pH-Responsive Elastin-Like Polypeptide Designer Condensates. [PDF]
ACS Appl Mater Interfaces, 2023 Biomolecular condensates are macromolecular complexes formed by liquid–liquid phase separation. They regulate key biological functions by reversibly compartmentalizing molecules in cells, in a stimulus-dependent manner.
de Haas RJ +3 more
europepmc +4 more sources
Multifunctional elastin-like polypeptide nanocarriers for efficient miRNA delivery in cancer therapy [PDF]
Journal of NanobiotechnologyBackground The exogenous delivery of miRNA to mimic and restore miRNA-34a activity in various cancer models holds significant promise in cancer treatment.
Jisan Hong +4 more
doaj +3 more sources
Elastin-like polypeptide coacervates as reversibly triggerable compartments for synthetic cells [PDF]
Communications ChemistryCompartmentalization is a vital aspect of living cells to orchestrate intracellular processes. In a similar vein, constructing dynamic and responsive sub-compartments is key to synthetic cell engineering.
Chang Chen +6 more
doaj +3 more sources
Construction of a Collagen-like Protein Based on Elastin-like Polypeptide Fusion and Evaluation of Its Performance in Promoting Wound Healing [PDF]
Molecules, 2023 In the healing of wounds, human-like collagen (hCol) is essential. However, collagen-based composite dressings have poor stability in vivo, which severely limits their current therapeutic potential.
Yingli Chen +9 more
doaj +3 more sources
Elastin-like Polypeptide Hydrogels for Tunable, Sustained Local Chemotherapy in Malignant Glioma [PDF]
Pharmaceutics, 2022 Glioblastoma (GBM) is a primary brain tumor that carries a dismal prognosis, which is primarily attributed to tumor recurrence after surgery and resistance to chemotherapy. Since the tumor recurrence appears near the site of surgical resection, a concept
Sonja Dragojevic +4 more
doaj +3 more sources
Exploring stimuli-responsive elastin-like polypeptide for biomedicine and beyond: potential application as programmable soft actuators [PDF]
Frontiers in Bioengineering and Biotechnology, 2023 With the emergence of soft robotics, there is a growing need to develop actuator systems that are lightweight, mechanically compliant, stimuli-responsive, and readily programmable for precise and intelligent operation.
Yeongjin Noh, Eunjoo Son, Chaenyung Cha
doaj +3 more sources
Elastin-like polypeptide modified silk fibroin porous scaffold promotes osteochondral repair [PDF]
Bioactive Materials, 2021 Silk fibroin (SF) is considered biocompatible and biodegradable for osteochondral repair. However, it lacks a bioactive domain for cell adhesion, proliferation and differentiation, limiting its therapeutic efficacy.
Zhuoyue Chen +5 more
doaj +3 more sources
Application of Elastin-like Polypeptide in Tumor Therapy. [PDF]
Cancers (Basel), 2022 Simple Summary Elastin-like Polypeptide (ELP) are widely applied in protein purification, drug delivery, tissue engineering, and even tumor therapy.
Shi X +8 more
europepmc +4 more sources
Application of Bio-Active Elastin-like Polypeptide on Regulation of Human Mesenchymal Stem Cell Behavior [PDF]
Biomedicines, 2022 Regenerative medicine using stem cells offers promising strategies for treating a variety of degenerative diseases. Regulation of stem cell behavior and rejuvenate senescence are required for stem cells to be clinically effective.
Vijaya Sarangthem +7 more
doaj +3 more sources
Application of bioengineered elastin-like polypeptide-based system for targeted gene delivery in tumor cells [PDF]
Biomaterials and Biosystems, 2022 Successful gene delivery depends on the entry of negatively charged DNAs and oligonucleotides across the various barriers of the tumor cells and localization into the nucleus for its transcription and protein translation. Here, we have reported a thermal
Aena Yi +4 more
doaj +3 more sources