Results 71 to 80 of about 3,029 (158)

Deep Mutational Scanning for the Study and Engineering of Protein Assemblies

Chemistry–Methods, Volume 6, Issue 8, August 2026.
This review explores how deep mutational scanning (DMS) can be used to improve understanding and accelerate engineering of protein assemblies, from natural fibers to engineered nanocages. We discuss various types of protein assemblies and their characterization, provide an introduction to the DMS technique, and then highlight examples in which DMS has ...
Jenna B. Wolfanger, Shoili Banerjee, Carolyn E. Mills   +2 more
wiley   +1 more source

3D Liver Fibrosis Models in Lab: A Novel Modality for Drug Screening

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Liver fibrosis is the common consequence of liver injury caused by a variety of chronic liver disorders. This condition leads to the development of more severe complications, particularly cirrhosis and hepatocellular carcinoma. Despite abundant studies, the fundamental cell and molecular mechanisms of liver fibrosis are still unknown.
Hani Keshavarz Alikhani, Fatemeh Majidi, Mahsa Ghasemzad, Anastasia Shpichka, Anastasia Nestorova, Zahra Hendi, Elham Rismani, Daria Kuznetsova, Peter Timashev, Massoud Vosough, Abbas Piryaei   +10 more
wiley   +1 more source

Dermatological, Trichological and Quality of Life Consequences of GLP‐1 Receptor Agonist‐Mediated Weight Loss: A US Cross‐Sectional Survey

Journal of Cosmetic Dermatology, Volume 25, Issue 8, August 2026.
ABSTRACT Background Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs), including dual glucagon‐like peptide‐1/glucose‐dependent insulinotropic polypeptide (GLP‐1/GIP) receptor agonists, have revolutionized obesity management, resulting in significant medication‐driven weight loss (MDWL). Despite widespread reporting, the dermatological consequences
Janet Wangari Olivero, Jyotsna Paturi, Magali Moreau, Kun Qian, Stacy‐Ann Stevenson, Yaxian Zhen, Qian Zheng   +6 more
wiley   +1 more source

Natural Biomaterials for Osteochondral Repair: From Source to Strategy

Advanced Healthcare Materials, Volume 15, Issue 27, 17 July 2026.
Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu, Hanyang Zhang, Wenbo Yang, Hao Chen, Jincheng Wang, Fei Chang   +5 more
wiley   +1 more source

Cell Adhesion by Design: Engineering Tissue Culture Scaffolds With Adhesion Cues

Advanced Materials Interfaces, Volume 13, Issue 13, 7 July 2026.
ABSTRACT In scaffold‐based tissue engineering, the matrix should provide adequate adhesion cues for cell attachment, spreading, and function. Given the multitude of adhesion receptors and the diversity of scaffolds, there are many approaches to render scaffolds adhesive, even though they are not all equivalent.
Dalia Dranseike, Dhananjay V. Deshmukh, Mark W. Tibbitt, Céline Labouesse   +3 more
wiley   +1 more source

Elastin-like polypeptides in radiopharmaceutical delivery: current evidence, design principles, and translational challenges

Frontiers in Biomaterials Science
Elastin-like polypeptides (ELPs) are genetically engineered protein polymers with tunable sequences, molecular weights, phase-transition temperatures, and functional sites. Their programmable and thermoresponsive properties allow control over solubility,
Haidong Tian, Haidong Tian, Kepei Yang, Hongyan Li, Jianxi Xiao   +4 more
doaj   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, Volume 293, Issue 13, Page 3899-3953, July 2026.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

Thermoresponsive and Protease‐Cleavable Interferon‐Polypeptide Conjugates with Spatiotemporally Programmed Two‐Step Release Kinetics for Tumor Therapy

Advanced Science, 2019
Protein‐polymer conjugates show improved pharmacokinetics but reduced bioactivity and tumor penetration as compared to native proteins, resulting in limited antitumor efficacy. To address this dilemma, genetic engineering of a body temperature‐responsive
Zhuoran Wang, Jianwen Guo, Jiawei Sun, Ping Liang, Yan Wei, Xuliang Deng, Weiping Gao   +6 more
doaj   +1 more source

Enzymatic Prenylation of Proteins and Peptides: From Cysteine S‐Prenylation to Tryptophan‐Selective Biocatalysis

Chemistry – A European Journal, Volume 32, Issue 24, 23 June 2026.
This review highlights biocatalytic prenylation as a versatile strategy for tailoring the functional properties of peptides and proteins. By comparing branched isoprenoids with linear lipids, we illustrate how specific prenyl architectures modulate the behaviors of lipidated proteins within membrane environments.
Daisuke Fujinami, Hikari Ozawa, Sohei Ito   +2 more
wiley   +1 more source

Genetically engineered nanocarriers for drug delivery

International Journal of Nanomedicine, 2014
Pu Shi, Joshua A Gustafson, J Andrew MacKayDepartment of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA, USAAbstract: Cytotoxicity, low water solubility, rapid clearance from circulation, and off-target side ...
Shi P, Gustafson JA, MacKay JA
doaj