Results 31 to 40 of about 142 (64)

Recessive pathogenic variants in MCAT cause combined oxidative phosphorylation deficiency

eLife, 2023
Malonyl-CoA-acyl carrier protein transacylase (MCAT) is an enzyme involved in mitochondrial fatty acid synthesis (mtFAS) and catalyzes the transfer of the malonyl moiety of malonyl-CoA to the mitochondrial acyl carrier protein (ACP).
Bryn D Webb, Sara M Nowinski, Ashley Solmonson, Jaya Ganesh, Richard J Rodenburg, Joao Leandro, Anthony Evans, Hieu S Vu, Thomas P Naidich, Bruce D Gelb, Ralph J DeBerardinis, Jared Rutter, Sander M Houten   +12 more
doaj   +1 more source

Impaired exercise performance and skeletal muscle mitochondrial function in rats with secondary carnitine deficiency

Frontiers in Physiology, 2016
Purpose: The effects of carnitine depletion upon exercise performance and skeletal muscle mitochondrial function remain largely unexplored. We therefore investigated the effect of N-trimethyl-hydrazine-3-propionate (THP), a carnitine analogue inhibiting ...
Jamal BOUITBIR, Patrizia HAEGLER, François SINGH, Lorenz JOERIN, Andrea FELSER, Urs DUTHALER, Stephan KRAEHENBUEHL   +6 more
doaj   +1 more source

Organization of the Respiratory Supercomplexes in Cells with Defective Complex III: Structural Features and Metabolic Consequences

Life, 2021
The mitochondrial respiratory chain encompasses four oligomeric enzymatic complexes (complex I, II, III and IV) which, together with the redox carrier ubiquinone and cytochrome c, catalyze electron transport coupled to proton extrusion from the inner ...
Michela Rugolo, Claudia Zanna, Anna Maria Ghelli   +2 more
doaj   +1 more source

Mitochondrial Electron Transport Chain Protein Abnormalities Detected in Plasma Extracellular Vesicles in Alzheimer’s Disease

Biomedicines, 2021
Mitochondria provide energy to neurons through oxidative phosphorylation and eliminate Reactive Oxygen Species (ROS) through Superoxide Dismutase 1 (SOD1).
Pamela J. Yao, Erden Eren, Edward J. Goetzl, Dimitrios Kapogiannis   +3 more
doaj   +1 more source

Electron Transport Chain Complex II Regulates Steroid Metabolism

iScience, 2020
Summary: The first steroidogenic enzyme, cytochrome P450-side-chain-cleavage (SCC), requires electron transport chain (ETC) complexes III and IV to initiate steroid metabolic processes for mammalian survival.
Himangshu S. Bose, Brendan Marshall, Dilip K. Debnath, Elizabeth W. Perry, Randy M. Whittal   +4 more
doaj  

Astragaloside IV Inhibits Mitochondrial-Dependent Apoptosis of the Dorsal Root Ganglion in Diabetic Peripheral Neuropathy Rats Through Modulation of the SIRT1/p53 Signaling Pathway

Diabetes, Metabolic Syndrome and Obesity, 2021
Ying Ben,1,2,* Juan Hao,1,* Zhihong Zhang,1,2 Yunzhao Xiong,1 Cuijuan Zhang,1,2 Yi Chang,1,2 Fan Yang,1,2 Hui Li,1,2 Tianya Zhang,1 Xiangting Wang,1,2 Qingyou Xu1,2 1Hebei University of Chinese Medicine, Shijiazhuang, Hebei, People’s Republic of ...
Ben Y, Hao J, Zhang Z, Xiong Y, Zhang C, Chang Y, Yang F, Li H, Zhang T, Wang X, Xu Q   +10 more
doaj  

Streptozotocin-Induced Adaptive Modification of Mitochondrial Supercomplexes in Liver of Wistar Rats and the Protective Effect of Moringa oleifera Lam

Biochemistry Research International, 2018
The increasing prevalence of diabetes continues to be a major health issue worldwide. Alteration of mitochondrial electron transport chain is a recognized hallmark of the diabetic-associated decline in liver bioenergetics; however, the molecular events ...
María Alejandra Sánchez-Muñoz, Mónica Andrea Valdez-Solana, Mara Ibeth Campos-Almazán, Óscar Flores-Herrera, Mercedes Esparza-Perusquía, Sofia Olvera-Sánchez, Guadalupe García-Arenas, Claudia Avitia-Domínguez, Alfredo Téllez-Valencia, Erick Sierra-Campos   +9 more
doaj   +1 more source

Cryptococcus neoformans Mar1 function links mitochondrial metabolism, oxidative stress, and antifungal tolerance

Frontiers in Physiology, 2023
Introduction: Microbial pathogens undergo significant physiological changes during interactions with the infected host, including alterations in metabolism and cell architecture.
Calla L. Telzrow, Calla L. Telzrow, Shannon Esher Righi, Jackson M. Cathey, Joshua A. Granek, J. Andrew Alspaugh, J. Andrew Alspaugh   +6 more
doaj   +1 more source

Structural study of Topoisomerase IV-DNA-Levofloxacin complexes from Streptococcus pneumoniae [PDF]

E3S Web of Conferences, 2019
S. pneumoniae is an important pathogen causing pulmonary infection, acute otitis media and purulent meningitis in infants and children. Type II topoisomerases are enzymes that play essential roles in DNA replication, chromosome segregation and ...
Wang Xilan
doaj   +1 more source

Enhanced Skeletal Muscle Oxidative Capacity and Capillary-to-Fiber Ratio Following Moderately Increased Testosterone Exposure in Young Healthy Women

Frontiers in Physiology, 2020
Background: Recently, it was shown that exogenously administered testosterone enhances endurance capacity in women. In this study, our understanding on the effects of exogenous testosterone on key determinants of oxygen transport and utilization in ...
Daniele A. Cardinale, Daniele A. Cardinale, Oscar Horwath, Jona Elings-Knutsson, Jona Elings-Knutsson, Torbjörn Helge, Manne Godhe, Stéphane Bermon, Marcus Moberg, Mikael Flockhart, Filip J. Larsen, Angelica Lindén Hirschberg, Angelica Lindén Hirschberg, Björn Ekblom   +13 more
doaj   +1 more source