Bet v 1-displaying elastin-like polypeptide nanoparticles induce a strong humoral and weak CD4+ T-cell response against Bet v 1 in a murine immunogenicity model. [PDF]
Front Immunol, 2022 There is growing concern about the toxicity of colloidal aluminum salts used as adjuvants in subcutaneous allergen immunotherapy (SCIT). Therefore, alternative adjuvants and delivery systems are being explored to replace alum in SCIT. We applied micellar
van Strien J +14 more
europepmc +2 more sources
Investigation of characteristics as endodontic sealer of novel experimental elastin-like polypeptide-based mineral trioxide aggregate [PDF]
Scientific Reports, 2021 Although mineral trioxide aggregates (MTA) have been adopted as an endodontic sealer because of excellent sealing effect and bioactive property and been modified with improvement of its characteristics, the developed MTA sealers have not yet satisfied ...
Hyun-Jung Kim +2 more
doaj +2 more sources
Targeted paclitaxel delivery in ovarian cancer via AP1-functionalized elastin-like polypeptide nanocarriers: development and characterization [PDF]
BMC CancerPaclitaxel has been a cornerstone of ovarian cancer chemotherapy for over two decades. However, its clinical application is constrained by poor solubility and non-specific delivery, resulting in systemic toxicity and inconsistent therapeutic outcomes ...
Ridhima Goel +6 more
doaj +2 more sources
FT-IR Spectroscopic Analysis of the Secondary Structures Present during the Desiccation Induced Aggregation of Elastin-Like Polypeptide on Silica. [PDF]
ACS Omega, 2020 Previously, we found that elastin-like polypeptide (ELP), when dried above the lower critical solution temperature on top of a hydrophilic fused silica disk, exhibited a dynamic coalescence behavior. The ELP initially wet the silica, but over the next 12
Cobb JS +3 more
europepmc +2 more sources
Multifunctional elastin-like polypeptide renders β-glucosidase enzyme phase transition and high stability [PDF]
Biotechnology for Biofuels, 2019 Background In the enzymatic conversion of biomass, it becomes an important issue to efficiently and cost-effectively degrade cellulose into fermentable glucose. β-Glucosidase (Bgluc), an essential member of cellulases, plays a critical role in cellulosic
Yang Zhou +10 more
doaj +2 more sources
An Elastin-like Polypeptide-fusion peptide targeting capsid-tegument interface as an antiviral against cytomegalovirus infection [PDF]
Scientific ReportsThe tegument protein pp150 of Human Cytomegalovirus (HCMV) is known to be essential for the final stages of virus maturation and mediates its functions by interacting with capsid proteins.
Komal Beeton +6 more
doaj +2 more sources
Drug delivery to solid tumors by elastin-like polypeptides [PDF]
Advanced Drug Delivery Reviews, 2010 Thermally responsive elastin-like polypeptides (ELPs) are a promising class of recombinant biopolymers for the delivery of drugs and imaging agents to solid tumors via systemic or local administration. This article reviews four applications of ELPs to drug delivery, with each delivery mechanism designed to best exploit the relationship between the ...
Jonathan R, McDaniel +2 more
openaire +4 more sources
Small StructuresElastin‐like polypeptides (ELPs), genetically programmable biomaterials derived from natural tropoelastin, exhibit unique reversible self‐assembly and aggregation behaviors driven by sequence‐encoded phase transitions.
Yang Yuan +9 more
doaj +2 more sources
Cell penetrating elastin-like polypeptides for therapeutic peptide delivery [PDF]
Advanced Drug Delivery Reviews, 2010 Current treatment of solid tumors is limited by side effects that result from the non-specific delivery of drugs to the tumor site. Alternative targeted therapeutic approaches for localized tumors would significantly reduce systemic toxicity. Peptide therapeutics are a promising new strategy for targeted cancer therapy because of the ease of peptide ...
Gene L, Bidwell, Drazen, Raucher
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Antibiofilm elastin-like polypeptide coatings: functionality, stability, and selectivity.
Acta Biomaterialia, 2019 Antimicrobial peptides (AMPs) are currently receiving interest as an alternative to conventional antibiotics to treat biomaterial-associated infection.
S. Atefyekta +4 more
semanticscholar +4 more sources