Results 11 to 20 of about 1,228,315 (316)

The Conceivable Functions of Protein Ubiquitination and Deubiquitination in Reproduction

Frontiers in Physiology, 2022
Protein ubiquitination with general existence in virtually all eukaryotic cells serves as a significant post-translational modification of cellular proteins, which leads to the degradation of proteins via the ubiquitin–proteasome system. Deubiquitinating
Jiayu Wang, Jiayu Wang, Qi Zhou, Qi Zhou, Jinli Ding, Jinli Ding, Tailang Yin, Tailang Yin, Peng Ye, Yan Zhang, Yan Zhang   +10 more
doaj   +1 more source

Mechano-biochemical marine stimulation of inversion, gastrulation, and endomesoderm specification in multicellular Eukaryota

Frontiers in Cell and Developmental Biology, 2022
The evolutionary emergence of the primitive gut in Metazoa is one of the decisive events that conditioned the major evolutionary transition, leading to the origin of animal development.
Ngoc Minh Nguyen, Tatiana Merle, Florence Broders-Bondon, Anne-Christine Brunet, Aude Battistella, Emelie Britt Linnea Land, Florian Sarron, Aditya Jha, Jean-Luc Gennisson, Eric Röttinger, Eric Röttinger, María Elena Fernández-Sánchez, Emmanuel Farge   +12 more
doaj   +1 more source

TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors. [PDF]

, 2015
The genomic regulatory programmes that underlie human organogenesis are poorly understood. Pancreas development, in particular, has pivotal implications for pancreatic regeneration, cancer and diabetes.
A Kapoor, A Krapp, A Rada-Iglesias, A Sawada, A-C Binot, AF Hezel, AJ Saldanha, B Zhao, B Zhao, C Cortijo, C Haumaitre, C Trapnell, CHH Cho, CY McLean, DA Stoffers, DW Huang, E Kroon, E Rodríguez-Seguel, EF Chiang, F Argenton, F Esni, F Supek, FC Lynn, FC Pan, H Fang, H Fang, H Lango Allen, I Morán, I Rooman, J Bessa, J van Arensbergen, JM Oliver-Krasinski, K Kawakami, K Piper, K Piper, K Skouloudaki, KJ Gaulton, KM Petzold, KS Zaret, L Elghazi, L Pasquali, M Borowiak, M Carrasco, M Gannon, MA Maestro, MC Whitlock, MF Offield, MJL de Hoon, MN Weedon, MP Creyghton, N Bardeesy, N Gao, NM George, P Jacquemin, PA Seymour, R O’Rahilly, R Xie, RE Jennings, RF Luco, S Gupta, S Heinz, S Xuan, T Derrien, T Jowett, W Zhang, WA Whyte, Y Fujitani, Y Liu-Chittenden   +67 more
core   +2 more sources

Ret kinase-mediated mechanical induction of colon stem cells by tumor growth pressure stimulates cancer progression in vivo

Communications Biology, 2022
Ho-Bouldoires, Sollier, Zamfirov and Broders-Bondon et al. show that high frequency pulsatile mechanical stresses maintain the physiological level of mice colon stem cells through the mechanosensitive Ret kinase and that Ret activation is elevated in ...
Thanh Huong Nguyen Ho-Bouldoires, Kévin Sollier, Laura Zamfirov, Florence Broders-Bondon, Démosthène Mitrossilis, Sebastian Bermeo, Coralie L. Guerin, Anna Chipont, Gabriel Champenois, Renaud Leclère, Nicolas André, Laurent Ranno, Aude Michel, Christine Ménager, Didier Meseure, Charlie Demené, Mickael Tanter, Maria Elena Fernández-Sánchez, Emmanuel Farge   +18 more
doaj   +1 more source

Muc5ac mucin expression during rat skin development [PDF]

, 2015
Some mucin genes have been detected during human embryonic and fetal organ development; however, little is known about mucin expression in epidermal development, neither in humans nor in other species. The present research was developed to explore Muc5ac
Barbeito, Claudio Gustavo, Croce, María Virginia, Ferretti, Valeria, Segal Eiras, Amada   +3 more
core   +2 more sources

Identification of novel chondroitin proteoglycans in Caenorhabditis elegans: embryonic cell division depends on CPG-1 and CPG-2. [PDF]

, 2006
Vertebrates produce multiple chondroitin sulfate proteoglycans that play important roles in development and tissue mechanics. In the nematode Caenorhabditis elegans, the chondroitin chains lack sulfate but nevertheless play essential roles in embryonic ...
Bishop, Joseph R, Esko, Jeffrey D, Oegema, Karen, Olson, Sara K, Yates, John R   +4 more
core   +2 more sources

Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors

Nature Communications, 2018
A role for Slit/Robo signalling in pancreas development has not been defined. Here, the authors generate Robo1/Robo2 knockout mice to identify both as needed for establishing initial pancreatic cell identity as well as for proliferation and survival of ...
Sophie Escot, David Willnow, Heike Naumann, Silvia Di Francescantonio, Francesca M. Spagnoli   +4 more
doaj   +1 more source

The Mechanism of Pattern Transitions between Formation and Dispersion [PDF]

Journal of Theoretical Biology. 581, 111736 (2024), 2023
The patterns observed on the body surface of living organisms have traditionally been attributed solely to ecological strategies. However, this study investigates a fascinating phenomenon in Pelodiscus sinensis, where patterns formed on the plastron during embryonic and juvenile stages, which are not externally visible, ultimately disappear in ...
arxiv   +1 more source

Effects of pregnancy on neuromyelitis optica spectrum disorder and predictors of related attacks

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1918-1925, December 2022., 2022
Abstract Objective Our study aimed to investigate the influence of pregnancy on the course of neuromyelitis optica spectrum disorders (NMOSD) and to explore the independent predictors of pregnancy‐related attacks. Methods We performed a retrospective study of patients with NMOSD based on the Wingerchuk 2006 or the revised Wingerchuk 2015 criteria ...
Qin Du, Ziyan Shi, Hongxi Chen, Ying Zhang, Yuhan Qiu, Yanlin Lang, Lingyao Kong, Hongyu Zhou   +7 more
wiley   +1 more source

Brain magnetic resonance imaging predictors in anti‐N‐methyl‐D‐aspartate receptor encephalitis

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1974-1984, December 2022., 2022
Abstract Objective Brain magnetic resonance imaging (MRI) findings in anti‐N‐methyl‐D‐aspartate receptor (NMDAR) encephalitis are nonspecific and rarely have obvious associations with clinical characteristics and outcomes. This study aimed to comprehensively describe the MRI features of patients with NMDAR encephalitis, examine their associations with ...
Ying‐Ying Zhao, Bing Han, Cui‐Hong Qin, Xue‐Xiu Shi, Wen‐Jing Yun, Meng Wang, Bo Yuan, Tong‐Wen Sun, Hai‐Xu Wang   +8 more
wiley   +1 more source