Results 101 to 110 of about 6,268 (192)

Emerin oligomerisation properties, impact on lamin and actin recognition [PDF]

Orphanet Journal of Rare Diseases, 2015
Since a few years, several studies have revealed the essential role played by the nuclear envelope in the cell response to mechanical demands of their immediate surroundings. A systematic scaling between the concentration of lamins within the nucleoskeleton and tissue elasticity was observed. This tuning in the nuclear lamina composition was associated
Herrada, Isaline, Zinn-Justin, Sophie
openaire   +1 more source

cTAGE5/MEA6 Regulates LBR Localization to Maintain Nuclear Envelope Integrity and Safeguard Against Aging

Aging Cell, Volume 24, Issue 10, October 2025.
cTAGE5 regulates LBR trafficking between the ER and the nucleus membrane to maintain the integrity of both the ER and the nuclear envelope. cTAGE5 KO results in LBR retention in the ER, reduced stability, and subsequent disruption of nuclear envelope integrity. ABSTRACT cTAGE5/MEA6 plays a pivotal role in COPII complex assembly, ER‐to‐Golgi trafficking,
Yaqing Wang, Pengyu Sun, Fuqiang Yang, Tiantian Ma, Junwan Fan, Lei Shi, Nan Li, Fei Gao, Kangmin He, Zhiheng Xu   +9 more
wiley   +1 more source

Inter- and intra-specific gene-density-correlated radial chromosome territory arrangements are conserved in Old World monkeys [PDF]

, 2005
Recently it has been shown that the gene-density correlated radial distribution of human 18 and 19 homologous chromosome territories (CTs) is conserved in higher primates in spite of chromosomal rearrangements that occurred during evolution.
ISHIDA Takafumi, KüPPER Katrin, MIZUSAWA Hiroshi, NEUSSER Michaela, TANABE Hideyuki, 秀之 田辺　   +5 more
core   +1 more source

Apolipoprotein M (ApoM) Ameliorates Acute Alcohol Intoxication (AAI)‐Hemorrhagic Shock and Resuscitation (HSR)‐Induced Microvascular Leakage

Microcirculation, Volume 32, Issue 7, October 2025.
ABSTRACT Objective Microvascular hyperpermeability is a serious complication that occurs from hemorrhagic shock and resuscitation (HSR), especially when combined with acute alcohol intoxication (AAI). We tested the hypothesis that administration of Apolipoprotein M (ApoM), a lipocalin that normally resides in plasma high‐density lipoproteins (HDL) and ...
Mengmeng Chang, Jerome W. Breslin
wiley   +1 more source

Role of the nuclear membrane protein Emerin in front-rear polarity of the nucleus

Nature Communications, 2020
During cell migration, cells are polarized with distinct front vs. rear regions but whether and how polarity is transmitted to the nucleus is unclear.
Paulina Nastały, Divya Purushothaman, Stefano Marchesi, Alessandro Poli, Tobias Lendenmann, Gururaj Rao Kidiyoor, Galina V. Beznoussenko, Stefania Lavore, Orso Maria Romano, Dimos Poulikakos, Marco Cosentino Lagomarsino, Alexander A. Mironov, Aldo Ferrari, Paolo Maiuri   +13 more
doaj   +1 more source

The Extremely Low Mechanical Force Generated by Nano‐Pulling Induces Global Changes in the Microtubule Network, Nuclear Morphology, and Chromatin Transcription in Neurons

Small, Volume 21, Issue 38, September 25, 2025.
Nano‐pulling induces stabilization, reorganization, and reorientation of the microtubule network. The nucleus of stretched cells experiences increased lateral tension, becomes more spherical, and develops surface grooves. At the level of gene expression regulation, changes in nuclear morphology induce global chromatin remodeling, leading to reduced ...
Alessandro Falconieri, Lorenzo Da Palmata, Valentina Cappello, Tiziana Julia Nadjeschda Schmidt, Pietro Folino, Barbara Storti, Ranieri Bizzarri, Vittoria Raffa   +7 more
wiley   +1 more source

The nucleoporin Nup205/NPP-3 is lost near centrosomes at mitotic onset and can modulate the timing of this process in Caenorhabditis elegans embryos [PDF]

, 2012
This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License ...
Askjaer, Peter, Busso, Coralie, Gönczy, Pierre, Hachet, Virginie, Sugimoto, Asako, Toya, Mika   +5 more
core   +1 more source

Extracellular Vesicle Protein Panel Enables Early Lung Cancer Detection in a Large Clinical Cohort

Journal of Extracellular Vesicles, Volume 14, Issue 8, August 2025.
ABSTRACT The early detection and diagnosis of lung cancer through extracellular vesicle (EV)‐based liquid biopsy show substantial promise for enhancing clinical outcomes. Nonetheless, there is a scarcity of large‐scale clinical investigations validating EV‐based liquid biopsy.
Linxiao Han, Yuanlin Song, Lin Tong, Jiayuan Sun, Xiaoju Zhang, Shujing Chen, Ying Li, Ziqi Wang, Lei Gao, Qiaoliang Zhu, Yencheng Chao, Xiaocen Wang, Ge Zhang, Wensi Zhu, Ludan He, Jie Liu, Qin Wang, Zuoren Wu, Yuanyuan Ji, Chunxue Bai, Xiuzhen Lv, Jian Zhou   +21 more
wiley   +1 more source

Emerin and the Nuclear Lamina in Muscle and Cardiac Disease [PDF]

Circulation Research, 2008
The human genome is contained within the nucleus and is separated from the cytoplasm by the nuclear envelope. Mutations in the nuclear envelope proteins emerin and lamin A cause a number of diseases including premature aging syndromes, muscular dystrophy, and cardiomyopathy.
openaire   +2 more sources

Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress

eLife, 2019
The inner nuclear membrane (INM) is a subdomain of the endoplasmic reticulum (ER) that is gated by the nuclear pore complex. It is unknown whether proteins of the INM and ER are degraded through shared or distinct pathways in mammalian cells.
Abigail Buchwalter, Roberta Schulte, Hsiao Tsai, Juliana Capitanio, Martin Hetzer   +4 more
doaj   +1 more source