Results 71 to 80 of about 1,153,497 (356)

Phosphoproteomics identifies a bimodal EPHA2 receptor switch that promotes embryonic stem cell differentiation [PDF]

, 2020
Embryonic Stem Cell (ESC) differentiation requires complex cell signalling network dynamics, although the key molecular events remain poorly understood.
Budzyk, Manon, Bustos, Francisco, Fernandez-Alonso, Rosalia, Findlay, Greg M., Helbig, Andreas O., Hukelmann, Jens, Kumar, Pankaj, Lamond, Angus I., Lanner, Fredrik, Petsalaki, Evangelia, Zhou, Houjiang   +10 more
core   +2 more sources

Mechanisms of embryonic stomach development [PDF]

Seminars in Cell & Developmental Biology, 2017
The stomach is a digestive organ that has important roles in human physiology and pathophysiology. The developmental origin of the stomach is the embryonic foregut, which also gives rise a number of other structures. There are several signaling pathways and transcription factors that are known to regulate stomach development at different stages ...
Kyle W, McCracken, James M, Wells
openaire   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Association between mental health and male fertility: depression, rather than anxiety, is linked to decreased semen quality

Frontiers in Endocrinology
BackgroundInfertility is increasingly recognized as a global health issue affecting couples of reproductive age, with male factors contributing to approximately 50% of infertility cases.
Yi Zhang, Yi Zhang, Bei Chen, Bei Chen, Yaqin Wang, Yaqin Wang, Cong Liu, Cong Liu, Jiayi Sun, Jiayi Sun, Zhimo Zhang, Zhimo Zhang, Liangzi Guan, Liangzi Guan, Ke Xiao, Ke Xiao, Ke Xiao, Zhonghai Zhu, Jin Luo, Jin Luo   +19 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

The major β-catenin/E-cadherin junctional binding site is a primary molecular mechano-transductor of differentiation in vivo

eLife, 2018
In vivo, the primary molecular mechanotransductive events mechanically initiating cell differentiation remain unknown. Here we find the molecular stretching of the highly conserved Y654-β-catenin-D665-E-cadherin binding site as mechanically induced by ...
Jens-Christian Röper, Démosthène Mitrossilis, Guillaume Stirnemann, François Waharte, Isabel Brito, Maria-Elena Fernandez-Sanchez, Marc Baaden, Jean Salamero, Emmanuel Farge   +8 more
doaj   +1 more source

International cooperation and the challenge of internet accessibility in Caribbean territories: example of a collaborative platform between the University Hospital of Martinique and Ramón González Coro Hospital in Cuba, through the French PRPH-3 program

BMC Medical Education, 2023
Background Martinique shares with the other Caribbean countries specific public health issues, particularly in the diagnostic and therapeutic management of cancer patients.
Rémi Houpert, Thierry Almont, Christian Mésenge, Line Kleinebreil, Laurence Forlini, Bruno Magnone, Vincent Leroux, Mylène Vestris, Christelle Montabord, Jaylin Carmenate, Yaima Galán, Maria Caredad Rubio, Rodolfo Enriquez, Carol Burte, Nicolas Gatimel, Louis Bujan, Norelyakin Kara, Olivier Edwige, Éric Huyghe, Clarisse Joachim, Jacqueline Véronique-Baudin   +20 more
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Analysis of factors associated with IVF/ICSI clinical outcomes in advanced maternal age patients with normal ovarian reserve under the POSEIDON criteria

Frontiers in Endocrinology
BackgroundThere is limited research about the pregnancy outcomes of POSEIDON group 2 patients. This study aims to evaluate the factors related to the clinical outcomes of in vitro fertilization (IVF) and/or intracytoplasmic sperm injection (ICSI) in ...
Yicen Meng, Yicen Meng, Yicen Meng, Qianjie Zhang, Qianjie Zhang, Qianjie Zhang, Yixuan Song, Yixuan Song, Yixuan Song, Qian Liu, Qian Liu, Qian Liu, Wei Li, Jing Yang, Jing Yang, Saijiao Li, Saijiao Li   +16 more
doaj   +1 more source

Mechanotransductive cascade of Myo-II-dependent mesoderm and endoderm invaginations in embryo gastrulation

Nature Communications, 2017
Mechanical signals regulate tissue differentiation but how this triggers downstream biochemical signals is unclear. Here, the authors place micro-magnets in theDrosophilaembryonic epithelia and show this triggers apical pulsations, in turn stabilizing ...
Démosthène Mitrossilis, Jens-Christian Röper, Damien Le Roy, Benjamin Driquez, Aude Michel, Christine Ménager, Gorky Shaw, Simon Le Denmat, Laurent Ranno, Frédéric Dumas-Bouchiat, Nora M. Dempsey, Emmanuel Farge   +11 more
doaj   +1 more source