A highly-sensitive genetically encoded temperature indicator exploiting a temperature-responsive elastin-like polypeptide [PDF]
Scientific Reports, 2021 Genetically encoded temperature indicators (GETIs) allow for real-time measurement of subcellular temperature dynamics in live cells. However, GETIs have suffered from poor temperature sensitivity, which may not be sufficient to resolve small heat ...
Cong Quang Vu +3 more
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Elastin-like polypeptide delivery of anti-inflammatory peptides to the brain following ischemic stroke. [PDF]
FASEB J, 2023 Inflammatory processes are activated following ischemic stroke that lead to increased tissue damage for weeks following the ischemic insult, but there are no approved therapies that target this inflammation‐induced secondary injury.
Howell JA +5 more
europepmc +3 more sources
Robust Photocontrol of Elastin-like Polypeptide Phase Transition with a Genetically Encoded Arylazopyrazole. [PDF]
ACS Synth Biol, 2023 The rational design of light-responsive proteins and protein-based polymers requires both a photoswitch with suitable light-responsive properties and the ability to incorporate it at (multiple) defined positions in the protein chain.
Strugach DS, Hadar D, Amiram M.
europepmc +2 more sources
Engineered elastin-like polypeptide improves the efficiency of adipose-derived stem cell-mediated cutaneous wound healing in type II diabetes mellitus. [PDF]
Heliyon, 2023 Impaired cutaneous wound healing is a major complication in patients with diabetes mellitus (DM), leading to increased amputation and mortality rates in affected patients.
Woo SH +5 more
europepmc +2 more sources
Extracellular Matrix-Mimetic Hydrogels for Treating Neural Tissue Injury: A Focus on Fibrin, Hyaluronic Acid, and Elastin-Like Polypeptide Hydrogels. [PDF]
Adv Healthc Mater, 2021 Neurological and functional recovery is limited following central nervous system injury and severe injury to the peripheral nervous system. Extracellular matrix (ECM)‐mimetic hydrogels are of particular interest as regenerative scaffolds for the injured ...
Nelson DW, Gilbert RJ.
europepmc +2 more sources
Elastin-like polypeptide and triclosan-modified PCL membrane provides aseptic protection in tissue regeneration. [PDF]
Mater Today BioTissue regeneration is a spatiotemporally ordered multidimensional process involving hierarchical structures, vascularization, and metabolic-immune properties, while injury often triggers structural disorganization, inflammation, metabolic dysfunction ...
Peng X +8 more
europepmc +2 more sources
Elastin-Like Polypeptides for Biomedical Applications [PDF]
Annual Review of Biomedical Engineering, 2020 Elastin-like polypeptides (ELPs) are stimulus-responsive biopolymers derived from human elastin. Their unique properties—including lower critical solution temperature phase behavior and minimal immunogenicity—make them attractive materials for a variety of biomedical applications.
Anastasia K, Varanko +2 more
openaire +4 more sources
Development of an Elastin-like Polypeptide-Based Nucleic Acid Delivery System Targeted to EGFR+ Bladder Cancer Cells Using a Layer-by-Layer Approach. [PDF]
BiomacromoleculesNucleic acid (NA)-based therapies are revolutionizing biomedical research through their ability to control cellular functions at the genetic level. This work demonstrates a versatile elastin-like polypeptide (ELP) carrier system using a layer-by-layer ...
Aayush A +4 more
europepmc +2 more sources
In situ formed depot of elastin-like polypeptide-hirudin fusion protein for long-acting antithrombotic therapy. [PDF]
Proc Natl Acad Sci U S ASignificance Anticoagulant drugs used in clinics for the prevention of thrombosis are subject to frequent administration and risk of bleeding complications. In this study, we present a long-acting and safe antithrombotic treatment strategy by integrating
Tian X +7 more
europepmc +2 more sources
αB-Crystallin Peptide Fused with Elastin-like Polypeptide: Intracellular Activity in Retinal Pigment Epithelial Cells Challenged with Oxidative Stress. [PDF]
Antioxidants (Basel), 2023 Background: Oxidative stress-induced retinal degeneration is among the main contributing factors of serious ocular pathologies that can lead to irreversible blindness.
Attia SA +11 more
europepmc +2 more sources