Results 41 to 50 of about 441,339 (185)

Caloric restriction reveals a metabolomic and lipidomic signature in liver of male mice [PDF]

, 2014
Lipid composition, particularly membrane unsaturation, has been proposed as being a lifespan determinant, but it is currently unknown whether caloric restriction (CR), an accepted life-extending intervention, affects cellular lipid profiles.
Jové, Mariona, Naudí, Alba, Pamplona, Reinald, Portero-Otín, Manuel, Ramírez-Núñez, Omar, Selman, Colin, Withers, Dominic J.   +6 more
core   +3 more sources

Mechanistic Target of Rapamycin Complex 1 Promotes the Expression of Genes Encoding Electron Transport Chain Proteins and Stimulates Oxidative Phosphorylation in Primary Human Trophoblast Cells by Regulating Mitochondrial Biogenesis

Scientific Reports, 2019
Trophoblast oxidative phosphorylation provides energy for active transport and protein synthesis, which are critical placental functions influencing fetal growth and long-term health.
Fredrick J Rosario, Madhulika B. Gupta, L. Myatt, T. Powell, J. Glenn, L. Cox, T. Jansson   +6 more
semanticscholar   +1 more source

Multi-heme Cytochromes in Shewanella oneidensis MR-1:Structures, functions and opportunities [PDF]

, 2015
Multi-heme cytochromes are employed by a range of microorganisms to transport electrons over distances of up to tens of nanometers. Perhaps the most spectacular utilization of these proteins is in the reduction of extracellular solid substrates ...
Brown JP, Collins MJ, Coursolle D, Fonseca BM, Jochen Blumberger, Julea N. Butt, Kevin M. Rosso, Marian Breuer, Song Y, Teixeira M   +9 more
core   +1 more source

Sordaria macrospora Sterile Mutant pro34 Is Impaired in Respiratory Complex I Assembly

Journal of Fungi, 2022
The formation of fruiting bodies is a highly regulated process that requires the coordinated formation of different cell types. By analyzing developmental mutants, many developmental factors have already been identified.
Andrea Hamann, Heinz D. Osiewacz, Ines Teichert   +2 more
doaj   +1 more source

Efficient Electron Hopping Transport through Azurin-Based Junctions

Journal of Physical Chemistry Letters, 2023
We conducted a theoretical study of electron transport through junctions of the blue-copper azurin from Pseudomonas aeruginosa. We found that single-site hopping can lead to either higher or lower current values compared to fully coherent transport. This
C. Roldán-Piñero, C. Romero-Muñiz, Ismael Díez-Pérez, J. Vilhena, R. Pérez, Juan Carlos Cuevas, L. Zotti   +6 more
semanticscholar   +1 more source

Anesthesia-Sepsis-Associated Alterations in Liver Gene Expression Profiles and Mitochondrial Oxidative Phosphorylation Complexes

Frontiers in Medicine, 2020
Background: Hepatic dysfunction plays a major role in adverse outcomes in sepsis. Volatile anesthetic agents may protect against organ dysfunction in the setting of critical illness and infection.
Hari Prasad Osuru, Umadevi Paila, Keita Ikeda, Zhiyi Zuo, Robert H. Thiele   +4 more
doaj   +1 more source

High-level inhibition of mitochondrial complexes III and IV is required to increase glutamate release from the nerve terminal

Molecular Neurodegeneration, 2011
Background The activities of mitochondrial complex III (ubiquinol-cytochrome c reductase, EC 1.10.2.2) and complex IV (cytochrome c oxidase EC 1.9.3.1) are reduced by 30-70% in Huntington's disease and Alzheimer's disease, respectively, and are ...
Kilbride Seán M, Gluchowska Sonia A, Telford Jayne E, O'Sullivan Catherine, Davey Gavin P   +4 more
doaj   +1 more source

Differential requirements for mitochondrial electron transport chain components in the adult murine liver

eLife, 2022
Mitochondrial electron transport chain (ETC) dysfunction due to mutations in the nuclear or mitochondrial genome is a common cause of metabolic disease in humans and displays striking tissue specificity depending on the affected gene.
Nicholas P Lesner, Xun Wang, Zhenkang Chen, Anderson Frank, Cameron J Menezes, Sara House, Spencer D Shelton, Andrew Lemoff, David G McFadden, Janaka Wansapura, Ralph J DeBerardinis, Prashant Mishra   +11 more
doaj   +1 more source

Assessment of the Maximal Activity of Complex IV in the Inner Mitochondrial Membrane by Tandem Electrochemistry and Respirometry.

Analytical Chemistry, 2020
Assessment of activities of mitochondrial electron transport enzymes is important for understanding mechanisms of metabolic diseases, but structural organization of mitochondria and low sample availability pose distinctive challenges for in situ ...
Nathan L Frantz, Gabrielle Brakoniecki, Dawei Chen, D. Proshlyakov   +3 more
semanticscholar   +1 more source

Mechanisms of Bacterial Extracellular Electron Exchange. [PDF]

, 2016
The biochemical mechanisms by which microbes interact with extracellular soluble metal ions and insoluble redox-active minerals have been the focus of intense research over the last three decades. The process presents two challenges to the microorganism;
Butt, Julea N., Clarke, Thomas A., Edwards, Marcus J., Gomez-Perez, Laura, Richardson, David J., White, Gaye F.   +5 more
core   +1 more source