Results 21 to 30 of about 36,056 (184)

Solution behavior and encapsulation properties of fatty acid-elastin-like polypeptide conjugates. [PDF]

RSC Adv, 2023
Developing new biomaterials is an active research area owing to their applications in regenerative medicine, tissue engineering and drug delivery. Elastin-like polypeptides (ELPs) are good candidates for these applications because they are biosourced ...
Zhang T, Peruch F, Weber A, Bathany K, Fauquignon M, Mutschler A, Schatz C, Garbay B.   +7 more
europepmc   +2 more sources

Elastin-like polypeptides in drug delivery [PDF]

Advanced Drug Delivery Reviews, 2016
The use of recombinant elastin-like materials, or elastin-like recombinamers (ELRs), in drug-delivery applications is reviewed in this work. Although ELRs were initially used in similar ways to other, more conventional kinds of polymeric carriers, their unique properties soon gave rise to systems of unparalleled functionality and efficiency, with the ...
Rodríguez Cabello, José Carlos, Arias Vallejo, Francisco Javier, Alonso Rodrigo, Matilde, Girotti ., Alessandra   +3 more
openaire   +4 more sources

Circumventing Doxorubicin Resistance Using Elastin-like Polypeptide Biopolymer-Mediated Drug Delivery. [PDF]

Int J Mol Sci, 2022
Although doxorubicin (dox), an anthracycline antibiotic, is widely used and effective in treating cancer, its treatment efficiency is limited by low blood plasma solubility, poor pharmacokinetics, and adverse side effects, including irreversible ...
Dragojevic S, Turner L, Raucher D.
europepmc   +2 more sources

Membrane-based inverse-transition purification facilitates a rapid isolation of various spider-silk elastin-like polypeptide fusion proteins from extracts of transgenic tobacco. [PDF]

Transgenic Res
Plants can produce complex pharmaceutical and technical proteins. Spider silk proteins are one example of the latter and can be used, for example, as compounds for high-performance textiles or wound dressings.
Gruchow HM, Opdensteinen P, Buyel JF.
europepmc   +2 more sources

Targeted elastin-like polypeptide fusion protein for near-infrared imaging of human and canine urothelial carcinoma. [PDF]

Oncotarget, 2022
Cystoscopic visualization of bladder cancer is an essential method for initial bladder cancer detection and diagnosis, transurethral resection, and monitoring for recurrence. We sought to develop a new intravesical imaging agent that is more specific and
Aayush A, Darji S, Dhawan D, Enstrom A, Broman MM, Idrees MT, Kaimakliotis H, Ratliff T, Knapp D, Thompson D.   +9 more
europepmc   +2 more sources

Two-step purification of elastin-like polypeptide-fusion superoxide dismutase via hydrophobicity and thermoresponsiveness [PDF]

Frontiers in Bioengineering and Biotechnology
IntroductionSuperoxide dismutase (SOD) catalyzes the dismutation of superoxide radicals to oxygen and hydrogen peroxide, serving as a key antioxidant enzyme with important therapeutic and industrial applications.
Weiwei Wang, Weiwei Wang, Jinping Chen, Jinping Chen, Hao Zhu, Hao Zhu, Aixia Huang, Dongren Zhou, Yuchen Wang, Yang Zhou, Feng Lin, Xiangai Dong, Yu Wu   +12 more
doaj   +2 more sources

Self-assembled elastin-like polypeptide fusion protein coacervates as competitive inhibitors of advanced glycation end-products enhance diabetic wound healing. [PDF]

J Control Release, 2021
Chronic and non-healing skin wounds are some of the most significant complications in patients with advanced diabetes. A contributing mechanism to this pathology is the non-enzymatic glycation of proteins due to hyperglycemia, leading to the formation of
Kang HJ, Kumar S, D'Elia A, Dash B, Nanda V, Hsia HC, Yarmush ML, Berthiaume F.   +7 more
europepmc   +2 more sources

Applications of elastin-like polypeptides in drug delivery [PDF]

Journal of Controlled Release, 2014
Elastin-like polypeptides (ELPs) are biopolymers inspired by human elastin. Their lower critical solution temperature phase transition behavior and biocompatibility make them useful materials for stimulus-responsive applications in biological environments.
Sarah R, MacEwan, Ashutosh, Chilkoti
openaire   +4 more sources

Development of elastin-like polypeptide for targeted specific gene delivery in vivo [PDF]

Journal of Nanobiotechnology, 2020
Background The successful deliveries of siRNA depend on their stabilities under physiological conditions because greater in vivo stability enhances cellular uptake and enables endosomal escape. Viral-based systems appears as most efficient approaches for
Aena Yi, Dahye Sim, Young-Jin Lee, Vijaya Sarangthem, Rang-Woon Park   +4 more
doaj   +2 more sources

Applications of elastin-like polypeptides in tissue engineering [PDF]

Advanced Drug Delivery Reviews, 2010
Elastin-like polypeptides (ELPs) have found utility in tissue engineering applications, not only because they are biocompatible, biodegradable, and non-immunogenic, but also because their amino acid sequence and molecular weight can be precisely controlled at the genetic or synthetic level, affording exquisite control over final protein functionality ...
Dana L, Nettles, Ashutosh, Chilkoti, Lori A, Setton   +2 more
openaire   +4 more sources