Results 11 to 20 of about 441,339 (185)

Near-infrared 808 nm light boosts complex IV-dependent respiration and rescues a Parkinson-related pink1 model. [PDF]

PLoS ONE, 2013
Mitochondrial electron transport chain (ETC) defects are observed in Parkinson's disease (PD) patients and in PD fly- and mouse-models; however it remains to be tested if acute improvement of ETC function alleviates PD-relevant defects.
Melissa Vos, Blaise Lovisa, Ann Geens, Vanessa A Morais, Georges Wagnières, Hubert van den Bergh, Alec Ginggen, Bart De Strooper, Yanik Tardy, Patrik Verstreken   +9 more
doaj   +2 more sources

Hyperoxia decreases glycolytic capacity, glycolytic reserve and oxidative phosphorylation in MLE-12 cells and inhibits complex I and II function, but not complex IV in isolated mouse lung mitochondria.

PLoS ONE, 2013
High levels of oxygen (hyperoxia) are frequently used in critical care units and in conditions of respiratory insufficiencies in adults, as well as in infants.
Kumuda C Das
doaj   +2 more sources

The mechanism of Intralipid®-mediated cardioprotection complex IV inhibition by the active metabolite, palmitoylcarnitine, generates reactive oxygen species and activates reperfusion injury salvage kinases. [PDF]

PLoS ONE, 2014
Intralipid® administration at reperfusion elicits protection against myocardial ischemia-reperfusion injury. However, the underlying mechanisms are not fully understood.Sprague-Dawley rat hearts were exposed to 15 min of ischemia and 30 min of ...
Phing-How Lou, Eliana Lucchinetti, Liyan Zhang, Andreas Affolter, Marcus C Schaub, Manoj Gandhi, Martin Hersberger, Blair E Warren, Hélène Lemieux, Hany F Sobhi, Alexander S Clanachan, Michael Zaugg   +11 more
doaj   +2 more sources

Reversible Thiol Oxidation Increases Mitochondrial Electron Transport Complex Enzyme Activity but Not Respiration in Cardiomyocytes from Patients with End-Stage Heart Failure

bioRxiv, 2022
Cardiomyocyte dysfunction in patients with end-stage heart failure with reduced ejection fraction (HFrEF) stems from mitochondrial dysfunction that contributes to an energetic crisis.
Ravi A. Kumar, T. Thome, Omar Sharaf, Terence E. Ryan, G. Arnaoutakis, E. Jeng, L. Ferreira   +6 more
semanticscholar   +1 more source

APOE expression and secretion are modulated by mitochondrial dysfunction

eLife, 2023
Mitochondria influence cellular function through both cell-autonomous and non-cell autonomous mechanisms, such as production of paracrine and endocrine factors.
Meghan E Wynne, Oluwaseun Ogunbona, Alicia R Lane, Avanti Gokhale, Stephanie A Zlatic, Chongchong Xu, Zhexing Wen, Duc M Duong, Sruti Rayaprolu, Anna Ivanova, Eric A Ortlund, Eric B Dammer, Nicholas T Seyfried, Blaine R Roberts, Amanda Crocker, Vinit Shanbhag, Michael Petris, Nanami Senoo, Selvaraju Kandasamy, Steven Michael Claypool, Antoni Barrientos, Aliza Wingo, Thomas S Wingo, Srikant Rangaraju, Allan I Levey, Erica Werner, Victor Faundez   +26 more
doaj   +1 more source

New insight into the mechanism of mitochondrial cytochrome c function. [PDF]

PLoS ONE, 2017
We investigate functional role of the P76GTKMIFA83 fragment of the primary structure of cytochrome c. Based on the data obtained by the analysis of informational structure (ANIS), we propose a model of functioning of cytochrome c. According to this model,
Rita V Chertkova, Nadezda A Brazhe, Tatiana V Bryantseva, Alexey N Nekrasov, Dmitry A Dolgikh, Alexander I Yusipovich, Olga Sosnovtseva, Georgy V Maksimov, Andrei B Rubin, Mikhail P Kirpichnikov   +9 more
doaj   +1 more source

ETMB-RBF: discrimination of metal-binding sites in electron transporters based on RBF networks with PSSM profiles and significant amino acid pairs. [PDF]

PLoS ONE, 2013
BACKGROUND: Cellular respiration is the process by which cells obtain energy from glucose and is a very important biological process in living cell. As cells do cellular respiration, they need a pathway to store and transport electrons, the electron ...
Yu-Yen Ou, Shu-An Chen, Sheng-Cheng Wu
doaj   +1 more source

Ophiobolin A Covalently Targets Complex IV Leading to Mitochondrial Metabolic Collapse in Cancer Cells

bioRxiv, 2023
Summary Ophiobolin A (OPA) is a sesterterpenoid fungal natural product with broad anti-cancer activity. While OPA possesses multiple electrophilic moieties that can covalently react with nucleophilic amino acids on proteins, the proteome-wide targets and
Flor A. Gowans, Danny Q. Thach, Yangzhi Wang, Belen E Altamirano Poblano, Dustin Dovala, John A. Tallarico, J. McKenna, M. Schirle, T. Maimone, Dan Nomura   +9 more
semanticscholar   +1 more source

An essential role for an Fe-S cluster protein in the cytochrome c oxidase complex of Toxoplasma parasites.

PLoS Pathogens, 2023
The mitochondrial electron transport chain (ETC) of apicomplexan parasites differs considerably from the ETC of the animals that these parasites infect, and is the target of numerous anti-parasitic drugs.
Rachel A Leonard, Yuan Tian, Feng Tan, Giel G van Dooren, Jenni A Hayward   +4 more
doaj   +1 more source

Structural basis of mammalian complex IV inhibition by steroids

bioRxiv, 2022
The mitochondrial electron transport chain maintains the proton motive force that powers ATP synthesis. The energy for this process comes from oxidation of NADH and succinate, with the electrons from this oxidation passed via intermediate carriers to ...
Justin M. Di Trani, A. Moe, Daniel Riepl, Patricia Saura, Ville R. I. Kaila, P. Brzezinski, J. Rubinstein   +6 more
semanticscholar   +1 more source