Results 111 to 120 of about 6,268 (192)
Specific nuclear envelope transmembrane proteins can promote the location of chromosomes to and from the nuclear periphery [PDF]
, 2013 BACKGROUND: Different cell types have distinctive patterns of chromosome positioning in the nucleus. Although ectopic affinity-tethering of specific loci can be used to relocate chromosomes to the nuclear periphery, endogenous nuclear envelope proteins ...
David A Kelly +12 more
core +3 more sources
Developmental changes in nuclear lamina components during germ cell differentiation
NucleusThe nuclear lamina (NL) changes composition for regulation of nuclear events. We investigated changes that occur in Drosophila oogenesis, revealing switches in NL composition during germ cell differentiation.
Isabella E. Perales +3 more
doaj +1 more source
Ancient eukaryotic origin and evolutionary plasticity of nuclear lamina [PDF]
, 2016 The emergence of the nucleus was a major event of eukaryogenesis. How the nuclear envelope (NE) arose and acquired functions governing chromatin organization and epigenetic control has direct bearing on origins of developmental/stage-specific expression ...
Field, Mark C., Koreny, Ludek
core +2 more sources
Nuclear envelope proteins and chromatin arrangement: a pathogenic mechanism for laminopathies
European Journal of Histochemistry, 2009 The involvement of the nuclear envelope in the modulation of chromatin organization is strongly suggested by the increasing number of human diseases due to mutations of nuclear envelope proteins.
NM Maraldi +6 more
doaj +1 more source
Characterization of the DNA binding property of emerin
Proceedings of the Japan Academy, Series B, 2001 Emerin is an inner nuclear membrane protein, which is the gene product responsible for X-linked Emery-Dreifuss muscular dystrophy (X-EDMD). In this study we extracted emerin from mammalian cells and examined the DNA binding property by in vitro binding assay with double-strand DNA cellulose.
Asako HASE, Kiichi ARAHATA
openaire +2 more sources
IMPACT OF BETA‐DYSTROGLYCAN DEFICIENCY ON EMERIN FUNCTIONS
The FASEB Journal, 2018 Beta‐dystroglycan (b‐DG) is a plasma membrane protein that belongs to the dystrophin‐associated protein complex (DAPC), the latter provides a link between the extracellular matrix and the cytoskeleton. Previously we reported that b‐DG is translocated localized to the nucleus via recognition of its nuclear localization signal (NLS), located in the ...
Jesús Mauricio Ernesto Hernández Méndez +5 more
openaire +1 more source
Serum cystatin C and chemerin levels in diabetic retinopathy [PDF]
, 2017 Peer reviewedPublisher ...
Chen, Xuedong +5 more
core
Stem Cell Research, 2017 The ability of iPSCs (induced pluripotent stem cells) to generate any cell type in the body makes them valuable tools for cell replacement therapies. However, differentiation of iPSCs can be demanding, slow and variable.
Cecilia Bergqvist +4 more
doaj +1 more source
An Intronic Heterozygous SYNE2 Splice Site Mutation: A Rare Cause for Myalgia and hyperCKemia?
MusclesSYNE2 mutations have been associated with skeletal and cardiac muscle diseases, including Emery-Dreifuss muscular dystrophy (EDMD). Here, we present a 70-year-old male patient with muscle pain and elevated serum creatine kinase levels in whom whole-exome
Theresa Paulus +10 more
doaj +1 more source
Distrofia muscular de Emery-Dreifuss: a propósito de um caso clínico
Revista Portuguesa de Cardiologia, 2012 Resumo: A distrofia muscular de Emery Dreifuss tipo 1 (DMED1) é uma doença familiar, com transmissão recessiva ligada ao X, resultante da mutação de uma proteína do invólucro nuclear, a emerina.
Fátima Saraiva +6 more
doaj +1 more source