Results 1 to 10 of about 441,339 (185)

Glutathionylated and Fe–S cluster containing hMIA40 (CHCHD4) regulates ROS and mitochondrial complex III and IV activities of the electron transport chain

Redox Biology, 2020
Human MIA40, an intermembrane space (IMS) import receptor of mitochondria harbors twin CX9C motifs for stability while its CPC motif is known to facilitate the import of IMS bound proteins. Site-directed mutagenesis complemented by MALDI on in vivo hMIA40 protein shows that a portion of MIA40 undergoes reversible S-glutathionylation at three cysteines ...
Venkataramana Thiriveedi, Ushodaya Mattam, Prasad Pattabhi, Vandana Bisoyi, Noble Kumar Talari, T.M. Krishnamoorthy, Naresh Babu V. Sepuri   +6 more
doaj   +7 more sources

NDUFA4 Is a Subunit of Complex IV of the Mammalian Electron Transport Chain [PDF]

Cell Metabolism, 2012
The oxidative phosphorylation system is one of the best-characterized metabolic pathways. In mammals, the protein components and X-ray structures are defined for all complexes except complex I. Here, we show that NDUFA4, formerly considered a constituent of NADH Dehydrogenase (CI), is instead a component of the cytochrome c oxidase (CIV).
Eduardo Balsa, Ricardo De Marco, Ester Perales‐Clemente, Radek Szklarczyk, Enrique Calvo, Manuel O. Landázuri, José Antonio Enrı́quez   +6 more
semanticscholar   +6 more sources

Age-related deficiencies in complex I endogenous substrate availability and reserve capacity of complex IV in cortical neuron electron transport [PDF]

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2009
Respiratory enzyme complex dysfunction is mechanistically involved in mitochondrial failure leading to neurodegenerative disease, but the pathway is unclear. Here, age-related differences in mitochondrial respiration were measured in both whole and permeabilized neurons from 9-month and 24-month adult rat cortex cultured in common conditions.
Torrie T. Jones, Gregory J. Brewer
semanticscholar   +5 more sources

Ascorbate Biosynthesis in Mitochondria Is Linked to the Electron Transport Chain between Complexes III and IV [PDF]

Plant Physiology, 2000
Abstract Ascorbic acid is synthesized from galactono-γ-lactone (GL) in plant tissues. An improved extraction procedure involving ammonium sulfate precipitation of membrane proteins from crude leaf homogenates yielded a simple, quick method for determining tissue activities of galactono-γ-lactone dehydrogenase (GLDH).
Carlos G. Bartoli, G. M. Pastori, Christine H. Foyer   +2 more
openalex   +5 more sources

COX4I1 Controls Mitochondrial Electron Transport Chain Complex IV Assembly and Leukemia Progression in Acute Myeloid Leukemia

Blood, 2023
Aberrant cellular signaling plays a pivotal role in the pathogenesis of acute myeloid leukemia (AML). Identifying key signaling components and their dependencies is crucial for advancing AML therapy. Here, we conducted a focused CRISPR library screen targeting 427 cell signaling-related genes with 3,416 sgRNAs (8 sgRNAs per gene) in the
Leisi Zhang, Mingli Li, Anthony K. N. Chan, Qiao Liu, HyunJun Kang, Sheela Pangeni Pokharel, Nicole Mattson, Priyanka Singh, Lu Yang, Chun–Wei Chen   +9 more
openalex   +2 more sources

Mitochondrial Function and Parkinson’s Disease: From the Perspective of the Electron Transport Chain

Frontiers in Molecular Neuroscience, 2021
Parkinson’s disease (PD) is known as a mitochondrial disease. Some even regarded it specifically as a disorder of the complex I of the electron transport chain (ETC).
Jeng-Lin Li, Jeng-Lin Li, Tai-Yi Lin, Po-Lin Chen, Ting-Ni Guo, Shu-Yi Huang, Chun-Hong Chen, Chin-Hsien Lin, Chin-Hsien Lin, Chih-Chiang Chan   +9 more
doaj   +2 more sources

Respiratory electron transfer pathways in plant mitochondria [PDF]

Frontiers in Plant Science, 2014
The respiratory electron transport chain (ETC) couples electron transfer from organic substrates onto molecular oxygen with proton translocation across the inner mitochondrial membrane.
Peter eSchertl, Hans-Peter eBraun
doaj   +5 more sources

Advanced modeling of bioenergetics in the mitochondrial electron transport chain with emphasis on complex IV

Alzheimer's & Dementia
AbstractBackgroundMitochondrial bioenergetics are essential for cellular function, specifically the intricacies of the electron transport chain (ETC), with Complex IV playing a crucial role in unraveling the mechanisms governing energy production. Mathematical models offer a valuable approach to simulate these complex processes, providing insights into
Marzieh Eini Keleshteri, Chris Cadonic, Taravat Ghafourian, Ella A. Thomson, Wanda M. Snow, Danielle McAllister, Jelena Djordjevic, Subir Roy Chowdhury, Paul Fernyhough, Jason Fiege, Stéphanie Portet, Benedict C. Albensi   +11 more
openalex   +2 more sources

Structural studies of T4S systems by electron microscopy [PDF]

AIMS Biophysics, 2015
Type IV secretion (T4S) systems are large dynamic nanomachines that transport DNA and/or proteins through the membranes of bacteria. Analysis of T4S system architecture is an extremely challenging task taking into account their multi protein organisation
Adam Redzej, Gabriel Waksman, Elena V Orlova   +2 more
doaj   +3 more sources

Evaluation of functioning of mitochondrial electron transport chain with NADH and FAD autofluorescence [PDF]

The Ukrainian Biochemical Journal, 2016
We prove the feasibility of evaluation of mitochondrial electron transport chain function in isolated mitochondria of smooth muscle cells of rats from uterus using fluorescence of NADH and FAD coenzymes. We found the inversely directed changes in FAD and
H. V. Danylovych
doaj   +2 more sources