Results 71 to 80 of about 14,114 (244)

Aggregation-Dispersion Chromatography: Application of Elastin-like Polypeptides

Separations
Protein purification is a crucial step for various downstream applications like drug development, antibody preparation, and structure determination. The constant pursuit is for methods that are more efficient and cost-effective.
Han Bin Shin, Young Kee Chae
doaj   +1 more source

Thermoresponsive Polypeptide Fused L‐Asparaginase with Mitigated Immunogenicity and Enhanced Efficacy in Treating Hematologic Malignancies

Advanced Science, 2023
L‐Asparaginase (ASP) is well‐known for its excellent efficacy in treating hematological malignancies. Unfortunately, the intrinsic shortcomings of ASP, namely high immunogenicity, severe toxicity, short half‐life, and poor stability, restrict its ...
Sanke Zhang, Yuanzi Sun, Longshuai Zhang, Fan Zhang, Weiping Gao   +4 more
doaj   +1 more source

Engineered elastin-like polypeptides: An efficient platform for enhanced cancer treatment

Frontiers in Pharmacology, 2023
Drug delivery systems (DDSs) have recently gained widespread attention for improving drug loading and delivery efficiency in treating many cancers. Elastin-like polypeptides (ELPs) are synthetic peptides derived from a precursor of elastin (tropoelastin),
Aiguo Jiang, Xinqiang Guan, Lianping He, Xingang Guan, Xingang Guan   +4 more
doaj   +1 more source

Maternally sequestered therapeutic polypeptides – a new approach for the management of preeclampsia [PDF]

, 2014
The last several decades have seen intensive research into the molecular mechanisms underlying the symptoms of preeclampsia. While the underlying cause of preeclampsia is believed to be defective placental development and resulting placental ischemia ...
Eric M. George, Gene L. Bidwell
core   +2 more sources

Biophysical Characterization of an Elastin-Like-Polypeptide [PDF]

Biophysical Journal, 2011
Perhaps the largest impediment in cancer therapies has been the inability to effectively target systemically delivered therapeutics to cancerous cells. A recent and novel approach to this problem has been to chemically conjugate the therapeutic to an Elastin-Like-Polypeptide (ELP).
Lyons, Daniel, Bidwell, Gene L., Kramer, Wolfgang H., Raucher, Drazen, Correia, John J.   +4 more
openaire   +1 more source

Facile Synthesis of Peptide-Conjugated Gold Nanoclusters with Different Lengths

Nanomaterials, 2021
The synthesis of ultra-small gold nanoclusters (Au NCs) with sizes down to 2 nm has received increasing interest due to their unique optical and electronic properties.
Qun Ma, Lichao Liu, Zeyue Yang, Peng Zheng   +3 more
doaj   +1 more source

Sequence‐Modulated Active Tripeptide Condensates for Tandem Catalysis

Angewandte Chemie, Volume 138, Issue 13, 23 March 2026.
Sequence‐modulated tripeptide coacervates mimic biomolecular condensates with controllable, enzyme‐regulated phase separation. They co‐sequester hydrophobic active species and hydrophilic enzymes, enabling tandem catalysis in aqueous media. Incorporated into artificial cells, they function as adaptive sub‐organelles, orchestrating compartmentalized ...
Hao Han, Siyu Song, Jianqiang Wang, Tsvetomir Ivanov, Dongdong Zhou, Hao Su, Katharina Landfester, Shoupeng Cao   +7 more
wiley   +2 more sources

Optimisation of tennis string production from bovine intestine : a thesis presented in partial fulfilment of the requirements for the degree of Master in Technology at Massey University, Palmerston North, New Zealand [PDF]

, 1999
The collagen and elastin content of the beef thread samples ranged from between 47-70% and 1.2-2.5% respectively. Amino acid analysis showed that the collagen present was probably collagen Type I while the non-collagenous proteins predominantly were ...
Komolwattanachai, Kanda
core  

Production of the main celiac disease autoantigen by transient expression in Nicotiana benthamiana [PDF]

, 2015
Celiac Disease (CD) is a gluten sensitive enteropathy that remains widely undiagnosed and implementation of massive screening tests is needed to reduce the long term complications associated to untreated CD.
Acevedo, Gonzalo Raúl, Bayardo, Mariela Paula, Chirdo, Fernando Gabriel, Marin Viegas, Vanesa Soledad, Petruccelli, Silvana   +4 more
core   +2 more sources

Amyloidogenic Peptide Fragments Designed From Bacterial Collagen‐like Proteins Form Hydrogel

Advanced Functional Materials, EarlyView.
This study identified amyloidogenic sequence motifs in bacterial collagen‐like proteins and exploited these to design peptides that self‐assemble into β‐sheet fibers and form hydrogels. One hydrogel supported healthy fibroblast growth, showing promise for biocompatible materials. Our work demonstrates that bacterial sequences can be harnessed to create
Vamika Sagar, Xuen J Ng, Lukas Lechel, Ashish Chand Rajwar, Hendrik Bargel, Abhishek A. Jalan   +5 more
wiley   +1 more source