Results 21 to 30 of about 87,970 (343)

Neutrophil-Derived Proteases Escalate Inflammation through Activation of IL-36 Family Cytokines

Cell Reports, 2016
Recent evidence has strongly implicated the IL-1 family cytokines IL-36α, IL-36β, and IL-36γ as key initiators of skin inflammation. Similar to the other members of the IL-1 family, IL-36 cytokines are expressed as inactive precursors and require ...
Conor M. Henry, Graeme P. Sullivan, Danielle M. Clancy, Inna S. Afonina, Dagmar Kulms, Seamus J. Martin   +5 more
doaj   +1 more source

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

Journal of Cell Biology, 2010
Neutrophil elastase escapes azurophilic granules, translocates to the nucleus, and degrades histones to promote chromatin decondensation necessary for NET formation.
V. Papayannopoulos, Kathleen D. Metzler, Abdul Hakkim, A. Zychlinsky   +3 more
semanticscholar   +1 more source

Echinoclerodane A: A New Bioactive Clerodane-Type Diterpenoid from a Gorgonian Coral <em>Echinomuricea</em> sp.

Molecules, 2012
A new clerodane-type diterpenoid, echinoclerodane A (<strong>1</strong>), was isolated from a Formosan gorgonian coral <em>Echinomuricea</em> sp.
Ching-Hsiao Cheng, Hsu-Ming Chung, Tsong-Long Hwang, Mei-Chin Lu, Zhi-Hong Wen, Yueh-Hsiung Kuo, Wei-Hsien Wang, Ping-Jyun Sung   +7 more
doaj   +1 more source

Effects of the Syzygium aromaticum L. extract on antioxidation and inhibition of matrix metalloproteinase in human dermal fibroblast

Asian Pacific Journal of Tropical Biomedicine, 2019
Objective: To investigate cosmetic potential of Syzygium aromaticum L. (S. aromaticum L.) and to determine its antioxidant and anti-wrinkling effects. Methods: Using high-performance liquid chromatography, eugenol component was quantitated.
Da Eun Kim, Yeon Sil Hwang, Bo Yoon Chang, Dae Sung Kim, Hyoung Kwon Cho, Sung Yeon Kim   +5 more
doaj   +1 more source

Neutrophil elastase inhibitors [PDF]

Expert Opinion on Therapeutic Patents, 2011
Chronic obstructive pulmonary disease (COPD) constitutes a worldwide health problem. There is currently an urgent and unmet need for the development of small molecule therapeutics capable of blocking and/or reversing the progression of the disorder.
Groutas, William C., Dou, Dengfeng, Alliston, Kevin R.   +2 more
openaire   +4 more sources

Extracellular tyrosyl‐tRNA synthetase cleaved by plasma proteinases and stored in platelet α‐granules: Potential role in monocyte activation

Research and Practice in Thrombosis and Haemostasis, 2020
Background Tyrosyl‐tRNA synthetase (YRS) belongs to the family of enzymes that catalyzes the tRNA aminoacylation reaction for protein synthesis, and it has been recently shown to exert noncanonical functions.
Eric Won, Yosuke Morodomi, Sachiko Kanaji, Ryan Shapiro, My‐Nuong Vo, Jennifer N. Orje, Courtney D. Thornburg, Xiang‐Lei Yang, Zaverio M. Ruggeri, Paul Schimmel, Taisuke Kanaji   +10 more
doaj   +1 more source

Budesonide/glycopyrronium/formoterol fumarate triple therapy prevents pulmonary hypertension in a COPD mouse model via NFκB inactivation

Respiratory Research, 2022
Background Chronic obstructive pulmonary disease (COPD) is a health problem that results in death, commonly due to the development of pulmonary hypertension (PH).
Ratoe Suraya, Tatsuya Nagano, Gusty Rizky Teguh Ryanto, Wiwin Is Effendi, Daisuke Hazama, Naoko Katsurada, Masatsugu Yamamoto, Motoko Tachihara, Noriaki Emoto, Yoshihiro Nishimura, Kazuyuki Kobayashi   +10 more
doaj   +1 more source

Elastases and Elastin Degradation.

Journal of Investigative Dermatology, 1982
The metabolic turnover of mature elastin fibers in adult animals is relatively slow. Although only small amounts of elastin are degraded normally, increased degradation and fragmentation of elastic fibers may play a significant role in disease processes. Elastinolytic enzymes are found in microorganisms, snake venoms, and in a number of mammalian cells
James H. McKerrow, Michael J. Banda, Robert A. Sandhaus, Zena Werb   +3 more
openaire   +3 more sources

A point-of-care neutrophil elastase activity assay identifies bronchiectasis severity, airway infection and risk of exacerbation

European Respiratory Journal, 2019
Introduction Neutrophil elastase activity in sputum can identify patients at high risk of airway infection and exacerbations in bronchiectasis. Application of this biomarker in clinical practice is limited, because no point-of-care test is available.
A. Shoemark, E. Cant, L. Carreto, Alexandria H Smith, M. Oriano, Holly R. Keir, L. Perea, E. Cantó, L. Terranova, S. Vidal, K. Moffitt, S. Aliberti, O. Sibila, J. Chalmers   +13 more
semanticscholar   +1 more source

Culture Condition Optimization and Pilot Scale Production of the M12 Metalloprotease Myroilysin Produced by the Deep-Sea Bacterium Myroides profundi D25

Molecules, 2015
The protease myroilysin is the most abundant protease secreted by marine sedimental bacterium Myroides profundi D25. As a novel elastase of the M12 family, myroilysin has high elastin-degrading activity and strong collagen-swelling ability, suggesting ...
Xuan Shao, Li-Yuan Ran, Chang Liu, Xiu-Lan Chen, Xi-Ying Zhang, Qi-Long Qin, Bai-Cheng Zhou, Yu-Zhong Zhang   +7 more
doaj   +1 more source