Results 161 to 170 of about 1,274,889 (380)

Roles of Kdm6a and Kdm6b in Regulation of Mammalian Neural Regeneration

Advanced Science, EarlyView.
This study reveals that Kdm6a plays key roles in repressing either peripheral nervous system (PNS) or central nervous system (CNS) axon regeneration, whereas Kdm6b is not involved in regulating CNS axon regeneration. Moreover, both demethylases are able to regulate CNS neuronal survival after injury, but with non‐overlapping mechanisms.
Shu‐Guang Yang, Chang‐Ping Li, Xue‐Wei Wang, Tao Huang, Cheng Qian, Qiao Li, Ling‐Rui Zhao, Si‐Yu Zhou, Chen‐Yun Ding, Rui Nie, Saijilafu, Yu‐Cai Hong, Chang‐Mei Liu, Feng‐Quan Zhou   +13 more
wiley   +1 more source

The Problem of Embryonic Stem Cell Research

Acta Medica Martiniana
Germany is quite restrictive regarding the importation and utilization of embryonic stem cells. To control stem cell research in Germany the Federal Government established in 2002 a Central Ethics Commission on Stem Cell Research.
Hans Schwarz
doaj   +1 more source

Functional Expression Cloning of Nanog, a Pluripotency Sustaining Factor in Embryonic Stem Cells

Cell, 2003
I. Chambers, Douglas Colby, M. Robertson, J. Nichols, Sonia A Lee, S. Tweedie, Austin G Smith   +6 more
semanticscholar   +1 more source

Advances in Microfluidic Cochlea‐On‐A‐Chip

Advanced Science, EarlyView.
This review systematically examines diverse cell sources for inner ear organoids and outlines stepwise induction protocols. Furthermore, it discusses current applications and prospective developments of cochlea‐on‐a‐chip technologies in areas such as deafness modeling, mechanistic studies, and drug evaluation, with particular focus on gene‐therapy drug
Tian Shen, Shanying Han, Weiwei He, Wen Yang, Xinghua Tang, Xiaolong Zhao, Xinghong Liu, Zhenhua Shao, Lin Cheng, Yu Zhao, Jiangang Fan   +10 more
wiley   +1 more source

Distinct molecular profile and restricted stem cell potential defines the prospective human cranial neural crest from embryonic stem cell state

Stem Cell Research, 2020
Neural crest cells are an embryonic multipotent stem cell population. Recent studies in model organisms have suggested that neural crest cells are specified earlier than previously thought, at blastula stages.
Maneeshi S. Prasad, Rebekah M. Charney, Lipsa J. Patel, Martín I. García-Castro   +3 more
doaj  

The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition. [PDF]

, 2015
For nearly a century developmental biologists have recognized that cells from embryos can differ in their potential to differentiate into distinct cell types.
Battle, Stephanie L, Bielas, Jason H, Blau, C Anthony, Detraux, Damien, Devi, Arikketh, Ericson, Nolan G, Ferreccio, Amy, Fiehn, Oliver, Fischer, Karin A, Gu, Haiwei, Hawkins, R David, Hesson, Jennifer, Hockenbery, David, Margaretha, Lilyana, Margineantu, Daciana, Margolin, Adam A, Mathieu, Julie, Moon, Randall T, Raftery, Daniel, Robitaille, Aaron M, Ruohola-Baker, Hannele, Showalter, Megan, Sperber, Henrik, Valensisi, Cristina, Wang, Yuliang, Ware, Carol B, Xu, Zhuojin   +26 more
core  

Droplet Barcoding for Single-Cell Transcriptomics Applied to Embryonic Stem Cells

Cell, 2015
Allon M. Klein, L. Mazutis, Ilke Akartuna, Naren P. Tallapragada, A. Veres, V. Li, L. Peshkin, D. Weitz, M. Kirschner   +8 more
semanticscholar   +1 more source

Targeting Decidual CD16+ Immune Cells with Exosome‐Based Glucocorticoid Nanoparticles for Miscarriage

Advanced Science, EarlyView.
Exosome‐based nanoparticles (GC‐Exo‐CD16Ab) are designed to deliver glucocorticoids (GC) specifically to decidual CD16+ NK cells and macrophages. This targeted delivery effectively suppresses the cytotoxicity of decidual NK cells, inhibits M1 macrophage polarization, and modulates the decidual microenvironment.
Linlin Wang, Zhinang Yin, Yanqiong Shen, Gang Feng, Fangfang Dai, Dongyong Yang, Zhimin Deng, Jing Yang, Ruizhi Chen, Leifeng Yang, Xian Chen, Qing Sun, Chunyu Huang, Yanxiang Cheng, Hongbing Deng, Lianghui Diao, Longfei Li, Tailang Yin   +17 more
wiley   +1 more source

Sel Kumulus Sebagai Feeder Layer pada Kultur Stem Cells Embrionic Mencit (CUMULUS CELLS AS FEEDER LAYER IN CULTURE OF MOUSE EMBRYONIC STEM CELLS)

Jurnal Veteriner, 2014
The purpose of this study was to verify the effectiveness of cumulus cells as a feeder layer in supportingthe growth of mouse embryonic stem cells. Embryos at blastocyst stage were exposed in pronase solution,and then incubated in rabbit anti-mouse ...
Thomas Mata Hine, Arief Boediono, Iman Supriatna, Dondin Sajuthi   +3 more
doaj  

UFMylation of NLRP3 Prevents Its Autophagic Degradation and Facilitates Inflammasome Activation

Advanced Science, EarlyView.
This article studies the role of UFMylation in NLRP3 inflammasome activation. It reveals that UFMylation, mediated by the E3 Ufm1‐ligase 1 (Ufl1), maintains NLRP3 stability by preventing its ubiquitination and subsequent autophagic degradation.
Jiongjie Jing, Fan Yang, Ke Wang, Mintian Cui, Ni Kong, Shixi Wang, Xiaoyue Qiao, Fanyu Kong, Dongyang Zhao, Jinlu Ji, Lunxian Tang, Jiaxin Gao, Yu‐Sheng Cong, Deqiang Ding, Kun Chen   +14 more
wiley   +1 more source