Results 21 to 30 of about 628,628 (257)

Enhancing mitochondrial activity in neurons protects against neurodegeneration in a mouse model of multiple sclerosis

eLife, 2021
While transcripts of neuronal mitochondrial genes are strongly suppressed in central nervous system inflammation, it is unknown whether this results in mitochondrial dysfunction and whether an increase of mitochondrial function can rescue ...
Sina C Rosenkranz, Artem A Shaposhnykov, Simone Träger, Jan Broder Engler, Maarten E Witte, Vanessa Roth, Vanessa Vieira, Nanne Paauw, Simone Bauer, Celina Schwencke-Westphal, Charlotte Schubert, Lukas Can Bal, Benjamin Schattling, Ole Pless, Jack van Horssen, Marc Freichel, Manuel A Friese   +16 more
doaj   +1 more source

Tissue-specific mitochondrial HIGD1C promotes oxygen sensitivity in carotid body chemoreceptors

eLife, 2022
Mammalian carotid body arterial chemoreceptors function as an early warning system for hypoxia, triggering acute life-saving arousal and cardiorespiratory reflexes. To serve this role, carotid body glomus cells are highly sensitive to decreases in oxygen
Alba Timón-Gómez, Alexandra L Scharr, Nicholas Y Wong, Erwin Ni, Arijit Roy, Min Liu, Julisia Chau, Jack L Lampert, Homza Hireed, Noah S Kim, Masood Jan, Alexander R Gupta, Ryan W Day, James M Gardner, Richard JA Wilson, Antoni Barrientos, Andy J Chang   +16 more
doaj   +1 more source

Respiratory electron transfer pathways in plant mitochondria

Frontiers in Plant Science, 2014
The respiratory electron transport chain (ETC) couples electron transfer from organic substrates onto molecular oxygen with proton translocation across the inner mitochondrial membrane.
Peter eSchertl, Hans-Peter eBraun
doaj   +1 more source

Phenotypic continuum of NFU1‐related disorders

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 2025-2035, December 2022., 2022
Abstract Bi‐allelic variants in Iron–Sulfur Cluster Scaffold (NFU1) have previously been associated with multiple mitochondrial dysfunctions syndrome 1 (MMDS1) characterized by early‐onset rapidly fatal leukoencephalopathy. We report 19 affected individuals from 10 independent families with ultra‐rare bi‐allelic NFU1 missense variants associated with a
Rauan Kaiyrzhanov, Maha S. Zaki, Tracy Lau, Sambuddha Sen, Reza Azizimalamiri, Mina Zamani, Gözde Yeşil Sayin, Taru Hilander, Stephanie Efthymiou, Viorica Chelban, Ruth Brown, Kyle Thompson, Maria Irene Scarano, Jaya Ganesh, Kairgali Koneev, Ismail Musab Gülaçar, Richard Person, Dinara Sadykova, Yerdan Maidyrov, Tahereh Seifi, Aizhan Zadagali, Geneviève Bernard, Katrina Allis, Houda Zghal Elloumi, Amanda Lindy, Ehsan Taghiabadi, Sumit Verma, Rachel Logan, Brian Kirmse, Renkui Bai, Shaimaa M. Khalaf, Mohamed S. Abdel‐Hamid, Alireza Sedaghat, Gholamreza Shariati, Mahmoud Issa, Jawaher Zeighami, Hasnaa M. Elbendary, Garry Brown, Robert W. Taylor, Hamid Galehdari, Joseph J. Gleeson, Christopher J. Carroll, James A. Cowan, Andres Moreno‐De‐Luca, Henry Houlden, Reza Maroofian   +45 more
wiley   +1 more source

Glutathione binding to the plant AtAtm3 transporter and implications for the conformational coupling of ABC transporters

eLife, 2022
The ATP binding cassette (ABC) transporter of mitochondria (Atm) from Arabidopsis thaliana (AtAtm3) has been implicated in the maturation of cytosolic iron-sulfur proteins and heavy metal detoxification, plausibly by exporting glutathione derivatives ...
Chengcheng Fan, Douglas C Rees
doaj   +1 more source

Brownian dynamics simulation of cytochrome c diffusion and binding with cytochrome c1 in mitochondrial crista [PDF]

ITM Web of Conferences, 2020
Cytochrome c (Cc) protein shuttles electrons from respiratory chain complex III — from cytochrome c1 (Cc1) subunit — to complex IV during oxidative phosphorylation, in intermembrane space of mitochondria and cristae lumen.
Abaturova Anna M., Brazhe Nadezda A., Kovalenko Ilya B., Riznichenko Galina Yu, Rubin Andrei B.   +4 more
doaj   +1 more source

Near-infrared 808 nm light boosts complex IV-dependent respiration and rescues a Parkinson-related pink1 model. [PDF]

PLoS ONE, 2013
Mitochondrial electron transport chain (ETC) defects are observed in Parkinson's disease (PD) patients and in PD fly- and mouse-models; however it remains to be tested if acute improvement of ETC function alleviates PD-relevant defects.
Melissa Vos, Blaise Lovisa, Ann Geens, Vanessa A Morais, Georges Wagnières, Hubert van den Bergh, Alec Ginggen, Bart De Strooper, Yanik Tardy, Patrik Verstreken   +9 more
doaj   +1 more source

Sordaria macrospora Sterile Mutant pro34 Is Impaired in Respiratory Complex I Assembly

Journal of Fungi, 2022
The formation of fruiting bodies is a highly regulated process that requires the coordinated formation of different cell types. By analyzing developmental mutants, many developmental factors have already been identified.
Andrea Hamann, Heinz D. Osiewacz, Ines Teichert   +2 more
doaj   +1 more source

Quantum Transport in Semiconductor Nanostructures [PDF]

Solid State Physics 44, 1 (1991), 2004
I. Introduction (Preface, Nanostructures in Si Inversion Layers, Nanostructures in GaAs-AlGaAs Heterostructures, Basic Properties). II. Diffusive and Quasi-Ballistic Transport (Classical Size Effects, Weak Localization, Conductance Fluctuations, Aharonov-Bohm Effect, Electron-Electron Interactions, Quantum Size Effects, Periodic Potential).
arxiv   +1 more source

Hyperoxia decreases glycolytic capacity, glycolytic reserve and oxidative phosphorylation in MLE-12 cells and inhibits complex I and II function, but not complex IV in isolated mouse lung mitochondria.

PLoS ONE, 2013
High levels of oxygen (hyperoxia) are frequently used in critical care units and in conditions of respiratory insufficiencies in adults, as well as in infants.
Kumuda C Das
doaj   +1 more source