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A Biophysical Model of the Mitochondrial Respiratory System and Oxidative Phosphorylation. [PDF]
A computational model for the mitochondrial respiratory chain that appropriately balances mass, charge, and free energy transduction is introduced and analyzed based on a previously published set of data measured on isolated cardiac mitochondria.
Daniel A Beard
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We studied Arabidopsis HYPOXIA-RESPONSIVE MODULATOR 1 (HRM1), which belongs to a group of core hypoxia-responsive genes that are conserved among plant species across great evolutionary distance.
K.-J. Tsai, D. Suen, M. Shih
semanticscholar +1 more source
Male and Female Mitochondria Respond Differently after Exercising in Acute Hypoxia
The use of hypoxic devices among athletes who train in normobaric hypoxia has become increasingly popular; however, the acute effects on heart and brain metabolism are not yet fully understood.
Ylenia Lai+8 more
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The role of the electron transport chain in immunity
The electron transport chain (ETC) couples oxidative phosphorylation (OXPHOS) with ATP synthase to drive the generation of ATP. In immune cells, research surrounding the ETC has drifted away from bioenergetics since the discovery of cytochrome c (Cyt c ...
Maureen Yin, L. O’Neill
semanticscholar +1 more source
Mitochondrial morphology is associated with respiratory chain uncoupling in autism spectrum disorder
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is associated with unique changes in mitochondrial metabolism, including elevated respiration rates and morphological alterations.
Richard E. Frye+13 more
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Regulation and functional role of the electron transport chain supercomplexes
Mitochondria are one of the most exhaustively investigated organelles in the cell and most attention has been paid to the components of the mitochondrial electron transport chain (ETC) in the last 100 years.
S. Cogliati+2 more
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Pulmonary hypertension is associated with pronounced exercise intolerance (decreased V ċ O 2 max) that can significantly impact quality of life. The cause of exercise intolerance in pulmonary hypertension remains unclear. Mitochondrial supercomplexes are
Danielle J. McCullough+5 more
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While transcripts of neuronal mitochondrial genes are strongly suppressed in central nervous system inflammation, it is unknown whether this results in mitochondrial dysfunction and whether an increase of mitochondrial function can rescue ...
Sina C Rosenkranz+16 more
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Tissue-specific mitochondrial HIGD1C promotes oxygen sensitivity in carotid body chemoreceptors
Mammalian carotid body arterial chemoreceptors function as an early warning system for hypoxia, triggering acute life-saving arousal and cardiorespiratory reflexes. To serve this role, carotid body glomus cells are highly sensitive to decreases in oxygen
Alba Timón-Gómez+16 more
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Respiratory electron transfer pathways in plant mitochondria
The respiratory electron transport chain (ETC) couples electron transfer from organic substrates onto molecular oxygen with proton translocation across the inner mitochondrial membrane.
Peter eSchertl, Hans-Peter eBraun
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