Results 11 to 20 of about 1,293,017 (382)

Subventricular zone stem cells are heterogeneous with respect to their embryonic origins and neurogenic fates in the adult olfactory bulb [PDF]

, 2007
Wedetermined the embryonic origins of adult forebrain subventricular zone (SVZ) stem cells by Cre-lox fate mapping in transgenic mice. We found that all parts of the telencephalic neuroepithelium, including the medial ganglionic eminence and lateral ...
C.H. Papadimitriou, D. Eppstein, D.D. Sleator, D.E. Knuth, K.M. Lillis, P. Angelini, R. Dhandapani, R.B. Muhammad, T. Leighton   +8 more
core   +4 more sources

Spatio-temporal model of Meox1 expression control involvement of Sca-1-positive stem cells in neointima formation through the synergistic effect of Rho/CDC42 and SDF-1α/CXCR4

Stem Cell Research & Therapy, 2021
Aims Neointimal hyperplasia remains a major obstacle in vascular regeneration. Sca-1-positive progenitor cells residing within the vascular adventitia play a crucial role in the assemblage of vascular smooth muscle cell (VSMC) and the formation of the ...
Yan Wu, Yuan-jin Li, Liu-liu Shi, Yun Liu, Yan Wang, Xin Bao, Wei Xu, Lu-yuan Yao, Magdaleena Naemi Mbadhi, Long Chen, Shan Li, Xing-yuan Li, Zhi-feng Zhang, Sen Zhao, Ruo-nan Zhang, Shi-You Chen, Jing-xuan Zhang, Jun-mingTang   +17 more
doaj   +1 more source

Qiliqiangxin reduced cardiomyocytes apotosis and improved heart function in infarcted heart through Pink1/Parkin -mediated mitochondrial autophagy

BMC Complementary Medicine and Therapies, 2020
Background Qiliqiangxin (QLQX) is a preparation refined from a traditional Chinese medicine compound. It plays an important role in protecting cardiac function after myocardial infarction (MI). However, the underline mechanism of QLQX action is not clear.
Junyang Zhou, Zhixiao Wang, Yun He, Xinxia Luo, Wenjun Zhang, Li Yu, Xiuying Chen, Xiju He, Yahong Yuan, Xiaoli Wang, Xinrong Guo, Junming Tang, Mingan Zhu, Dongsheng Li, Yan Ding   +14 more
doaj   +1 more source

An Efficient and Footprint-Free Protocol for the Transdifferentiation of Hepatocytes Into Insulin-Producing Cells With IVT mRNAs

Frontiers in Genetics, 2020
BackgroundDirect transdifferentiation of adult somatic cells into insulin-producing cells (IPCs) is a promising approach for cell-based therapies for type 1 diabetes mellitus.
Shinan Ma, Mengjie Yang, Mengjie Yang, Wenhui Zhou, Longjun Dai, Longjun Dai, Yan Ding, Xingrong Guo, Yahong Yuan, Junming Tang, Dongsheng Li, Xiaoli Wang   +11 more
doaj   +1 more source

Chicken embryonic stem cells as a non‐mammalian embryonic stem cell model [PDF]

Development, Growth & Differentiation, 2010
Embryonic stem cells (ESCs) were isolated in the early 1980s from mouse and in the late 1990s from primate and human. These cells present the unique property of self‐renewal and the ability to generate differentiated progeny in all embryonic lineages both in vitro and in vivo.
Fabrice Lavial, Bertrand Pain, Bertrand Pain   +2 more
openaire   +6 more sources

Generation of C57BL/6 knockout mice using C3H × BALB/c blastocysts

BioTechniques, 2008
The International Mouse Knockout Consortium aims to generate a knockout mouse for every single gene on a C57BL/6 background. Our ability to generate such mice is hampered by the poor economics of producing blastocysts to achieve germline transmission of ...
Gabriela Pacholczyk, Rupali Suhag, Magdalena Mazurek, Suzanne M. Dederscheck, Pandelakis A. Koni   +4 more
doaj   +1 more source

ANGPTL8 promotes adipogenic differentiation of mesenchymal stem cells: potential role in ectopic lipid deposition

Frontiers in Endocrinology, 2022
BackgroundEctopic lipid deposition plays a promoting role in many chronic metabolic diseases. Abnormal adipogenic differentiation of mesenchymal stem cells (MSCs) is an important cause of lipid deposition in organs.
Jian Tang, Jian Tang, Shinan Ma, Yujiu Gao, Fan Zeng, Ying Feng, Chong Guo, Lin Hu, Lingling Yang, Lingling Yang, Yanghui Chen, Qiufang Zhang, Yahong Yuan, Xingrong Guo, Xingrong Guo   +14 more
doaj   +1 more source

Proton MR Spectroscopy of Neural Stem Cells: Does the Proton-NMR Peak at 1.28 ppm Function As a Biomarker for Cell Type or State? [PDF]

, 2011
Recently, a peak at 1.28 ppm in proton magnetic resonance spectroscopy (^1H-MRS) of neural stem cells (NSCs) was introduced as a noninterventional biomarker for neurogenesis in vivo. This would be an urgently needed requisite for translational studies in
Brandt, Moritz, Fuchs, Beate, Hermann, Andreas, Kirsch, Matthias, Loewenbrück, Kai F., Schiller, Jürgen, Schwarz, Johannes, Schwarz, Sigrid, Storch, Alexander, Werner, Annett   +9 more
core   +1 more source

In vitro human embryonic stem cell hematopoiesis mimics MYB-independent yolk sac hematopoiesis [PDF]

, 2014
Although hematopoietic precursor activity can be generated in vitro from human embryonic stem cells, there is no solid evidence for the appearance of multipotent, self-renewing and transplantable hematopoietic stem cells.
De Bleser, Dominique, De Mulder, Katrien, Kerre, Tessa, Lambrecht, Bart, Leclercq, Georges, Menten, Björn, Philippé, Jan, Taghon, Tom, Van Caeneghem, Yasmine, Van Roy, Nadine, Vandekerckhove, Bart, Vanhee, Stijn, Velghe, Imke, Verstichel, Greet   +13 more
core   +3 more sources

ANGPTL8 is a negative regulator in pathological cardiac hypertrophy

Cell Death and Disease, 2022
Pathological cardiac hypertrophy is an independent risk factor for heart failure and is considered a target for the treatment of heart failure. However, the mechanisms underlying pathological cardiac hypertrophy remain largely unknown.
Lin Hu, Jiarui Wei, Yue Zhang, Ziyuan Wang, Junming Tang, Jian Tang, Yujiu Gao, Xiaoqiao Zhang, Yifan Li, Yantong Liu, Shinan Ma, Xingrong Guo, Qiufang Zhang   +12 more
doaj   +1 more source