has given rise to one of the largest pandemics, affecting millions worldwide. High neutrophil-to-lymphocyte ratios have been identified as an important correlate to poor recovery rates in severe COVID-19 ...
Abenaya Muralidharan, Todd A. Wyatt, St Patrick Reid   +2 more
doaj   +1 more source

Impact of Mt. Olympus Honeys on Virulence Factors Implicated in Pathogenesis Exerted by Pseudomonas aeruginosa

Antibiotics, 2023
The aim of this study was to examine the impact of twenty honey samples, harvested in Mt. Olympus (Greece), on the virulence factors implicated in P. aeruginosa pathogenesis.
Eleni Tsavea, Paraskevi Tzika, Eleni Katsivelou, Anna Adamopoulou, Marios Nikolaidis, Grigorios D. Amoutzias, Dimitris Mossialos   +6 more
doaj   +1 more source

Pseudomonas aeruginosa Elastase Contributes to the Establishment of Chronic Lung Colonization and Modulates the Immune Response in a Murine Model

Frontiers in Microbiology, 2021
Chronic infection by Pseudomonas aeruginosa in cystic fibrosis (CF) patients is a major contributor to progressive lung damage and is poorly treated by available antibiotic therapy.
Cristina Cigana, Jérôme Castandet, Nicolas Sprynski, Medede Melessike, Lilha Beyria, Serena Ranucci, Serena Ranucci, Beatriz Alcalá-Franco, Alice Rossi, Alessandra Bragonzi, Magdalena Zalacain, Martin Everett   +11 more
doaj   +1 more source

Selenized Chickpea Sprouts Hydrolysates as a Potential Anti-Aging Ingredient

Molecules, 2023
Skin aging represents a health and aesthetic problem that could result in infections and skin diseases. Bioactive peptides can potentially be used in skin aging regulation.
Sayra N. Serrano-Sandoval, Antonio Jiménez-Rodríguez, Jesús Hernández-Pérez, Rocio Alejandra Chavez-Santoscoy, Daniela Guardado-Félix, Marilena Antunes-Ricardo   +5 more
doaj   +1 more source

Potential Anti-aging Components From Moringa oleifera Leaves Explored by Affinity Ultrafiltration With Multiple Drug Targets

Frontiers in Nutrition, 2022
Moringa oleifera (M. oleifera), widely used in tropical and subtropical regions, has been reported to possess good anti-aging benefits on skincare.
Yongbing Xu, Yongbing Xu, Yongbing Xu, Yongbing Xu, Guilin Chen, Guilin Chen, Guilin Chen, Guilin Chen, Mingquan Guo, Mingquan Guo, Mingquan Guo, Mingquan Guo   +11 more
doaj   +1 more source

Extracellular tyrosyl‐tRNA synthetase cleaved by plasma proteinases and stored in platelet α‐granules: Potential role in monocyte activation

Research and Practice in Thrombosis and Haemostasis, 2020
Background Tyrosyl‐tRNA synthetase (YRS) belongs to the family of enzymes that catalyzes the tRNA aminoacylation reaction for protein synthesis, and it has been recently shown to exert noncanonical functions.
Eric Won, Yosuke Morodomi, Sachiko Kanaji, Ryan Shapiro, My‐Nuong Vo, Jennifer N. Orje, Courtney D. Thornburg, Xiang‐Lei Yang, Zaverio M. Ruggeri, Paul Schimmel, Taisuke Kanaji   +10 more
doaj   +1 more source

Cyanobacteria and microalgae bioactive compounds in skin-ageing: potential to restore extracellular matrix filling and overcome hyperpigmentation

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
As the largest organ in human body, skin acts as a physicochemical barrier, offering protection against harmful environmental stressors, such as chemicals, pathogens, temperature and radiation.
Rita Favas, Janaína Morone, Rosário Martins, Vitor Vasconcelos, Graciliana Lopes   +4 more
doaj   +1 more source

Biochemical Pilot Study on Effects of Pomegranate Seed Oil Extract and Cosmetic Cream on Neurologically Mediated Skin Inflammation in Animals and Humans: A Comparative Observational Study

Molecules, 2023
The presence of phenobarbital and formaldehyde in drugs, food, and beverages can lead to various health issues, including inflammation, oncogenesis, and neurological distress.
Asmaa Fathi Hamouda, Shifa Felemban
doaj   +1 more source