The emerin-binding transcription factor Lmo7 is regulated by association with p130Cas at focal adhesions [PDF]
PeerJ, 2013 Loss of function mutations in the nuclear inner membrane protein, emerin, cause X-linked Emery-Dreifuss muscular dystrophy (X-EDMD). X-EDMD is characterized by contractures of major tendons, skeletal muscle weakening and wasting, and cardiac conduction ...
Michele A. Wozniak +3 more
doaj +2 more sources
Concise Review: Plasma and Nuclear Membranes Convey Mechanical Information to Regulate Mesenchymal Stem Cell Lineage [PDF]
, 2016 Numerous factors including chemical, hormonal, spatial, and physical cues determine stem cell fate. While the regulation of stem cell differentiation by soluble factors is well-characterized, the role of mechanical force in the determination of lineage ...
Fuchs, Robyn K. +3 more
core +1 more source
Barrier-to-autointegration factor (BAF) involvement in prelamin a-related chromatin organization changes [PDF]
, 2015 Chromatin disorganization is one of the major alterations linked to prelamin A processing impairment. In this study we demonstrate that BAF is necessary to modulate prelamin A effects on chromatin structure.
Capanni, Cristina +7 more
core +3 more sources
iMeta, Volume 4, Issue 6, December 2025.This study identifies the uncharacterized gene C9ORF50 as a novel regulator of immune evasion. Functioning as an intrinsically disordered protein, C9ORF50 drives liquid‐liquid phase separation to facilitate spliceosome assembly and maintain RNA splicing fidelity.
Tong Shao +24 more
wiley +1 more source
Chromosome structure: improved immunolabeling for electron microscopy [PDF]
, 2018 To structurally dissect mitotic chromosomes, we aim to position along the folded chromatin fiber proteins involved in long-range order, such as topoisomerase IIα (topoIIα) and condensin.
Eltsov, Michail +2 more
core
Identification of tyrosine‐phosphorylation sites in the nuclear membrane protein emerin [PDF]
The FEBS Journal, 2006 Although several proteins undergo tyrosine phosphorylation at the nuclear envelope, we achieved, for the first time, the identification of tyrosine‐phosphorylation sites of a nuclear‐membrane protein, emerin, by applying two mass spectrometry‐based techniques.
Andreas, Schlosser +2 more
openaire +2 more sources
Image analysis of the nuclear characteristics of emerin protein and the correlation with nuclear grooves and intranuclear cytoplasmic inclusions in lung adenocarcinoma [PDF]
, 2019 学位記番号 ...
Kobayashi, Sayaka +2 more
core
Mechanical Signaling: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets
MedComm, Volume 6, Issue 12, December 2025.In this review, we summarize cell–ECM interactions and delve into the complex mechanotransduction. We introduce advanced research methods and emerging clinical tools used to study cellular mechanical phenotypes, mechanotransduction, and disease progression. Additionally, we analyze the role of mechanical biomarkers in the development and progression of
Yicen Long +5 more
wiley +1 more source
Familial Dilated Cardiomyopathy and Isolated Left Ventricular Noncompaction Associated With Lamin A/C Gene Mutations [PDF]
, 2004 [Abstract] LMNA mutations have been associated with familial or sporadic dilated cardiomyopathy (DC), with or without conduction system disease. We studied the LMNA gene in 67 consecutive patients with DC (18 had familial DC, 17 had possible familial DC,
Bouzas-Zubeldia, Beatriz +10 more
core +2 more sources
The Inner Nuclear Membrane Has a Unique Lipid Signature
BioEssays, Volume 47, Issue 10, October 2025.The inner nuclear membrane (INM) has a distinct lipid profile, most notably characterized by high enrichment of phosphatidylserine (PS). In this review, Yang Niu and Tamas Balla summarize recent advances in elucidating the INM's lipid composition and related metabolic pathways, while elaborating further on their potential functional roles.
Yang Niu, Tamas Balla
wiley +1 more source