Results 1 to 10 of about 384,643 (224)

Advanced modeling of bioenergetics in the mitochondrial electron transport chain with emphasis on complex IV [PDF]

Alzheimers Dement
AbstractBackgroundMitochondrial bioenergetics are essential for cellular function, specifically the intricacies of the electron transport chain (ETC), with Complex IV playing a crucial role in unraveling the mechanisms governing energy production. Mathematical models offer a valuable approach to simulate these complex processes, providing insights into
Keleshteri M, Cadonic C, Ghafourian T, Thomson E, Snow W, McAllister D, Djordjevic J, Chowdhury S, Fernyhough P, Fiege J, Portet S, Albensi B.   +11 more
europepmc   +2 more sources

NDUFA4 Is a Subunit of Complex IV of the Mammalian Electron Transport Chain [PDF]

Cell Metabolism, 2012
The oxidative phosphorylation system is one of the best-characterized metabolic pathways. In mammals, the protein components and X-ray structures are defined for all complexes except complex I. Here, we show that NDUFA4, formerly considered a constituent of NADH Dehydrogenase (CI), is instead a component of the cytochrome c oxidase (CIV).
Ester Perales-Clemente, Radek Szklarczyk, Ricardo Marco, José Antonio Enríquez, José Antonio Enríquez, Manuel O. Landázuri, Eduardo Balsa, Eduardo Balsa, Enrique Calvo   +8 more
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Ascorbate Biosynthesis in Mitochondria Is Linked to the Electron Transport Chain between Complexes III and IV [PDF]

Plant Physiology, 2000
Abstract Ascorbic acid is synthesized from galactono-γ-lactone (GL) in plant tissues. An improved extraction procedure involving ammonium sulfate precipitation of membrane proteins from crude leaf homogenates yielded a simple, quick method for determining tissue activities of galactono-γ-lactone dehydrogenase (GLDH).
Bartoli, Carlos Guillermo, Pastori, Gabriela M., Foyer, Christine H.   +2 more
openaire   +3 more sources

Glutathionylated and Fe–S cluster containing hMIA40 (CHCHD4) regulates ROS and mitochondrial complex III and IV activities of the electron transport chain

Redox Biology, 2020
Human MIA40, an intermembrane space (IMS) import receptor of mitochondria harbors twin CX9C motifs for stability while its CPC motif is known to facilitate the import of IMS bound proteins. Site-directed mutagenesis complemented by MALDI on in vivo hMIA40 protein shows that a portion of MIA40 undergoes reversible S-glutathionylation at three cysteines ...
Venkata Ramana Thiriveedi, Ushodaya Mattam, Prasad Pattabhi, Vandana Bisoyi, Noble Kumar Talari, Thanuja Krishnamoorthy, Naresh Babu V. Sepuri   +6 more
openaire   +4 more sources

A Structural Model of the Cytochrome c Reductase/Oxidase Supercomplex from Yeast Mitochondria [PDF]

, 2007
Mitochondrial respiratory chain complexes are arranged in supercomplexes within the inner membrane. Interaction of cytochrome c reductase (complex III) and cytochrome c oxidase (complex IV) was investigated in Saccharomyces cerevisiae. Projection maps at
Allen, Berry, Boumans, Cruciat, DeLano, Dudkina, Dudkina, Dudkina, Dudkina, Giraud, Guex, Harris, Heinemeyer, Khalimonchuk, Kim, Lange, Lee, Ludtke, Mannella, Meisinger, Minauro-Sanmiguel, Neuhoff, Paumard, Pearce, Penczek, Pfeiffer, Roberts, Saraste, Schwerzmann, Schäfer, Schägger, Schägger, Schägger, Schägger, Stroh, Sunderhaus, Tsukihara, Van Heel, Van Heel, Wittig, Wittig, Zerbetto, Zhang, Zhang   +43 more
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Structural organisation of the type IV secretion systems [PDF]

, 2014
Type IV secretion (T4S) systems are large dynamic nanomachines that transport DNAs and/or proteins through the membranes of bacteria. Because of their complexity and multi-protein organisation, T4S systems have been extremely challenging to study ...
Abdallah, Alvarez-Martinez, Arechaga, Atmakuri, Backert, Bailey, Buscher, Cascales, Cascales, Cascales, Chandran, Christie, Cornelis, Dang, de Jong, Durand, Elena V Orlova, Filloux, Fronzes, Gabriel Waksman, Garza, Giraldo, Goessweiner-Mohr, Gomis-Rüth, Hare, Hare, Henderson, Hofreuter, Jakubowski, Jones, Lederberg, Lessl, Li, Llosa, Mossey, Ninio, Omori, O’Callaghan, Pansegrau, Peña, Porter, Ripoll-Rozada, Rivera-Calzada, Savvides, Segura, Smith, Sutherland, Terradot, Waksman, Walldén, Yeo   +50 more
core   +1 more source

Structure of a bacterial type IV secretion core complex at subnanometre resolution [PDF]

, 2013
Type IV secretion (T4S) systems are able to transport DNAs and/or proteins through the membranes of bacteria. They form large multiprotein complexes consisting of 12 proteins termed VirB1-11 and VirD4.
Chandran, Vidya, Fronzes, Remi, Laeremans, T., Lian, Pei W., Orlova, Elena, Pardon, E., Remaut, Han, Rivera-Calzada, A., Savva, Christos G., Steyaert, J., Waksman, Gabriel   +10 more
core   +1 more source

Identification of a Protein Mediating Respiratory Supercomplex Stability [PDF]

, 2012
SummaryThe complexes of the electron transport chain associate into large macromolecular assemblies, which are believed to facilitate efficient electron flow.
Chen, Yu-Chan, Denko, Nicolas C., Dephoure, Noah, Gygi, Steven P., Heo, Jin-Mi, Nath, Nandita, Papandreou, Ioanna, Rutter, Jared, Taylor, Eric B., Tonhato, Aline   +9 more
core   +1 more source

Age-related deficiencies in complex I endogenous substrate availability and reserve capacity of complex IV in cortical neuron electron transport

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2010
Respiratory enzyme complex dysfunction is mechanistically involved in mitochondrial failure leading to neurodegenerative disease, but the pathway is unclear. Here, age-related differences in mitochondrial respiration were measured in both whole and permeabilized neurons from 9-month and 24-month adult rat cortex cultured in common conditions.
Gregory J. Brewer, Torrie T. Jones
openaire   +3 more sources

Surface Fluorescence Studies of Tissue Mitochondrial Redox State in Isolated Perfused Rat Lungs [PDF]

, 2012
We designed a fiber-optic-based optoelectronic fluorometer to measure emitted fluorescence from the auto-fluorescent electron carriers NADH and FAD of the mitochondrial electron transport chain (ETC).
Audi, Said H., Jacobs, Elizabeth R., Ranji, Mahsa, Sepehr, Reyhaneh, Staniszewski, Kevin   +4 more
core   +2 more sources