Results 1 to 10 of about 759,470 (167)

The role of spatial averaging in the precision of gene expression patterns [PDF]

, 2009
During embryonic development, differentiating cells respond via gene expression to positional cues from morphogen gradients. While gene expression is often highly erratic, embryonic development is precise. We show by theory and simulations that diffusion of the expressed protein can enhance the precision of its expression domain.
Erdmann, Thorsten, Howard, Martin, Wolde, Pieter Rein ten   +2 more
arxiv   +4 more sources

CXCL5 Downregulation in Villous Tissue Is Correlated With Recurrent Spontaneous Abortion

Frontiers in Immunology, 2021
Recurrent spontaneous abortion (RSA) affects 5% of childbearing-age women worldwide. Inadequate trophoblast invasion is one of the main reasons for the development of RSA; however, the underlying molecular mechanisms for RSA have not been fully ...
Sainan Zhang, Jinli Ding, Jiayu Wang, Tailang Yin, Yan Zhang, Jing Yang   +5 more
doaj   +1 more source

USP25 Regulates the Proliferation and Apoptosis of Ovarian Granulosa Cells in Polycystic Ovary Syndrome by Modulating the PI3K/AKT Pathway via Deubiquitinating PTEN

Frontiers in Cell and Developmental Biology, 2021
Background: Polycystic ovarian syndrome (PCOS) is an endocrine-related disease related to abnormal folliculogenesis and is a leading cause of infertility worldwide.
Yue Gao, Jiao Chen, Rui Ji, Jinli Ding, Yan Zhang, Jing Yang   +5 more
doaj   +1 more source

Retinoic Acid Signaling Plays a Crucial Role in Excessive Caffeine Intake-Disturbed Apoptosis and Differentiation of Myogenic Progenitors

Frontiers in Cell and Developmental Biology, 2021
Whether or not the process of somitogenesis and myogenesis is affected by excessive caffeine intake still remains ambiguous. In this study, we first showed that caffeine treatment results in chest wall deformities and simultaneously reduced mRNA ...
Nian Wu, Nian Wu, Yingshi Li, Xiangyue He, Xiangyue He, Jiayi Lin, Denglu Long, Xin Cheng, Beate Brand-Saberi, Guang Wang, Guang Wang, Xuesong Yang, Xuesong Yang   +12 more
doaj   +1 more source

Mitochondrial contributions to oocyte and embryonic quality in bovine [PDF]

SPERMOVA, 2017
Mitochondria are powerhouse organelles involved in several vital functions in cells, mainly maintaining balance between ATP synthesis and oxidative stress during early development in mammalian embryos.
Baldoceda L, Robert C
doaj   +1 more source

Mechanical Plasticity of Cell Membranes Enhances Epithelial Wound Closure [PDF]

Phys.Rev.Research. 6 (2024) L012036, 2023
During epithelial wound healing, cell morphology near the healed wound and the healing rate vary strongly among different developmental stages even for a single species like \textit{Drosophila}. We develop deformable particle (DP) model simulations to understand how variations in cell mechanics give rise to distinct wound closure phenotypes in the ...
arxiv   +1 more source

Non-Coding RNAs Regulate Placental Trophoblast Function and Participate in Recurrent Abortion

Frontiers in Pharmacology, 2021
Recurrent spontaneous abortion (RSA) is a serious pregnancy complication with an increasing clinical incidence. The various causes of recurrent abortion are complicated.
Xin Chen, Duan-Ying Guo, Tai-Lang Yin, Jing Yang   +3 more
doaj   +1 more source

Nanocomposites based on nanoceria regulate the immune microenvironment for the treatment of polycystic ovary syndrome

Journal of Nanobiotechnology, 2023
The immune system is closely associated with the pathogenesis of polycystic ovary syndrome (PCOS). Macrophages are one of the important immune cell types in the ovarian proinflammatory microenvironment, and ameliorate the inflammatory status mainly ...
Sisi Yan, Zhipeng Gao, Jinli Ding, Suming Chen, Zehao Wang, Wenyi Jin, Bing Qu, Yi Zhang, Lian Yang, Duanying Guo, Tailang Yin, Yanbing Yang, Yan Zhang, Jing Yang   +13 more
doaj   +1 more source

Maternal and infant outcomes during the COVID-19 pandemic: a retrospective study in Guangzhou, China

Reproductive Biology and Endocrinology, 2021
In late December 2019, the COVID-19 pandemic caused a great threat to people’s lives worldwide. As a special category of the population, pregnant women are vulnerable during emergencies.
Jingyun Wang, Yun Wang, Mei-yao He, Yi-xiao Li, Xin Cheng, Xuesong Yang, Rui-man Li, Guang Wang   +7 more
doaj   +1 more source

Regulation and Function of Chemokines at the Maternal–Fetal Interface

Frontiers in Cell and Developmental Biology, 2022
Successful pregnancy requires the maternal immune system to tolerate the semi-allogeneic embryo. A good trophoblast function is also essential for successful embryo implantation and subsequent placental development.
Sainan Zhang, Jinli Ding, Yan Zhang, Su Liu, Jing Yang, Tailang Yin   +5 more
doaj   +1 more source