Results 61 to 70 of about 3,029 (158)

Mechanisms of protection of retinal pigment epithelial cells from oxidant injury by humanin and other mitochondrial-derived peptides: Implications for age-related macular degeneration

Redox Biology, 2020
The mitochondrial-derived peptides (MDPs) are a new class of small open reading frame encoded polypeptides with pleiotropic properties. The prominent members are Humanin (HN) and small HN-like peptide (SHLP) 2, which encode 16S rRNA, while mitochondrial ...
Parameswaran G. Sreekumar, Ram Kannan
doaj   +1 more source

Ocular Manifestations of Infectious Salmon Anaemia Virus Infection in Atlantic Salmon (Salmo salar)

Journal of Fish Diseases, EarlyView.
ABSTRACT Eyes are essential sensory organs needed by teleost Atlantic salmon for high visual acuity and survival in both the wild and in aquaculture settings. In this work, we assessed the ocular manifestations of Infectious Salmon Anaemia Virus (ISAV) infection in Atlantic salmon by a cohabitation‐mediated infection assay and histological and ...
Emily Mahon, Rebecca R. Kwabiah, Hélène Paradis, Manuel A. Soto‐Dávila, Sathees Duglas, Raja Ram Gurung, Thurka Paramanathan, Ignacio Vasquez, Shams Al‐Badoosh, John Law, Javier Santander, Mark D. Fast, Robert L. Gendron   +12 more
wiley   +1 more source

Controlling Release Kinetics of an Adjuvant from a Depot Improves the Efficacy of Local Immunotherapy in Metastatic Cancer

Advanced Science
Biomaterials can improve cancer immunotherapies by controlling their release and thereby optimizing their time‐dependent engagement of the immune system.
Joshua J. Milligan, Rachel L. Strader, Arunangshu Chakrabarty, Max Ney, Parul Sirohi, Jonathan C. Su, Anastasia K. Varanko, Yulia Shmidov, Kalina Tsolova, Cassio Mendes Fontes, Anna Finkelstein, Rohinee Mattikalli, Yun‐Xing Wang, Lixin Fan, Xinghai Li, Smita K. Nair, Ashutosh Chilkoti   +16 more
doaj   +1 more source

Elastin‐Like Polypeptides as a Purification Tag for Recombinant Proteins [PDF]

Current Protocols in Protein Science, 2010
AbstractThis unit presents a recombinant protein purification method that employs an elastin‐like polypeptide (ELP) as a purification tag. ELPs undergo a sharp and reversible phase transition when heated above their lower critical solution temperature.
Wafa, Hassouneh, Trine, Christensen, Ashutosh, Chilkoti   +2 more
openaire   +2 more sources

Porphyromonas gingivalis GroEL accelerates abdominal aortic aneurysm formation by matrix metalloproteinase‐2 SUMOylation in vascular smooth muscle cells: A novel finding for the activation of MMP‐2

Molecular Oral Microbiology, EarlyView.
Abstract Infection is a known cause of abdominal aortic aneurysm (AAA), and matrix metalloproteases‐2 (MMP‐2) secreted by vascular smooth muscle cells (SMCs) plays a key role in the structural disruption of the middle layer of the arteries during AAA progression.
Yi‐Wen Lin, Feng‐Yen Lin, Ze‐Hao Lai, Chien‐Sung Tsai, Yi‐Ting Tsai, Yen‐Sung Huang, Chen‐Wei Liu   +6 more
wiley   +1 more source

Fabrication of a Smart Fibrous Biomaterial That Harbors an Active TGF-β1 Peptide: A Promising Approach for Cartilage Regeneration

Biomedicines, 2023
The regeneration of articular cartilage remains a serious problem in various pathological conditions such as osteoarthritis, due to the tissue’s low self-healing capacity.
Aglaia Mantsou, Eleni Papachristou, Panagiotis Keramidas, Paraskevas Lamprou, Maria Pitou, Rigini M. Papi, Katerina Dimitriou, Amalia Aggeli, Theodora Choli-Papadopoulou   +8 more
doaj   +1 more source

Bioorthogonal Elastin-like Polypeptide Scaffolds for Immunoassay Enhancement [PDF]

ACS Applied Materials & Interfaces, 2018
Artificial multiprotein complexes are sought after reagents for biomolecular engineering. A current limiting factor is the paucity of molecular scaffolds which allow for site-specific multicomponent assembly. Here, we address this limitation by synthesizing bioorthogonal elastin-like polypeptide (ELP) scaffolds containing periodic noncanonical l ...
Duy Tien Ta, Rosario Vanella, Michael A. Nash   +2 more
openaire   +4 more sources

Design and Immunogenicity of a Nanoparticle Combination Vaccine for Salmonella in Poultry

Plant Biotechnology Journal, EarlyView.
ABSTRACT Salmonella enterica serovars (Salmonella) are common causes of bacterial gastroenteritis (salmonellosis) often associated with the consumption of poultry products. The control of Salmonella in broiler chickens is difficult because colonized birds may carry this pathogen undetected into the slaughterhouse and cause meat contamination.
Shabnam Shamriz, Angelo Kaldis, Carly A. Charron, Jordan T. VanderBurgt, Christopher P. Garnham, Moussa S. Diarra, Rima Menassa   +6 more
wiley   +1 more source

Technologies for engineering repetitive DNA

Quantitative Biology, Volume 14, Issue 3, September 2026.
Abstract Repetitive DNA, a fundamental architectural element of genomes, is widespread across organisms and comprises about 54% of the human genome. With advances in long‐read sequencing and bioinformatics approaches, highly repetitive sequences can now be characterized in depth.
Shuting Ma, Yali Cui, Yi Wu
wiley   +1 more source

Solvent Properties of Water in Aqueous Solutions of Elastin-Like Polypeptide [PDF]

International Journal of Molecular Sciences, 2015
The phase-transition temperatures of an elastin-like polypeptide (ELP) with the (GVGVP)40 sequence and solvent dipolarity/polarizability, hydrogen-bond donor acidity, and hydrogen-bond acceptor basicity in its aqueous solutions were quantified in the absence and presence of different salts (Na2SO4, NaCl, NaClO4, and NaSCN) and various osmolytes ...
Luisa Ferreira, James Cole, Christian Reichardt, Nolan Holland, Vladimir Uversky, Boris Zaslavsky   +5 more
openaire   +3 more sources