Results 91 to 100 of about 565,140 (354)
Constraints to Progress in Embryonic Stem Cells from Domestic Species [PDF]
, 2013 Domestic animal embryonic stem cells are of potentially big value in transgenic research and studies of lineage commitment and development. Unfortunately, despite many efforts, validated embryonic stem cell lines in species other than mice and primates ...
Caamaño, J.N. (José) +5 more
core
Embryonic stem cell-derived hematopoietic stem cells [PDF]
Proceedings of the National Academy of Sciences, 2005 Despite two decades of studies documenting thein vitroblood-forming potential of murine embryonic stem cells (ESCs), achieving stable long-term blood engraftment of ESC-derived hematopoietic stem cells in irradiated mice has proven difficult. We have exploited theCdx-Hoxpathway, a genetic program important for blood development, to enhance the ...
Yuan, Wang +4 more
openaire +2 more sources
Engineering the Link: From Genome Interaction Maps to Functional Insight
Advanced Biology, EarlyView.Advances in chromosome conformation capture have revealed the genome's 3D organization, yet its causal impact on gene regulation remains elusive. This review highlights emerging genome‐engineering tools ‐ zinc fingers, TALEs, and CRISPR‐Cas9 ‐ that enable targeted manipulation of chromatin loops to dissect structure–function relationships. It discusses
Frido Petersen +5 more
wiley +1 more source
PLoS ONE, 2014 This study assesses changes in activator and repressor modifications to histones associated with the core transcription factor genes most highly upregulated or downregulated in pancreatic β-cells relative to expression in an embryonic stem cell line ...
Jennifer C Y Wong +3 more
doaj +1 more source
Advanced Functional Materials, EarlyView.A biofabricated 3D in vitro model recapitulating endochondral ossification (ECO) is described, mimicking the steps from condensation to chondrogenesis and hypertrophy, culminating with vascularization of the hypertrophic construct. As a model proof of concept application, Ewing Sarcoma cells are seeded in the model, showing modifications in their ...
Maria Vittoria Colombo +13 more
wiley +1 more source
Journal of Translational Medicine, 2011 In mid November the biopharma industry was shocked by the announcement from Geron that they were ending work on embryonic stem cell research and therapy.
Ichim Thomas +2 more
doaj +1 more source
Signalling, cell cycle and pluripotency in embryonic stem cells [PDF]
, 2002 International ...
Burdon, Tom +2 more
core +1 more source
Advanced Functional Materials, EarlyView.Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana +2 more
wiley +1 more source
Pig Pluripotent Stem Cells as a Candidate for Biomedical Application
Journal of Animal Reproduction and Biotechnology, 2019 Stem cells are progenitor cells that are capable of self-renewal and differentiation into various cells. Especially, pluripotent stem cells (PSCs) have in vivo and in vitro differentiation capacity into three germ layers and can proliferate infinitely ...
Kwang-Hwan Choi, Chang-Kyu Lee
doaj +1 more source
, 2016 Background: Knowledge of the intrinsic properties of embryonic stem cells is essential before the possibility of using these cells for therapeutic purposes becomes a reality. Insertional mutagenesis screens are widely used to identify genes sufficient to
Lee, Sung-Hun, Rangasamy, Danny
core +1 more source