Results 81 to 90 of about 2,688,547 (318)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Antimicrobial susceptibility of clinical isolates of Stenotrophomonas maltophilia isolates from Europe, Asia, and Latin America (2018-2023)

International Journal of Infectious Diseases
Background: The occurrence of Stenotrophomonas maltophilia infections, especially pneumonia, has increased consistently in the last years. We evaluated the antimicrobial susceptibility of a large collection of S.
Helio S. Sader, Rodrigo E. Mendes, Timothy B. Doyle, Marisa L. Winkler, Mariana Castanheira   +4 more
doaj   +1 more source

Discovery of hexagonal ternary phase Ti2InB2 and its evolution to layered boride TiB

Nature Communications, 2019
Two-dimensional materials are promising for electrochemical storage and conversion, but are somewhat limited in composition. Here the authors use a computational strategy to predict the existence of a layered boride material, which they synthesize and ...
Junjie Wang, Tian-Nan Ye, Yutong Gong, Jiazhen Wu, Nanxi Miao, Tomofumi Tada, Hideo Hosono   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Characterization of sulopenem antimicrobial activity using in vitro time-kill kinetics, synergy, post-antibiotic effect, and sub-inhibitory MIC effect methods against Escherichia coli and Klebsiella pneumoniae isolates

Microbiology Spectrum
Sulopenem is an oral and intravenous penem antibiotic in clinical development for treatment of urinary tract and intra-abdominal infections caused by multidrug-resistant pathogens. This study evaluated in vitro antimicrobial activity of sulopenem by post-
Joshua M. Maher, Michael D. Huband, Jill M. Lindley, Paul R. Rhomberg, Steven I. Aronin, Sailaja Puttagunta, Mariana Castanheira   +6 more
doaj   +1 more source

Palladium-bearing intermetallic electride as an efficient and stable catalyst for Suzuki cross-coupling reactions

Nature Communications, 2019
In Suzuki coupling reactions, excellent catalytic performance require negatively charged Pd species and the avoidance of metal leaching or clustering.
Tian-Nan Ye, Yangfan Lu, Zewen Xiao, Jiang Li, Takuya Nakao, Hitoshi Abe, Yasuhiro Niwa, Masaaki Kitano, Tomofumi Tada, Hideo Hosono   +9 more
doaj   +1 more source

A two-level enriched finite element method for a mixed problem

, 2011
The simplest pair of spaces is made inf-sup stable for the mixed form of the Darcy equation. The key ingredient is to enhance the finite element spaces inside a Petrov-Galerkin framework with functions satisfying element-wise local Darcy problems with ...
Barrenechea, Gabriel, Hernández, Erwin, Allendes Flores, Alejandro Ignacio, Valentin, Frédéric   +3 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Acoustic displacement triangle based on the individual element test

, 2012
A three node, displacement based, acoustic element is developed. In order to avoid spurious rotational modes, a higher order stiffness is introduced. The higher order stiffness is developed from an incompatible strain field which computes element volume ...
Correa, S., Militello, C., Recuero López, Manuel   +2 more
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source