Results 1 to 10 of about 15,439,652 (357)

NF-κB activation impedes the transdifferentiation of hypertrophic chondrocytes at the growth plate of mouse embryos in diabetic pregnancy

Journal of Orthopaedic Translation, 2021
Background: Diabetes mellitus could cause numerous complications and health problems including abnormality of endochondral bone formation during embryogenesis. However, the underlying mechanisms still remain obscure.
Xi Liu, Fan Qian, Qiwei Fan, Li Lin, Meiyao He, Peizhi Li, Hongmei Cai, Lisha Ma, Xin Cheng, Xuesong Yang   +9 more
doaj   +1 more source

CXCL5 Downregulation in Villous Tissue Is Correlated With Recurrent Spontaneous Abortion

Frontiers in Immunology, 2021
Recurrent spontaneous abortion (RSA) affects 5% of childbearing-age women worldwide. Inadequate trophoblast invasion is one of the main reasons for the development of RSA; however, the underlying molecular mechanisms for RSA have not been fully ...
Sainan Zhang, Jinli Ding, Jiayu Wang, Tailang Yin, Yan Zhang, Jing Yang   +5 more
doaj   +1 more source

USP25 Regulates the Proliferation and Apoptosis of Ovarian Granulosa Cells in Polycystic Ovary Syndrome by Modulating the PI3K/AKT Pathway via Deubiquitinating PTEN

Frontiers in Cell and Developmental Biology, 2021
Background: Polycystic ovarian syndrome (PCOS) is an endocrine-related disease related to abnormal folliculogenesis and is a leading cause of infertility worldwide.
Yue Gao, Jiao Chen, Rui Ji, Jinli Ding, Yan Zhang, Jing Yang   +5 more
doaj   +1 more source

Mitochondrial contributions to oocyte and embryonic quality in bovine [PDF]

SPERMOVA, 2017
Mitochondria are powerhouse organelles involved in several vital functions in cells, mainly maintaining balance between ATP synthesis and oxidative stress during early development in mammalian embryos.
Baldoceda L, Robert C
doaj   +1 more source

Retinoic Acid Signaling Plays a Crucial Role in Excessive Caffeine Intake-Disturbed Apoptosis and Differentiation of Myogenic Progenitors

Frontiers in Cell and Developmental Biology, 2021
Whether or not the process of somitogenesis and myogenesis is affected by excessive caffeine intake still remains ambiguous. In this study, we first showed that caffeine treatment results in chest wall deformities and simultaneously reduced mRNA ...
Nian Wu, Nian Wu, Yingshi Li, Xiangyue He, Xiangyue He, Jiayi Lin, Denglu Long, Xin Cheng, Beate Brand-Saberi, Guang Wang, Guang Wang, Xuesong Yang, Xuesong Yang   +12 more
doaj   +1 more source

Oviductal regulation of fertilization and early embryonic development.

Journal of reproduction and fertility. Supplement, 2020
During the period of late follicular development and the first four days of the oestrous cycle, the oviduct occupies a central role in the establishment of pregnancy.
W. Buhi, I. M. Alvarez, Andrew J. Kouba
semanticscholar   +1 more source

The role of oxygen availability in embryonic development and stem cell function

Nature Reviews Molecular Cell Biology, 2008
M Celeste Simon
exaly   +2 more sources

Nanocomposites based on nanoceria regulate the immune microenvironment for the treatment of polycystic ovary syndrome

Journal of Nanobiotechnology, 2023
The immune system is closely associated with the pathogenesis of polycystic ovary syndrome (PCOS). Macrophages are one of the important immune cell types in the ovarian proinflammatory microenvironment, and ameliorate the inflammatory status mainly ...
Sisi Yan, Zhipeng Gao, Jinli Ding, Suming Chen, Zehao Wang, Wenyi Jin, Bing Qu, Yi Zhang, Lian Yang, Duanying Guo, Tailang Yin, Yanbing Yang, Yan Zhang, Jing Yang   +13 more
doaj   +1 more source

Non-Coding RNAs Regulate Placental Trophoblast Function and Participate in Recurrent Abortion

Frontiers in Pharmacology, 2021
Recurrent spontaneous abortion (RSA) is a serious pregnancy complication with an increasing clinical incidence. The various causes of recurrent abortion are complicated.
Xin Chen, Duan-Ying Guo, Tai-Lang Yin, Jing Yang   +3 more
doaj   +1 more source

Global Gene Expression Profiling of Individual Human Oocytes and Embryos Demonstrates Heterogeneity in Early Development [PDF]

, 2013
Early development in humans is characterised by low and variable embryonic viability, reflected in low fecundity and high rates of miscarriage, relative to other mammals.
Brison, Daniel R., Kimber, Susan J., Shaw, Lisa, Sneddon, Sharon F., Zeef, Leo   +4 more
core   +13 more sources