Results 131 to 140 of about 3,144 (163)

Emerin presence in platelets

Acta Neuropathologica, 2000
Emerin is an almost ubiquitous protein which is abnormal in X-linked Emery-Dreifuss muscular dystrophy (EMD), a syndrome characterized by muscle weakness, joint contractures and cardiac arrhythmia. Emerin is localized in the cells at the nuclear rim and its function is still unknown.
Stefano Squarzoni, Daniela Toniolo, Luciano Merlini   +2 more
exaly   +3 more sources

Emerin and the Nuclear Lamina in Muscle and Cardiac Disease [PDF]

Circulation Research, 2008
The human genome is contained within the nucleus and is separated from the cytoplasm by the nuclear envelope. Mutations in the nuclear envelope proteins emerin and lamin A cause a number of diseases including premature aging syndromes, muscular dystrophy, and cardiomyopathy.
James Holaska
exaly   +3 more sources

The Molecular Basis and Biologic Significance of the β-Dystroglycan-Emerin Interaction [PDF]

International Journal of Molecular Sciences, 2020
β-dystroglycan (β-DG) assembles with lamins A/C and B1 and emerin at the nuclear envelope (NE) to maintain proper nuclear architecture and function. To provide insight into the nuclear function of β-DG, we characterized the interaction between β-DG and emerin at the molecular level. Emerin is a major NE protein that regulates multiple nuclear processes
Ricardo Mondragón-González, Jesus Mauricio Ernesto Hernández Méndez, Jhon Erick Rivera   +2 more
exaly   +10 more sources

The molecular basis of emerin-emerin and emerin-BAF interactions.

Journal of cell science, 2015
Emerin is a conserved membrane component of nuclear lamina structure. Here, we report an advance in understanding the molecular basis of emerin function: intermolecular emerin-emerin association. There were two modes: one mediated by association of residues 170-220 in one emerin molecule to residues 170-220 in another, and the second involving residues
Jason M, Berk, Dan N, Simon, Clifton R, Jenkins-Houk, Jason W, Westerbeck, Line M, Grønning-Wang, Cathrine R, Carlson, Katherine L, Wilson   +6 more
openaire   +2 more sources

Emerin expression in early development of Xenopus laevis

European Journal of Cell Biology, 2005
Emerin is an integral protein of the inner nuclear membrane in the majority of differentiated vertebrate cells. In humans, deficiency of emerin causes a progressive muscular dystrophy of the Emery-Dreifuss type. The physiological role of emerin is poorly understood.
Marie-Christine Dabauvalle, Hanswalter Zentgraf   +1 more
exaly   +3 more sources

Two distal mutations in the gene encoding emerin have profoundly different effects on emerin protein expression

Neuromuscular Disorders, 2000
Emerin, the product of the gene responsible for X-linked Emery-Dreifuss muscular dystrophy (EDMD), has a ubiquitous tissue distribution and is localised to the nuclear envelope. We present here the relationship between emerin protein expression, nuclear localization and clinical phenotype for two distal mutations identified in unrelated EDMD patients ...
John R W Yates, Juliet A Ellis, J R Yates   +2 more
exaly   +4 more sources

Direct Interaction between Emerin and Lamin A

Biochemical and Biophysical Research Communications, 2000
Emerin is the protein of the inner nuclear membrane that is affected by mutation in X-linked Emery-Dreifuss muscular dystrophy. The autosomal dominant form of the disease is caused by mutations in the lamin A/C gene. Several lines of circumstantial evidence have suggested an interaction of emerin with lamins in the nuclear lamina but direct interaction
L, Clements, S, Manilal, D R, Love, G E, Morris   +3 more
openaire   +2 more sources

Interaction between Emerin and Nuclear Lamins

Journal of Biochemistry, 2001
Emerin is an inner nuclear membrane protein that is involved in X-linked recessive Emery-Dreifuss muscular dystrophy (X-EDMD). Although the function of this protein is still unknown, we revealed that C-terminus transmembrane domain-truncated emerin (amino acid 1-225) binds to lamin A with higher affinity than lamin C.
M, Sakaki, H, Koike, N, Takahashi, N, Sasagawa, S, Tomioka, K, Arahata, S, Ishiura   +6 more
openaire   +2 more sources

Emerin

The International Journal of Biochemistry & Cell Biology, 1999
Emerin encoded by the STA gene is the first nuclear protein linked with a muscular dystrophy. Emerin is a 34 kDa, predominantly hydrophilic protein with a single hydrophobic region supposed to serve as a transmembrane domain. It was classified as a type II integral membrane protein localized at the inner nuclear membrane/nuclear lamina with an ...
openaire   +2 more sources

Role of structural flexibility in the evolution of emerin

Journal of Theoretical Biology, 2015
Emerin is a short inner nuclear membrane protein with an LEM-domain at the N-terminal end and a transmembrane domain at the C-terminal end. The middle region of human emerin contains multiple binding motifs. Since emerin is often found in evolutionarily newer species, the functional conservation of emerin becomes an interesting topic. In this study, we
Jia, Yuan, Bin, Xue
openaire   +2 more sources