Results 31 to 40 of about 6,268 (192)
Emerin intermolecular links to emerin and BAF
Journal of Cell Science, 2014 Emerin is a conserved nuclear membrane LEM-domain protein that binds lamins and BAF (barrier-to-integration factor; BANF1) as a component of nuclear lamina structure. We report an advance in understanding the molecular basis of emerin function: inter-molecular emerin-emerin association.
Jason M. Berk +6 more
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PLoS Biology, 2004 X-linked Emery-Dreifuss muscular dystrophy is caused by loss of emerin, a LEM-domain protein of the nuclear inner membrane. To better understand emerin function, we used affinity chromatography to purify emerin-binding proteins from nuclear extracts of ...
James M Holaska +2 more
doaj +1 more source
Emerin anchors Msx1 and its protein partners at the nuclear periphery to inhibit myogenesis
Cell & Bioscience, 2019 Background Previous studies have shown that in myogenic precursors, the homeoprotein Msx1 and its protein partners, histone methyltransferases and repressive histone marks, tend to be enriched on target myogenic regulatory genes at the nuclear periphery.
Zhangjing Ma +8 more
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Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS [PDF]
, 2018 Defects in stress response are main determinants of cellular senescence and organism aging. In fibroblasts from patients affected by Hutchinson-Gilford progeria, a severe LMNA-linked syndrome associated with bone resorption, cardiovascular disorders, and
Andrenacci, Davide +13 more
core +2 more sources
Disease Models & Mechanisms, 2017 Mutations in the gene encoding emerin cause Emery–Dreifuss muscular dystrophy (EDMD). Emerin is an integral inner nuclear membrane protein and a component of the nuclear lamina. EDMD is characterized by skeletal muscle wasting, cardiac conduction defects
Carol M. Collins +2 more
doaj +1 more source
Emerin expression in tubular aggregates
Acta Neuropathologica, 2004 Emerin is an inner nuclear membrane protein that is mutated or not expressed in patients with X-linked Emery-Dreifuss muscular dystrophy (X-EDMD/EMD). Cytoplasmic localization of emerin in cultured cells or tissues has been reported, although this remains a controversial issue. Tubular aggregates (TAs) are pathological structures seen in the sarcoplasm
Manta, P. +4 more
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Emerin Represses STAT3 Signaling through Nuclear Membrane-Based Spatial Control [PDF]
International Journal of Molecular Sciences, 2021 Emerin is the inner nuclear membrane protein involved in maintaining the mechanical integrity of the nuclear membrane. Mutations in EMD encoding emerin cause Emery–Dreifuss muscular dystrophy (EDMD). Evidence is accumulating that emerin regulation of specific gene expression is associated with this disease, but the exact function of emerin has not been
Byongsun Lee +4 more
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Nuclear Envelope, Nuclear Lamina, and Inherited Disease [PDF]
, 2005 The nuclear envelope is composed of the nuclear membranes, nuclear lamina, and nuclear pore complexes. In recent years, mutations in nuclear-envelope proteins have been shown to cause a surprisingly wide array of inherited diseases.
Courvalin, Jean-Claude, Worman, Howard,
core +4 more sources
Emerin Deletions Occurring on Both Xq28 Inversion Backgrounds [PDF]
Human Molecular Genetics, 1998 Emery-Dreifuss muscular dystrophy (EMD) is an X-linked disorder characterized by contractures, progressive weakness and cardiomyopathy. EMD is caused by mutations in the 2 kb emerin gene that is located within human Xq28. Emerin is immediately distal to the 26 kb filamin gene, and flanking the filamin-emerin region are two large inverted repeats.
K, Small, S T, Warren
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The effects of swimming training on N-cadherin, β-catenin and Emerin in cardiac left ventricle of male Wistar rat [PDF]
مجله پزشکی دانشگاه علوم پزشکی تبریز, 2020 Background: Physical activity and exercise training plays a protective role against cardiovascular disease via reducing risk factors. Swimming as one of the best aerobic activity and exercise modality recommended for preventing and treatment of ...
Masoumeh Asadi +2 more
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